公开(公告)号：WO2023064489A1

公开(公告)日：2023-04-20

申请号：PCT/US2022/046598

申请日：2022-10-13

申请人： GALILEO BIOSYSTEMS, INC.

发明人： HOWELL, Michael ,  COHEN, Steven, Bruce ,  STOUT, Elizabeth, Paige ,  MACHERLA, Venkata Rami Reddy ,  BARAN, Phil, S. ,  ESQUENAZI, Eduardo ,  SCHWENT, Tamara

IPC分类号： A61K31/517 ,  A61P17/06 ,  A61P29/00 ,  C07D487/14

摘要： The present application is directed towards the provision of compounds of formula I, pharmaceutical compositions and methods of treatment thereof. Also disclosed are methods of treating a disease comprising the compounds of formula II. The compounds of the invention are modulators of aryl hydrocarbon receptor (AhR) and find use in the treatment of dermatologic, respiratory, oncologic, autoimmune or immunologic disease.

公开(公告)号：WO2023064486A1

公开(公告)日：2023-04-20

申请号：PCT/US2022/046595

申请日：2022-10-13

申请人： GALILEO BIOSYSTEMS, INC.

发明人： HOWELL, Michael ,  COHEN, Steven, Bruce ,  STOUT, Elizabeth, Paige ,  MACHERLA, Venkata Rami Reddy ,  BARAN, Phil, S. ,  ESQUENAZI, Eduardo ,  SCHWENT, Tamara ,  BARMARE, Farhana

IPC分类号： C07D403/06 ,  C07D471/04 ,  A61K31/4184 ,  A61K31/437 ,  A61P17/06 ,  A61P29/00

摘要： Disclosed herein are small molecule aryl hydrocarbon receptor (AhR) modulator compositions, pharmaceutical compositions, the use and preparation thereof.