公开(公告)号：WO2020254403A1

公开(公告)日：2020-12-24

申请号：PCT/EP2020/066761

申请日：2020-06-17

Applicant: EVONIK OPERATIONS GMBH

Inventor： WEFER, Johannes ,  HASSELBACH, Hans-Joachim ,  WINKLER, Tobias ,  DE CORTE, Danny ,  DRAPAL, Bernd ,  MOUSSALLEM, Imad ,  RENNER, Christian ,  RÜCKRIEGEL, Christian

IPC: C07C319/20 ,  C07C319/28 ,  C07C323/58

Abstract: The invention relates to a single cycle process for preparing D,L-methionine from an alkali methioninate solution obtained by alkaline hydrolysis of 5-(2-methylmercaptoethyl)hydantoin, in which the D,L-methionine is obtained by neutralizing the alkali methioninate solution with carbon dioxide at elevated temperature and subsequently crystallizing D,L-methionine in the presence of seed crystals.

公开(公告)号：WO2020200952A1

公开(公告)日：2020-10-08

申请号：PCT/EP2020/058340

申请日：2020-03-25

Applicant: EVONIK OPERATIONS GMBH

Inventor： STAHL, Timo ,  RONNEBURG, Axel ,  MOUSSALLEM, Imad ,  HALLI, Juliette ,  PICHA, Petra

IPC: C07C51/08 ,  C07C253/16 ,  C07D301/12 ,  C12P7/42 ,  C07C59/01 ,  C07C255/11

Abstract: The present invention pertains to a process for preparing 3-hydroxy-3-methylbutyrate (HMB) or a salt thereof, the method comprising (a) reacting isobutylene oxide with cyanide in order to obtain 3- hydroxy-3-methylbutyronitrile, and (b) hydrolyzing the 3-hydroxy-3-methylbutyronitrile obtained in step (a) in order to obtain HMB, wherein hydrolysis step (b) is performed using either at least one nitrilase enzyme or, alternatively, using a combination of enzymes, said combination comprising at least one nitrile hydratase and at least one amidase.

公开(公告)号：WO2020120720A1

公开(公告)日：2020-06-18

申请号：PCT/EP2019/085005

申请日：2019-12-13

Applicant: EVONIK OPERATIONS GMBH

Inventor： SUDHOFF, Daniel ,  HIEROLD, Judith ,  ROTH, Philipp ,  MOUSSALLEM, Imad ,  BINDERNAGEL, Ulf ,  RENNER, Christian

IPC: C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07D233/76

Abstract: The present invention pertains to a method for producing methionine or salts or derivatives thereof from hydrogen cyanide (HCN), the method comprising a step of producing 2-hydroxy-4-(methylthio)butyronitrile (MMP-CN), or a crude product mixture comprising MMP-CN, by contacting a hydrogen cyanide (HCN) process gas mixture prepared according to the Andrussow process from methane, ammonia and oxygen, with 3-methylmercaptopropionaldehyde (MMP), wherein the HCN process gas mixture is obtained from the crude HCN process gas mixture by adjusting the amount of ammonia to between 20 % (v/v) and 60% (v/v) of the amount of the ammonia in the crude HCN process gas mixture.