公开(公告)号：WO2022175982A1

公开(公告)日：2022-08-25

申请号：PCT/IN2022/050143

申请日：2022-02-18

Applicant: GBR LABORATORIES PRIVATE LIMITED

Inventor： GADDAM, Pratap Reddy ,  GADDAM, Samhitha Reddy ,  GADDAM, Madaalasa Reddy ,  MOSALI, Udaya Kumar Reddy

IPC: C07D471/04 ,  C07D401/12 ,  A61P11/00 ,  A61P11/08

Abstract: The present invention discloses a process for preparation of Batefenterol of Formula (I) or pharmaceutically acceptable salts thereof, and its intermediates by epoxidation. The process involves preparation of the intermediate compound of Formula (VII), followed by preparation of Batefenterol from the intermediate compound of Formula (VII) via intermediate compounds of Formulae (X) and (XI); or via intermediate compounds of Formulae (IX) and (XI); or via intermediate compounds of Formulae (VII) and (XI); or via intermediate compounds of the Formulae (XV) and (XVI); or via intermediate compounds of the Formulae (XIX) and (XVI). The process is cost effective and gives higher yield and better purity. The process does not use hypertoxic materials and yields compound (I) that is highly efficient and possess excellent powdery nature.

公开(公告)号：WO2022172296A1

公开(公告)日：2022-08-18

申请号：PCT/IN2022/050122

申请日：2022-02-12

Applicant: GBR LABORATORIES PRIVATE LIMITED

Inventor： GADDAM, Pratap Reddy ,  GADDAM, Samhitha Reddy ,  GADDAM, Madaalasa Reddy ,  MOSALI, Udaya Kumar Reddy

IPC: C07C17/00 ,  C07D403/12 ,  C07D409/14 ,  A61K31/4709

Abstract: The present invention relates to a process for preparation of Navafenterol of Formula (I) and intermediate compounds of Formula (VII) and Formula (XIII) by chiral sulfide mediated epoxidation. The process involves preparation of the intermediate compounds of Formula (VII) and Formula (XIII) followed by preparation of Navafenterol from the compound of Formula (XIII) either by condensation with the compound of Formula (XVI); or via intermediates of the compound of Formula (XVIII) and compound of Formula (XV); or via intermediates of the compound of Formula (XI-a) and compound of Formula (XVI). The process uses simple raw materials and reagents. Further, the process is cost effective and gives higher yield and better purity.

公开(公告)号：WO2022172292A1

公开(公告)日：2022-08-18

申请号：PCT/IN2022/050112

申请日：2022-02-09

Applicant: GBR LABORATORIES PRIVATE LIMITED

Inventor： GADDAM, Pratap Reddy ,  GADDAM, Samhitha Reddy ,  GADDAM, Madaalasa Reddy ,  MOSALI, Udaya Kumar Reddy

IPC: C07C217/10 ,  C07C215/30 ,  C07C217/26

Abstract: The present invention relates to a process for preparation of Abediterol of the Formula (I) or its pharmaceutically acceptable salts, and intermediate compounds including the compound of the Formula (VII) by chiral sulfide mediated epoxidation. The process involves preparation of the intermediate compounds followed by preparation of Abediterol from the intermediate compounds. The compound Abediterol having the formula I is synthesized by various routes from the intermediate compound of Formula (VII). The process is cost effective and gives higher yield and better purity. The process of the present invention uses simple raw materials and reagents; and does not use hypertoxic materials.