公开(公告)号：WO2022048913A1

公开(公告)日：2022-03-10

申请号：PCT/EP2021/073004

申请日：2021-08-19

Applicant: EVONIK OPERATIONS GMBH

Inventor： STAHL, Timo ,  RONNEBURG, Axel ,  JÄGER, Barbara ,  ROTH, Philipp

IPC: C07C227/02 ,  C07C279/14 ,  C07C279/28 ,  C07C277/00

Abstract: The present invention refers to a method for preparing guanidino acetic acid by reacting cyanamide and glycine in an aqueous reaction mixture in the presence of a base, wherein the ammonia content in the reaction mixture is controlled to be below 20 g/L and wherein the dicyandiamide content in the reaction mixture is kept below 5 wt.-%.

公开(公告)号：WO2022048909A1

公开(公告)日：2022-03-10

申请号：PCT/EP2021/072929

申请日：2021-08-18

Applicant: EVONIK OPERATIONS GMBH

Inventor： STAHL, Timo ,  RONNEBURG, Axel ,  ROTH, Philipp

IPC: C07C227/02 ,  C07C279/14 ,  C07C277/00

Abstract: The present invention concerns a modified method for preparing guanidine acetic acid (GAA) by reacting cyanamide with an excess molar amount of glycine in an aqueous reaction mixture in the presence of a base that avoids high molar amounts of base or acid for pH control under maintaining the reaction selectivity and product yields.

公开(公告)号：WO2022028821A1

公开(公告)日：2022-02-10

申请号：PCT/EP2021/069423

申请日：2021-07-13

Applicant: EVONIK OPERATIONS GMBH

Inventor： STAHL, Timo ,  STENNER, Patrik ,  RONNEBURG, Axel ,  TEICHMANN, Julian

IPC: C25B3/03 ,  C25B3/07 ,  C25B3/00 ,  C07C51/145 ,  C07C59/01

Abstract: The present invention pertains to a method for preparing 3-hydroxy-3-methylbutyric acid (HMB) or salts thereof from tert-butanol and carbon monoxide, wherein tert-butanol is reacted in an aqueous mixture with carbon monoxide under electrolytic conditions.

公开(公告)号：WO2020200952A1

公开(公告)日：2020-10-08

申请号：PCT/EP2020/058340

申请日：2020-03-25

Applicant: EVONIK OPERATIONS GMBH

Inventor： STAHL, Timo ,  RONNEBURG, Axel ,  MOUSSALLEM, Imad ,  HALLI, Juliette ,  PICHA, Petra

IPC: C07C51/08 ,  C07C253/16 ,  C07D301/12 ,  C12P7/42 ,  C07C59/01 ,  C07C255/11

Abstract: The present invention pertains to a process for preparing 3-hydroxy-3-methylbutyrate (HMB) or a salt thereof, the method comprising (a) reacting isobutylene oxide with cyanide in order to obtain 3- hydroxy-3-methylbutyronitrile, and (b) hydrolyzing the 3-hydroxy-3-methylbutyronitrile obtained in step (a) in order to obtain HMB, wherein hydrolysis step (b) is performed using either at least one nitrilase enzyme or, alternatively, using a combination of enzymes, said combination comprising at least one nitrile hydratase and at least one amidase.