中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

16 records (took 0.016 seconds)

    TRANSPARENT COOLING GEL
    2.
    发明申请
    TRANSPARENT COOLING GEL 审中-公开
    透明冷胶

    公开(公告)号：WO2009046820A3

    公开(公告)日：2009-12-30

    申请号：PCT/EP2008007789

    申请日：2008-09-17

    Applicant: FRESENIUS KABI DE GMBH ,  MUELLER BERND-W ,  SOMMERMEYER KLAUS

    Inventor： MUELLER BERND-W ,  SOMMERMEYER KLAUS

    IPC: A01N1/02

    CPC classification number: A01N1/021 ,  A01N1/02

    Abstract: For cooling organs and tissue in transplantation medicine, only ice preparations are used, which are not gelatinously soft and are brought from frozen, sterile, pyrogen-free, isotonic infusion solutions, such as 5% glucose or 0.9% salt solution, to the required degree of comminution by expensive mechanical disintegration. The lack of gel-like properties of the preparations and the expensive manufacturing process are very disadvantageous. There was therefore a need for the production of a cooling preparation for transplantation medicine, which is gelatinous, transparent and adequately stable mechanically at temperatures ranging from -5°C to 4°C and nevertheless remains moldable. According to the invention, such a preparation can be produced from gelatin solutions ranging in concentration form 3 to 20% by weight, which have been isotonized or adjusted with electrolytes to 280 - 650 mosmol/kg and have an almost neutral pH, simply by cooling or freezing.

    Abstract translation: 在移植医学仅Eispräparationen是用于冷却所述器官和组织迄今使用，这是不凝胶状软并从冷冻，无菌，无热原的，等渗输注溶液如葡萄糖5％或0.9％盐水溶液通过消耗机械粉碎到所需的程度的粉碎的 被带来。 制剂缺乏凝胶性和复杂的生产过程是非常不利的。 有因此建立用于移植的冷却制备，其为凝胶状柔软，透明和机械的温度范围为-5℃至4℃下足够稳定，但仍然柔韧的需要。 至650 mosmol / kg的等渗或调节和接近中性pH值，通过简单的冷却或冷冻制备 - 按重量计20％时，电解质280 .. - 这样的制备根据本发明的可以由在3浓度范围的明胶溶液的

    WATER-SOLUBLE ANTIBIOTIC COMPRISING AN AMINO SUGAR, IN THE FORM OF A POLYSACCHARIDE CONJUGATE
    7.
    发明申请
    WATER-SOLUBLE ANTIBIOTIC COMPRISING AN AMINO SUGAR, IN THE FORM OF A POLYSACCHARIDE CONJUGATE 审中-公开
    多糖共轭物形式的水溶性，基于氨基糖的抗生素

    公开(公告)号：WO03000738A3

    公开(公告)日：2003-08-28

    申请号：PCT/EP0206764

    申请日：2002-06-19

    Applicant: FRESENIUS KABI DE GMBH ,  SOMMERMEYER KLAUS

    Inventor： SOMMERMEYER KLAUS

    IPC: A61K47/48 ,  A61P31/10 ,  A61P35/00 ,  C08B31/00 ,  C08B31/04 ,  C08B31/08 ,  C08B31/12 ,  C08B31/16 ,  C08B33/00 ,  C08B33/02 ,  C08B33/04 ,  C08B33/06 ,  C08B35/00 ,  C08B35/02 ,  C08B35/04 ,  C08B35/06

    CPC classification number: C08B35/06 ,  A61K47/61 ,  C08B31/00 ,  C08B31/04 ,  C08B31/08 ,  C08B31/125 ,  C08B31/16 ,  C08B33/00 ,  C08B33/02 ,  C08B33/04 ,  C08B33/06 ,  C08B35/00 ,  C08B35/02 ,  C08B35/04

    Abstract: The invention relates to novel pharmaceutical forms for antibiotics containing amino sugar, amphotericin B, daunorubicin and doxorubicin, in which the known side effects are reduced and which can be used in a simple manner. The antimycotic agent B is nephrotoxic. The cytostatic agents daunorubicin and doxorubicin are highly cardiotoxic. The novel pharmaceutical forms are antibiotic-starch conjugates, wherein the antibiotic is combined with the polysaccharide at the reducing end thereof by means of a peptide bond. According to the invention, said bond is carried out by means of J2-oxidation of the starch derivative at the reducing end thereof in an aqueous alkaline solution, and by coupling the starch derivative oxidised thereby to the antibiotic in an organic solution. The conjugates obtained are less toxic. The polysaccharide part can be decomposed by serum- alpha -amylase and the peptide bond can be accessed by an enzymatic attack.

