公开(公告)号：WO2017109696A1

公开(公告)日：2017-06-29

申请号：PCT/IB2016/057824

申请日：2016-12-20

Applicant: FIDIA FARMACEUTICI S.P.A. ,  NANOGETIC S.L.

Inventor： SANCHEZ MARTIN, Rosario Maria ,  PERNAGALLO, Salvatore ,  UNCITI BROCETA, Juan Diego ,  MESSINA, Luciano ,  VACCARO, Susanna ,  PILOTTO, Laura

IPC: A61K47/69

CPC classification number: A61K47/6933

Abstract: Disclosed is a nanoparticle system consisting of a polymer support or substrate in the form of nanoparticles to which a hydrolase enzyme able to degrade hyaluronic acid and one or more biologically and/or pharmacologically active molecules are covalently bonded, its preparation process and its uses in the diagnostic, prognostic and therapeutic fields.

Abstract translation:

本发明公开了在哪个水解酶能够降解透明质酸和一种或多种生物和/或药理学活性分子共价键合的纳米颗粒的形式构成的聚合物支撑或衬底的纳米颗粒系统， 其制备过程及其在诊断，预后和治疗领域的应用。

公开(公告)号：WO2014203133A1

公开(公告)日：2014-12-24

申请号：PCT/IB2014/062193

申请日：2014-06-13

Applicant: FIDIA FARMACEUTICI S.P.A.

Inventor： MESSINA, Luciano ,  MUSUMECI, Luca ,  VACCARO, Susanna

IPC: C07K14/315 ,  C12N9/26

CPC classification number: C12N9/2474 ,  A61K38/00 ,  C12Y302/01035

Abstract: The present invention relates to a hyaluronidase from S. koganeiensis , applications thereof and a method for the production thereof.

Abstract translation: 本发明涉及来自S.koganeiensis的透明质酸酶，其应用及其生产方法。

公开(公告)号：WO2016016847A1

公开(公告)日：2016-02-04

申请号：PCT/IB2015/055782

申请日：2015-07-30

Applicant: SCIUTO, Sebastiano ,  CONSIGLIO NAZIONALE DELLE RICERCHE ,  FIDIA FARMACEUTICI S.P.A.

Inventor： SCIUTO, Sebastiano ,  GRECO, Valentina ,  RIZZARELLI, Enrico ,  BELLIA, Francesco ,  LANZA, Valeria ,  VACCARO, Susanna ,  MESSINA, Luciano

IPC: A61K47/48

CPC classification number: C08B37/0072 ,  A61K47/542 ,  A61K47/61 ,  C07D233/64

Abstract: The present invention relates to a derivative of carnosine (β-alanyl-L-histidine) having formula (1), obtained by the functionalization of hyaluronic acid with carnosine.

Abstract translation: 本发明涉及通过将谷氨酸与透明质酸官能化而获得的具有式（1）的肌肽（β-丙氨酰-L-组氨酸）的衍生物。

公开(公告)号：WO2010130810A1

公开(公告)日：2010-11-18

申请号：PCT/EP2010/056596

申请日：2010-05-12

Applicant: FIDIA FARMACEUTICI S.P.A. ,  MESSINA, Luciano ,  VACCARO, Susanna ,  CARUSO, Salvatore ,  GENNARI, Giovanni

Inventor： MESSINA, Luciano ,  VACCARO, Susanna ,  CARUSO, Salvatore ,  GENNARI, Giovanni

IPC: C12N9/26 ,  C07K14/315

CPC classification number: C12N9/2474 ,  A61K38/00 ,  A61K38/47 ,  A61K39/35 ,  A61K45/06 ,  C07K14/315 ,  C07K14/43595 ,  C12N9/2408 ,  C12Y302/01035

Abstract: The invention relates to Streptomyces koganeiensis ATCC 31394 hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date. The invention further relates to a process for the isolation and purification of said hyaluronidase and its use for the preparation of pharmaceutical compositions or as an analytical reagent.

Abstract translation: 本发明涉及分子量为21.6kDalton的koganeiensis链霉菌ATCC 31394透明质酸酶，其透明质酸酶活性和稳定性明显高于迄今为止从该微生物获得的透明质酸酶的稳定性。 本发明还涉及用于分离和纯化所述透明质酸酶的方法及其用于制备药物组合物或作为分析试剂的用途。

公开(公告)号：WO2019069258A1

公开(公告)日：2019-04-11

申请号：PCT/IB2018/057697

申请日：2018-10-03

Applicant: FIDIA FARMACEUTICI S.P.A.

Inventor： SCHIAVINATO, Antonella ,  GRECO, Valentina ,  MESSINA, Luciano ,  VACCARO, Susanna ,  RIZZARELLI, Enrico ,  SCIUTO, Sebastiano

IPC: A61K47/61 ,  A61K47/54 ,  A61P29/00

Abstract: Pharmaceutical compositions are described containing Hyaluronic Acid and Carnosine for use in the treatment and prevention of osteoarthritis (OA) and for the treatment of rheumatoid arthritis (RA).

公开(公告)号：WO2012032154A1

公开(公告)日：2012-03-15

申请号：PCT/EP2011/065642

申请日：2011-09-09

Applicant: FIDIA FARMACEUTICI S.P.A. ,  CORSA, Vincenza ,  NEGRO, Alessandro ,  VACCARO, Susanna ,  MESSINA, Luciano

Inventor： CORSA, Vincenza ,  NEGRO, Alessandro ,  VACCARO, Susanna ,  MESSINA, Luciano

IPC: C08B37/00 ,  C12N9/10 ,  C12P19/04 ,  C12P19/26 ,  C12N15/63 ,  C12N15/75

CPC classification number: C12P19/26 ,  C08B37/0072 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1051 ,  C12N9/1241 ,  C12N9/92 ,  C12N15/635 ,  C12N15/75 ,  C12Y101/01022 ,  C12Y204/01212 ,  C12Y207/07009 ,  C12Y503/01009

Abstract: The present invention relates to a method for the production of hyaluronic acid (HA) in Bacillus subtilis and Escherichia coli through plasmid vectors wherein the gene is under the control of strong promoter P grac , and a system for the selection of stable bacterial strains for the production of high levels of hyaluronic acid.

Abstract translation: 本发明涉及通过质粒载体在枯草芽孢杆菌和大肠杆菌中生产透明质酸（HA）的方法，其中该基因处于强启动子Pgrac的控制下，以及用于选择用于生产的稳定细菌菌株的系统 的高水平透明质酸。