公开(公告)号：WO2007081521A3

公开(公告)日：2008-02-14

申请号：PCT/US2006048711

申请日：2006-12-20

Applicant: ESSENTIALIS INC ,  COWEN NEIL M ,  KASHKIN KENNETH B ,  YAMOUT KHALED A

Inventor： COWEN NEIL M ,  KASHKIN KENNETH B ,  YAMOUT KHALED A

IPC: A61K31/54

CPC classification number: A61K31/549 ,  A61K9/2086 ,  A61K31/54 ,  A61K38/27 ,  A61K45/06 ,  C07C209/68 ,  C07C213/08 ,  C07D285/24

Abstract: Provided are immediate or prolonged administration of certain salts of K ATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving K ATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

Abstract translation: 提供对受试者立即或长期施用某些K ATP通道开放剂如二氮嗪的盐，以在治疗涉及的疾病或病症中获得新颖的药效学，药代动力学，治疗学，生理学，代谢和组合结果 ATP通道。 还提供了实现这些结果的药物制剂，施用方法和给药盐，并减少治疗个体的不良反应的发生率。 进一步提供了与其它药物共同施用盐以治疗人和动物疾病的方法。

公开(公告)号：WO2006026469A3

公开(公告)日：2006-03-09

申请号：PCT/US2005/030481

申请日：2005-08-25

Applicant: ESSENTIALIS, INC. ,  COWEN, Neil, M. ,  KASHKIN, Kenneth, B.

Inventor： COWEN, Neil, M. ,  KASHKIN, Kenneth, B.

IPC: A61K9/52 ,  A61K9/22

Abstract: Provided are immediate or prolonged administration of certain potassium ATP (K ATP ) channel openers to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving K ATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of K ATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering K AT P channel openers with other drugs to treat diseases of humans and animals.

公开(公告)号：WO2009006483A1

公开(公告)日：2009-01-08

申请号：PCT/US2008/068936

申请日：2008-07-01

Applicant: ESSENTIALIS, INC. ,  COWEN, Neil, M. ,  DUKES, Lain

Inventor： COWEN, Neil, M. ,  DUKES, Lain

IPC: A61K31/54

CPC classification number: A61K31/54

Abstract: Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

Abstract translation: 提供对受试者立即或长期给予KATP通道开放剂如二氮嗪的某些盐，以在治疗涉及KATP通道的疾病或病症中获得新颖的药效学，药代动力学，治疗学，生理学，代谢和组合结果。 还提供了实现这些结果的药物制剂，施用方法和给药盐，并减少治疗个体的不良反应的发生率。 进一步提供了与其它药物共同施用盐以治疗人和动物疾病的方法。

公开(公告)号：WO2006026469A2

公开(公告)日：2006-03-09

申请号：PCT/US2005030481

申请日：2005-08-25

Applicant: ESSENTIALIS INC ,  COWEN NEIL M ,  KASHKIN KENNETH B

Inventor： COWEN NEIL M ,  KASHKIN KENNETH B

IPC: A61K9/22 ,  A61K31/655

CPC classification number: A61K31/549 ,  A61K9/0004 ,  A61K9/2054 ,  A61K9/2853 ,  A61K9/5026 ,  A61K9/5047 ,  A61K31/655

Abstract: Provided are immediate or prolonged administration of certain potassium ATP (K ATP ) channel openers to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving K ATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of K ATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering K AT P channel openers with other drugs to treat diseases of humans and animals.

Abstract translation: 提供给受试者立即或延长施用某些钾ATP（ATP）通道开放剂以实现治疗涉及K的疾病或病症的新的药效学，药代动力学，治疗，生理，代谢和组成结果 _{ATP 频道。 还提供了实现这些结果并降低受治疗个体不良反应发生率的药物制剂，给药和给药K ATP 通道开放剂的方法。 进一步提供了与其他药物共同施用K SUB开放剂以治疗人类和动物疾病的方法。}

公开(公告)号：WO2007081521A2

公开(公告)日：2007-07-19

申请号：PCT/US2006/048711

申请日：2006-12-20

Applicant: ESSENTIALIS, INC. ,  COWEN, Neil, M. ,  KASHKIN, Kenneth, B. ,  YAMOUT, Khaled, A.

Inventor： COWEN, Neil, M. ,  KASHKIN, Kenneth, B. ,  YAMOUT, Khaled, A.

IPC: A61K31/549

CPC classification number: A61K31/549 ,  A61K9/2086 ,  A61K31/54 ,  A61K38/27 ,  A61K45/06 ,  C07C209/68 ,  C07C213/08 ,  C07D285/24

Abstract: Provided are immediate or prolonged administration of certain salts of K ATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving K ATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

Abstract translation: 提供对受试者立即或长期施用某些K ATP通道开放剂如二氮嗪的盐，以在治疗涉及的疾病或病症中获得新颖的药效学，药代动力学，治疗学，生理学，代谢和组合结果 ATP通道。 还提供了实现这些结果的药物制剂，施用方法和给药盐，并减少治疗个体的不良反应的发生率。 进一步提供了与其它药物共同施用盐以治疗人和动物疾病的方法。

公开(公告)号：WO9916300B1

公开(公告)日：1999-05-14

申请号：PCT/US9820722

申请日：1998-10-01

Applicant: DOW AGROSCIENCES LLC ,  THOMPSON STEVEN A ,  COWEN NEIL M

Inventor： THOMPSON STEVEN A ,  COWEN NEIL M

IPC: A01H5/10 ,  A01H5/00 ,  A01H1/00 ,  A01H4/00 ,  C12N5/04

CPC classification number: A01H5/10

Abstract: Inbred maize lines designated as 4SQ601 and 4SQ602, plants and seeds of such maize lines, methods for producing maize plants by crossing said lines with themselves or another maize plant, and hybrid maize seeds and plants produced by crossing said inbred maize lines with another maize line or plant. Marker-assisted selection of maize plants wherein the genetic markers are associated with high kernel oil content, and high oil maize plants having novel combinations of genetic markers associated with high kernel oil content, and plant parts and uses thereof.

Abstract translation: 称为4SQ601和4SQ602的近交玉米系，这种玉米系的植物和种子，通过使所述系与它们自己或另一个玉米植物杂交而产生玉米植物的方法，以及通过将所述近交系玉米系与另一玉米系杂交而产生的杂交玉米种子和植物 或植物。 其中遗传标记与高核仁油含量相关的玉米植物的标记辅助选择，以及具有与高核仁油含量相关的遗传标记的新组合的高油玉米植物，以及植物部分和其用途。