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    USE OF MEDEA ELEMENTS FOR BIOCONTROL OF D. SUZUKII POPULATIONS
    2.
    发明申请
    USE OF MEDEA ELEMENTS FOR BIOCONTROL OF D. SUZUKII POPULATIONS 审中-公开
    MEDEA元素在D.suzukii群生物控制中的应用

    公开(公告)号：WO2017132207A1

    公开(公告)日：2017-08-03

    申请号：PCT/US2017/014846

    申请日：2017-01-25

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： AKBARI, Omar, S. ,  BUCHMAN, Anna

    IPC分类号： A01K67/033 ,  C12N15/85 ,  C12N15/90

    CPC分类号： A01K67/033 ,  A01K67/0339 ,  A01K2217/052 ,  A01K2217/30 ,  A01K2227/706 ,  A01K2267/01 ,  A01N63/02 ,  C07K14/43581 ,  C07K14/4702 ,  C07K2319/55 ,  C12N15/113 ,  C12N15/90 ,  C12N2310/141 ,  C12N2310/20 ,  C12N2830/008

    摘要： An insect gene drive system for biocontrol of a population of an insect is provided. The gene drive system includes: a) a first DNA sequence encoding a toxin under the control of a maternal germline-specific promoter active in the insect, with the first DNA sequence being linked to b) a second DNA sequence encoding an antidote under the control of an early embryo-specific promoter active in the insect. The toxin is expressed in maternal germline cells of the insect and results in maternal-effect lethality in the insect, and the antidote is expressed in embryos of the insect and counters the maternal -effect lethality. In some embodiments, the insect is Drosophila suzukii.

    摘要翻译： 提供了用于生物防治昆虫种群的昆虫基因驱动系统。 该基因驱动系统包括：a）编码在昆虫中有活性的母系种系特异性启动子控制下的毒素的第一DNA序列，其中第一DNA序列与b）编码控制下的解毒剂的第二DNA序列连接 的在昆虫中有活性的早期胚胎特异性启动子。 毒素在昆虫的母系生殖细胞中表达并导致昆虫的母体效应致死性，并且解毒剂在昆虫的胚胎中表达并抵抗母体效应致死性。 在一些实施方案中，昆虫是果蝇。

    ALL STERILE MALES OF CULICINE MOSQUITOES: A METHOD OF CREATION
    3.
    发明申请
    ALL STERILE MALES OF CULICINE MOSQUITOES: A METHOD OF CREATION 审中-公开
    CULICINE MOSQUITOES的所有无精子症：创造的方法

    公开(公告)号：WO2016007975A1

    公开(公告)日：2016-01-14

    申请号：PCT/VN2014/000004

    申请日：2014-07-07

    申请人： HOANG, Duong Thanh

    发明人： HOANG, Duong Thanh ,  HOANG, Kim Phuc

    IPC分类号： A01K67/033 ,  C12N15/113

    CPC分类号： A01K67/0339 ,  A01K2207/05 ,  A01K2217/05 ,  A01K2217/20 ,  A01K2217/206 ,  A01K2227/706 ,  A01K2267/02 ,  C12N15/111 ,  C12N15/113 ,  C12N15/85 ,  C12N2310/14

    摘要： An all male Culicide mosquito population is created by knocking down its Transformer-2 gene, causing the dysfunction of X chromosome-bearing sperm, hence producing severe biased male progenies. Unlike previous methods, we recently discovered that the Tra-2 knockdown also results in female- specific zygotes lethality (XX). This art is therefore also designed to kill early female zygotes (XX) that may have survived the previous knockdown, and the all male progenies are created only when an antibiotic substance has been added into food and drink to feed mosquitoes. The strict limit of the antibiotic exposure time allows mosquito-adapted Wolbachia bacteria to survive. Selected Wolbachia bacteria may induce cytoplasmic incompatibility (CI) of up to 100%. All the progenies are therefore genetically males, which cause sterility when outcrossing with females infected by another Wolbachia strain (bidirectional CI) or are uninfected (unidirectional CI) in natural environment.

