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1.发明申请
公开(公告)号：WO2015170325A2
公开(公告)日：2015-11-12
申请号：PCT/IL2015/050469
申请日：2015-05-04
发明人： PALDI, Nitzan , BONCRISTIANI JUNIOR, Humberto Freire , MAORI, Eyal , WELLNER, Alon , ILAN, Shaul
IPC分类号： C12N15/82
CPC分类号： C12N15/1138 , A01K67/0339 , A01K2217/07 , A01K2227/706 , A01K2267/02 , A01N25/002 , A01N25/006 , A01N25/02 , A01N25/10 , A01N57/16 , A01N63/00 , A01N65/03 , C07K14/415 , C12N15/113 , C12N15/1137 , C12N15/8218 , C12N15/8243 , C12N15/8245 , C12N15/8261 , C12N15/827 , C12N15/8271 , C12N15/8273 , C12N15/8281 , C12N2310/14 , C12N2320/30 , C12N2320/32 , C12N2320/35
摘要： The present invention, in some embodiments thereof, relates to methods for enhancing fitness of pathogen-infected plants, and, more particularly, but not exclusively, to methods of using RNA interference for modulation of plant-pathogen resistance response gene expression. In particular, the present invention provides compositions and methods for enhancing host plant fitness and fruit yield and quality following Candidatus Liberibacter spp infection and, specifically, Candidatus Liberibacter spp infection in citrus plants and trees, as in Huang Long Bing.
摘要翻译： 本发明在其一些实施方案中涉及用于增强病原体感染植物的适应性的方法，更具体地但不排他地涉及使用RNA干扰来调节植物 - 病原体抗性应答基因表达的方法。 特别地，本发明提供了用于提高柑橘类植物和树木中Candidatus Liberibacter spp感染后的宿主植物适应度，果实产量和质量的组合物和方法，特别是黄龙炳中柑橘类植物和树木中的Candidatus Liberibacter spp感染。
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2.发明申请
公开(公告)号：WO2015170320A3
公开(公告)日：2015-11-12
申请号：PCT/IL2015/050464
申请日：2015-05-04
发明人： PALDI, Nitzan , BONCRISTIANI JUNIOR, Humberto Freire , MAORI, Eyal , WEISS, Avital , BERNARDES, Emerson Soares
IPC分类号： C12N15/113
摘要： A method of controlling a pathogenically infected mosquito is disclosed. The method comprising administering to a larva of a mosquito an isolated nucleic acid agent comprising a nucleic acid sequence which specifically downregulates an expression of at least one mosquito pathogen resistance gene product of the mosquito, wherein downregulation of the expression of the at least one mosquito pathogen resistance gene in the larvae renders an adult stage of the mosquito lethally susceptible to the pathogen, thereby controlling the pathogenically infected mosquito.
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公开(公告)号：WO2015170324A2
公开(公告)日：2015-11-12
申请号：PCT/IL2015/050468
申请日：2015-05-04
发明人： PALDI, Nitzan , BONCRISTIANI JUNIOR, Humberto Freire , MAORI, Eyal , WEISS, Avital , BERNARDES, Emerson Soares
IPC分类号： C12N15/113
CPC分类号： C12N15/1138 , A01K67/0339 , A01K2217/07 , A01K2227/706 , A01K2267/02 , A01N25/002 , A01N25/006 , A01N25/02 , A01N25/10 , A01N57/16 , A01N63/00 , A01N65/03 , C07K14/415 , C12N15/113 , C12N15/1137 , C12N15/8218 , C12N15/8243 , C12N15/8245 , C12N15/8261 , C12N15/827 , C12N15/8271 , C12N15/8273 , C12N15/8281 , C12N2310/14 , C12N2320/30 , C12N2320/32 , C12N2320/35
摘要： A composition-of-matter for mosquito control is provided. The composition comprises a cell which comprises an exogenous naked dsRNA which specifically down- regulates expression of a gene being endogenous to a mosquito or which specifically down-regulated expression of a gene being endogenous to a mosquito pathogen. Further provided is a composition-of-matter for mosquito control, comprising a cell comprising a nucleic acid larvicide. Also provided are methods of producing and using the compositions.
