公开(公告)号：WO1996029987A1

公开(公告)日：1996-10-03

申请号：PCT/US1996003813

申请日：1996-03-20

Applicant: FOCAL, INC.

Inventor： FOCAL, INC. ,  BAKER, Keith ,  COURY, Arthur, J.

IPC: A61K09/00

CPC classification number: A61K9/0024 ,  A61K38/44 ,  A61K38/446 ,  A61K47/32 ,  Y10S514/944 ,  Y10S514/963

Abstract: SOD and other active oxygen inhibitors are directly applied in combination with a barrier material at local sites of tissue injury to prevent or decrease formation of adhesions and undesirable profileration of cells. Preferred barrier materials are polymeric hydrogels providing controlled release of AOI which are directly applied to the afflicted tissue. Examples demonstrate the effects of SOD on pelvic adhesions in the rat when administered by intraperitoneal (I.P.) bolus and by localized sustained release from a topically applied hydrogel system.

Abstract translation: SOD和其他活性氧抑制剂直接与局部组织损伤部位的阻隔材料结合使用，以防止或减少粘连的形成和细胞的不希望的分泌。 优选的阻隔材料是提供直接施用于受影响组织的AOI的受控释放的聚合物水凝胶。 实施例证明当通过腹膜内（I.P.）推注和通过局部持续释放从局部施用的水凝胶系统施用时，SOD对大鼠骨盆粘连的影响。