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公开(公告)号：WO2017114859A1
公开(公告)日：2017-07-06
申请号：PCT/EP2016/082770
申请日：2016-12-28
Applicant: GALDERMA S.A.
Inventor： OLSSON, Johan , HARRIS, Craig Steven
CPC classification number: C08B37/0063 , C08B37/0069 , C08B37/0072 , C08J3/075 , C08J2305/00 , C08L5/00
Abstract: A method for cleaving amide bonds, comprising: a) providing a molecule comprising an amide group; b) reacting the molecule comprising an amide group with hydroxylamine (NH 2 OH) or a salt thereof to cleave the amide bond of the amide group.
Abstract translation: 一种用于切割酰胺键的方法，其包括：a）提供包含酰胺基团的分子; b）使包含酰胺基团的分子与羟胺（NH 2 OH）或其盐反应以切割酰胺基团的酰胺键。
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公开(公告)号：WO2017114864A1
公开(公告)日：2017-07-06
申请号：PCT/EP2016/082778
申请日：2016-12-28
Applicant: GALDERMA S.A.
Inventor： OLSSON, Johan , HARRIS, Craig Steven
CPC classification number: C08B37/0063 , C08B37/0069 , C08B37/0072 , C08J3/075 , C08J2305/00 , C08L5/00
Abstract: A method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules, said method comprising: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans comprise residual amine groups; and ii) acylating residual amine groups of the crosslinked glycosaminoglycans provided in i) to form acylated crosslinked glycosaminoglycans.
Abstract translation: 一种制备包含交联糖胺聚糖分子的水凝胶产品的方法，所述方法包括：i）提供通过酰胺键交联的糖胺聚糖，其中所述交联糖胺聚糖包含残余胺基; 和ii）酰化i）中提供的交联糖胺聚糖的残基胺基以形成酰化交联糖胺聚糖。
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Patent Agency Ranking
公开(公告)号：WO2017207564A1
公开(公告)日：2017-12-07
申请号：PCT/EP2017/063029
申请日：2017-05-30
Applicant: GALDERMA S.A.
Inventor： OLSSON, Johan , HARRIS, Craig, Steven
CPC classification number: C08B37/0063 , C08B37/0069 , C08B37/0072 , C08J3/075 , C08L5/00
Abstract: a) providing a molecule comprising an amide group; b) reacting the molecule comprising an amide group with a hydroxylamine salt to cleave the amide bond of the amide group.
Abstract translation: a）提供包含酰胺基团的分子; b）使包含酰胺基团的分子与羟胺盐反应以切割酰胺基团的酰胺键。
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公开(公告)号：WO2017114867A1
公开(公告)日：2017-07-06
申请号：PCT/EP2016/082783
申请日：2016-12-28
Applicant: GALDERMA S.A.
Inventor： OLSSON, Johan , HARRIS, Craig Steven
CPC classification number: C08B37/0063 , C08B37/0069 , C08B37/0072 , C08J3/075 , C08J2305/00 , C08L5/00
Abstract: The invention relates to a hydrogel product comprising glycosaminoglycan molecules as the swellable polymer, wherein the glycosaminoglycan molecules are covalently crosslinked via crosslinks comprising a spacer group selected from the group consisting of di-, tri-, tetra-, and oligosaccharides.
Abstract translation: 本发明涉及包含作为可溶胀聚合物的糖胺聚糖分子的水凝胶产品，其中糖胺聚糖分子通过包含选自二 - ，三 - ，四 - ，和低聚糖。
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公开(公告)号：WO2017114861A1
公开(公告)日：2017-07-06
申请号：PCT/EP2016/082774
申请日：2016-12-28
Applicant: GALDERMA S.A.
Inventor： OLSSON, Johan , HARRIS, Craig Steven
CPC classification number: C08B37/0063 , C08B37/0069 , C08B37/0072 , C08J3/075 , C08J2305/00 , C08L5/00
Abstract: A method for at least partial deacetylation of a biopolymer comprising acetyl groups, comprising: a1 ) providing a biopolymer comprising acetyl groups; a2) reacting the biopolymer comprising acetyl groups with hydroxylamine (NH 2 OH) or a salt thereof at a temperature of 100 °C or less for 2-200 hours to form an at least partially deacetylated biopolymer; and a3) recovering the at least partially deacetylated biopolymer.
Abstract translation: 一种用于使包含乙酰基的生物聚合物至少部分脱乙酰化的方法，其包括：a1）提供包含乙酰基的生物聚合物; a2）使包含乙酰基的生物聚合物与羟胺（NH 2 OH）或其盐在100℃或更低的温度下反应2-200小时以形成至少部分脱乙酰化的生物聚合物; 和a3）回收至少部分脱乙酰的生物聚合物。
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公开(公告)号：WO2016107873A1
公开(公告)日：2016-07-07
申请号：PCT/EP2015/081353
申请日：2015-12-29
Applicant: GALDERMA S.A.
Inventor： BERGMAN, Kristoffer , OLSSON, Johan
CPC classification number: C08B37/0072 , A61L27/20 , C08B37/0021 , C08B37/0069 , C08G81/00
Abstract: A graft copolymer comprising: a core polymer comprising a crosslinked or non-crosslinked polysaccharide,a plurality of primary graft polymers covalently grafted to the core polymer,a plurality of secondary graft polymers covalently grafted to each primary graft polymer, an injectable dermal aesthetic formulation comprising such a graft copolymer and a method of preparing such a graft copolymer.
Abstract translation: 一种接枝共聚物，其包含：包含交联或未交联的多糖的核心聚合物，共价接枝到芯聚合物上的多个主接枝聚合物，共价接枝到每个主接枝聚合物上的多个第二接枝聚合物，可注射的真皮美容制剂，其包含 这种接枝共聚物和制备这种接枝共聚物的方法。
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公开(公告)号：WO2017114865A1
公开(公告)日：2017-07-06
申请号：PCT/EP2016/082781
申请日：2016-12-28
Applicant: GALDERMA S.A.
Inventor： OLSSON, Johan , HARRIS, Craig Steven
CPC classification number: C08B37/0063 , C08B37/0069 , C08B37/0072 , C08J3/075 , C08J2305/00 , C08L5/00
Abstract: A method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules, said method comprising: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans comprise ester crosslinks formed as byproducts during the amide crosslinking; and ii) subjecting the crosslinked glycosaminoglycans to alkaline treatment to hydrolyze ester crosslinks formed as byproducts during the amide crosslinking.
Abstract translation: 制备包含交联糖胺聚糖分子的水凝胶产品的方法，所述方法包括：i）提供通过酰胺键交联的糖胺聚糖，其中所述交联糖胺聚糖包含在酰胺交联过程中作为副产物形成的酯交联; 和ii）使交联的糖胺聚糖进行碱处理以水解在酰胺交联期间作为副产物形成的酯交联。
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