摘要翻译： 提供了一种用于灭蚊控制的物质组成。 组合物包含细胞，其包含特异性下调蚊子内源基因表达的外源性裸dsRNA，或特异性下调蚊子病原体内源基因的表达。 还提供了一种用于灭蚊控制的物质组合物，其包括含有核酸杀幼虫剂的细胞。 还提供了生产和使用组合物的方法。
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4.发明申请COMPOSITIONS AND METHODS OF USING SAME FOR REDUCING RESISTANCE TO MOSQUITO LARVICIDES 审中-公开使用它们的组合物和方法用于降低对MOSQUITO LARVICID的电阻
公开(公告)号：WO2015170323A2
公开(公告)日：2015-11-12
申请号：PCT/IL2015/050467
申请日：2015-05-04
发明人： PALDI, Nitzan , BONCRISTIANI JUNIOR, Humberto Freire , MAORI, Eyal , WEISS, Avital , BERNARDES, Emerson Soares
IPC分类号： C12N15/113
CPC分类号： C12N15/1138 , A01K67/0339 , A01K2217/07 , A01K2227/706 , A01K2267/02 , A01N25/002 , A01N25/006 , A01N25/02 , A01N25/10 , A01N57/16 , A01N63/00 , A01N65/03 , C07K14/415 , C12N15/113 , C12N15/1137 , C12N15/8218 , C12N15/8243 , C12N15/8245 , C12N15/8261 , C12N15/827 , C12N15/8271 , C12N15/8273 , C12N15/8281 , C12N2310/14 , C12N2320/30 , C12N2320/32 , C12N2320/35
摘要： A method of enhancing larvicide susceptibility in a mosquito larva is provided. The method comprising introducing into the mosquito larva an isolated nucleic acid agent comprising a nucleic acid sequence which specifically reduces the expression of at least one larvicide resistance gene product of the larva, thereby enhancing larvicide susceptibility in said mosquito larva.
摘要翻译： 提供了一种提高蚊子幼虫易感性的方法。 该方法包括向蚊子幼虫中引入分离的核酸试剂，所述分离的核酸试剂特异性地降低幼虫的至少一种杀幼虫抗性基因产物的表达，从而提高所述蚊虫幼虫的幼虫抗性。
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5.发明申请COMPOSITIONS AND METHODS OF USING SAME FOR INCREASING RESISTANCE OF INFECTED MOSQUITOES 审中-公开组合物及其使用方法增加感染性金黄色葡萄球菌的耐药性
公开(公告)号：WO2015170322A2
公开(公告)日：2015-11-12
申请号：PCT/IL2015/050466
申请日：2015-05-04
发明人： PALDI, Nitzan , BONCRISTIANI JUNIOR, Humberto Freire , MAORI, Eyal , WEISS, Avital , BERNARDES, Emerson Soares
IPC分类号： C12N15/113
CPC分类号： C12N15/1138 , A01K67/0339 , A01K2217/07 , A01K2227/706 , A01K2267/02 , A01N25/002 , A01N25/006 , A01N25/02 , A01N25/10 , A01N57/16 , A01N63/00 , A01N65/03 , C07K14/415 , C12N15/113 , C12N15/1137 , C12N15/8218 , C12N15/8243 , C12N15/8245 , C12N15/8261 , C12N15/827 , C12N15/8271 , C12N15/8273 , C12N15/8281 , C12N2310/14 , C12N2320/30 , C12N2320/32 , C12N2320/35
摘要： A method of enhancing resistance of a mosquito to a pathogen is disclosed. The method comprising administering to a mosquito an isolated nucleic acid agent comprising a nucleic acid sequence which specifically downregulates an expression of at least one mosquito or pathogen gene wherein a product of said mosquito or pathogen gene participates in infection and/or growth of the pathogen in the mosquito.
摘要翻译： 公开了提高蚊子对病原体的抗性的方法。 该方法包括向蚊子施用分离的核酸试剂，其包含特异性下调至少一种蚊子或病原体基因的表达的核酸序列，其中所述蚊子或病原体基因的产物参与所述病原体的感染和/或生长 蚊子。
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