    摘要翻译： 通过击倒其Transformer-2基因，导致X染色体携带精子的功能障碍，从而产生严重偏倚的男性后代，所有男性Culicide蚊子群体都是创造的。 与以前的方法不同，我们最近发现Tra-2敲除也导致女性特异性合子致死率（XX）。 因此，这种艺术也被设计用于杀死可能在之前的击倒中幸存的早期雌性受精卵（XX），并且所有男性后代仅在将抗生素物质添加到食物和饮料中才能产生蚊子时产生。 抗生素暴露时间的严格限制允许蚊子适应的Wolbachia细菌存活。 所选Wolbachia细菌可诱导高达100％的细胞质不相容性（CI）。 所有后代因此是遗传性雄性，当与自然环境中的另一种Wolbachia菌株（双向CI）感染的雌性或未感染（单向CI）异交时，其导致不育。

    STABLE TRANSFORMATION OF A POPULATION AND A METHOD OF BIOCONTAINMENT USING HAPLOINSUFFICIENCY AND UNDERDOMINANCE PRINCIPLES
    7.
    发明申请
    STABLE TRANSFORMATION OF A POPULATION AND A METHOD OF BIOCONTAINMENT USING HAPLOINSUFFICIENCY AND UNDERDOMINANCE PRINCIPLES 审中-公开
    人口的稳定转型和利用生物多样性和不良原则的生物量化方法

    公开(公告)号：WO2014096428A1

    公开(公告)日：2014-06-26

    申请号：PCT/EP2013/077856

    申请日：2013-12-20

    申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

    发明人： REEVES, Guy ,  REED, Floyd

    IPC分类号： A01H1/00 ,  A01K67/033

    CPC分类号： A01H1/02 ,  A01H1/00 ,  A01K67/033 ,  A01K67/0333 ,  A01K67/0339 ,  A01K2207/05 ,  A01K2217/15 ,  A01K2227/706 ,  A01K2267/02 ,  C12N15/113 ,  C12N15/8218 ,  C12N2310/14 ,  Y02A90/40

    摘要： The present invention relates to a method for reducing the competitive fitness of an organism hemizygous for a transgenic locus compared to the organism homozygous for the transgenic locus comprising the steps of:(a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; and (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, yielding an organism which is less competitively fit if hemizygous for the transgenic locus than if homozygous for the transgenic locus. The present invention also relates to a method for decreasing the introgression of a transgenic locus in an organism into a population of otherwise interfertile sexually reproducing organisms comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, and (c) using a transgenic organism obtained in step (b) in an environment comprising otherwise interfertile sexually reproducing wildtype individuals of the organism, wherein the competitive fitness of hemizygous progeny is reduced, thereby decreasing the rate of sexually reproduction and/or viability and/or the competitive fitness of hemizygous progeny. Further envisaged are corresponding genetic systems and genetically modified organisms.

    摘要翻译： 本发明涉及一种用于降低与转基因座位纯合的生物体相比转基因基因座的竞争适应度的方法，该方法包括以下步骤：（a）降低生物体中不存在足够的基因的表达，其中所述 由生物体中的转基因位点传递减少; 并且（b）拯救生物体中的减少的表达，其中所述拯救由生物体中相同的转基因位点传递，产生如果对于转基因基因座是半合子的竞争性适合的生物体，如果对于转基因基因座是纯合的。 本发明还涉及一种用于将生物体中的转基因基因座的渐渗作用降低到否则干扰性性再生生物群体的方法，所述方法包括以下步骤：（a）降低所述生物体中不存在足够的基因的表达，其中所述还原 由生物体中的转基因位点传递; （b）拯救生物中的表达减少，其中所述营救由生物体内相同的转基因位点传递，和（c）使用步骤（b）中得到的转基因生物体在包括另外干扰性性繁殖野生型个体的环境中 有机体，其中半合子后代的竞争适应性降低，从而降低了半合子后代的性生殖和/或活力和/或竞争适应性的速率。 进一步设想的是相应的遗传系统和转基因生物。