    Abstract translation: 应该提供氨基糖抗生素两性霉素B，柔红霉素和多柔比星的新剂型，其中已知的副作用减少并且是直接的。 抗真菌两性霉素B是肾毒性的。 抑制细胞生长的柔红霉素和多柔比星具有高度的心脏毒性。 新的剂型是抗生素 - 淀粉缀合物，其中抗生素通过肽键与其还原末端的多糖连接。 根据该方法，该结合通过淀粉衍生物在其还原端在含水碱性溶液中的J 2氧化发生，并随后将如此氧化的淀粉衍生物偶联到有机溶液中的抗生素上。 得到的结合物毒性较小。 多糖部分可被血清α-淀粉酶降解，并且肽键易受酶促攻击。

    PARACETAMOL SOLUTIONS WHICH ARE STABLE IN STORAGE AND READY FOR INFUSION
    10.
    发明申请
    PARACETAMOL SOLUTIONS WHICH ARE STABLE IN STORAGE AND READY FOR INFUSION 审中-公开
    对乙酰氨基酚的贮存稳定就绪解决方案输液

    公开(公告)号：WO02072080A3

    公开(公告)日：2002-11-28

    申请号：PCT/EP0202696

    申请日：2002-03-12

    Applicant: FRESENIUS KABI DE GMBH ,  ESCHENBACH BERND ,  MUELLER HANS-JOERG ,  SOMMERMEYER KLAUS

    Inventor： ESCHENBACH BERND ,  MUELLER HANS-JOERG ,  SOMMERMEYER KLAUS

    IPC: A61K9/08 ,  A61K31/167 ,  A61K31/46 ,  A61K31/485 ,  A61K45/06 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22 ,  A61K31/165

    CPC classification number: A61K9/0019 ,  A61K9/08 ,  A61K31/167 ,  A61K31/46 ,  A61K31/485 ,  A61K45/06 ,  A61K47/183 ,  A61K47/20 ,  A61K47/22 ,  A61K2300/00

    Abstract: The invention relates to parenterally administrable, especially infusible, aqueous paracetamol solutions which are stable in storage and free of particles and discoloration. Said solutions contain a mixture of: a) between 1 and 17 grams of paracetamol per litre, and b) between 0.01 and 0.17 grams of at least one physiologically compatible antioxidant per litre, selected from the group comprising ascorbic acid, N-acetyl-L-cysteine and stabiliser compounds containing SH groups which are different from N-acetyl-L-cysteine. The aqueous solution is free of organic solvents and has a pH value of between 5.5 and 6.5 and an oxygen content of less than 0.5 milligrams per litre. The invention also relates to a method for producing such solutions, and glass or plastic containers containing said solutions.

    Abstract translation: 所公开的是储存稳定的，颗粒和不变色的，可肠胃外施用，特别是难熔的，对乙酰氨基酚的水溶液，其包含在混合物：a）第1至17克每公升对乙酰氨基酚，和b）从每升一种或多种生理的0.01至0.17克 选自抗坏血酸，N-乙酰基-L-半胱氨酸和含有SH基的稳定剂化合物，其是从N-乙酰基-L-半胱氨酸不同的组中的可接受的抗氧化剂; 其中所述水溶液不含有机溶剂和具有在5.5至6.5范围内的pH值和每升少于0.50毫克的氧含量。 一种用于由玻璃或者含有这种溶液的塑料这样的解决方案，以及容器的制备方法被公开。

Patent Agency Ranking