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公开(公告)号：WO2020058012A1
公开(公告)日：2020-03-26
申请号：PCT/EP2019/073926
申请日：2019-09-09
发明人： HINDUPUR, Sameera, Simha , RAMAKRISHNA, Manoj, Kumar , CASTAN, Andreas , PURANIK, Swapnil , GEBAUER, Klaus
摘要： The present invention relates to a computer implemented method for determining a weld integrity test result performed by a system configured to aseptically transferring cells to a container (BR), the method comprising welding (710) a vial to a connector to obtain a fluid-tight seal between the vial (V) and a connector (C), the connector being provided with a pair of conduits each having one end protruding through the connector and into the vial, sealing (720) an opposite end of one of the conduits, generating (730) a fluid pressure different to an ambient fluid pressure at an opposite end of the other conduit, measuring (740) a fluid pressure within at least one of the conduits, determining (750) a fluid pressure change based on the ambient pressure and the measured fluid pressure, determining (760) the weld integrity test result as pass or as fail based on the fluid pressure change.
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2.发明申请IMPROVED METHOD FOR ENHANCING FILTRATION YIELDS IN TANGENTIAL FLOW FILTRATION SYSTEM 审中-公开改进流量过滤系统中过滤网的改进方法
公开(公告)号：WO2017029307A1
公开(公告)日：2017-02-23
申请号：PCT/EP2016/069475
申请日：2016-08-17
发明人： NUTALAPATI, Sasi, Kumar , GEBAUER, Klaus , LIDERFELT, Karl, Axel, Jakob , KARMARKAR, Nachiket , VERNEKAR, Ajit S. , SHARMA, Amit, Kumar , LUNDSTROM, Fredrik, Oskar , RAGHU RAMACHANDRAN, Sangeetha
CPC分类号： B01D61/18 , B01D61/20 , B01D61/22 , B01D2315/10 , B01D2315/14 , B01D2311/08 , B01D2311/16 , B01D2311/25
摘要： The disclosure generally relates to methods and apparatus for the efficient quantitative recovery of valuable biological fluids from filtration systems, more particularly to efficient quantitative recovery of valuable biological fluids from high precision separation systems suitable for use in the pharmaceutical and biotechnology industries.
摘要翻译： 本公开一般涉及用于从过滤系统有效定量回收有价值生物流体的方法和装置，更具体地涉及从适用于制药和生物技术工业的高精度分离系统有效定量回收有价值的生物流体。
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公开(公告)号：WO2016015952A1
公开(公告)日：2016-02-04
申请号：PCT/EP2015/065311
申请日：2015-07-06
发明人： GEBAUER, Klaus , LUNDKVIST, Mats , OLOVSSON, Bjorn
CPC分类号： G01N30/6039 , B01D15/1864 , G01N30/465 , G01N30/468 , G01N30/6034 , G01N30/88 , G01N2030/027 , G01N2030/8881
摘要： The invention discloses a flow control block (221) for a stack of chromatography column modules (23, 23', 23", 23"'), as well as a stack of chromatography modules (23, 23', 23", 23"') comprising at least one flow control block (221). The flow control block (221) is in a first position or configuration capable of connecting two chromatography column modules (23,23'), or a chromatography column module (23,23"') and an endpiece (239), in parallel and in a second position or configuration it is capable of connecting two chromatography column modules, or a chromatography column module and an endpiece, in series.
摘要翻译： 本发明公开了一种用于色谱柱模块（23,23'，23“，23”'）的堆叠的流量控制块（221），以及一叠色谱模块（23,23'，23“，23” '）包括至少一个流量控制块（221）。 流量控制块（221）处于能够并联连接两个色谱柱模块（23,23'）或色谱柱模块（23,23“'）和端件（239）的第一位置或配置，以及 在第二个位置或配置中，它能够串联连接两个色谱柱模块或色谱柱模块和端件。
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4.发明申请SYSTEMS AND METHODS FOR STATUS INDICATION IN A SINGLE-USE BIOMEDICAL AND BIOPROCESS SYSTEM 审中-公开在单一生物医学和生物系统系统中用于状态指示的系统和方法
公开(公告)号：WO2015076741A1
公开(公告)日：2015-05-28
申请号：PCT/SE2014/051383
申请日：2014-11-19
CPC分类号： G08B21/18 , A61L2/24 , C12M41/48 , G01N27/3272 , G06K19/0702 , G06K19/0707 , G06K19/07745 , H04Q9/00 , H04Q2209/30 , H04Q2209/47
摘要： Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioprocessing platform including the component.
摘要翻译： 公开和描述了在生物处理环境中监测组件状态的方法，系统和装置。 某些实例提供了用于一次性生物处理组件的传感器装置。 示例性传感器设备包括附接到部件的第一部分，第一部分被配置为提供与部件相关联的标识符。 示例性传感器设备还包括被配置为基于组件的状态提供状态指示的第二部分。 示例性传感器设备被配置为将标识符和状态指示传送到与包括该组件的生物处理平台相关联的控制计算机。
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公开(公告)号：WO2015069176A1
公开(公告)日：2015-05-14
申请号：PCT/SE2014/051307
申请日：2014-11-05
发明人： GEBAUER, Klaus
IPC分类号： A61M39/18
CPC分类号： A61M39/1055 , A61M39/10 , A61M39/16 , A61M39/165 , A61M39/18 , A61M2039/1027 , C12M37/04 , F16L2201/44
摘要： The invention discloses a connector (1) for substantially aseptic connection of tubing, comprising: a) a central tubular stem member (2) with a line connection end (3) and a coupling end (5) having an annular gasket (6) arranged to engage a similar annular gasket (26) on a similar second connector (21) in sealing abutment and; b) a tubular socket member (7), concentrically arranged outside the stem member, having a flange (8) concentrically arranged outside the coupling end and comprising a cover film (9) releasably bonded to the flange and covering the coupling end of the stem member, the annular gasket and at least a portion of the flange; wherein the socket member is rotatable around the stem member and wherein the connector further comprises an annular seal member (10) in sealing abutment between an inside (11) of the socket member and an outside (12) of the stem member.
摘要翻译： 本发明公开了一种用于管道的基本上无菌连接的连接器（1），包括：a）具有线连接端（3）的中心管状杆件（2）和具有环形垫圈（6）的联接端部（5） 以在类似的第二连接器（21）上接合类似的环形垫圈（26），以在密封邻接中; b）同轴地布置在杆构件外部的管状插座构件（7），其具有同心地布置在联接端外部的凸缘（8），并且包括可剥离地接合到凸缘并覆盖杆的联接端的覆盖膜 构件，环形垫圈和凸缘的至少一部分; 其中所述插座构件可围绕所述杆构件旋转，并且其中所述连接器还包括密封邻接所述插座构件的内部（11）和所述杆构件的外部（12）之间的环形密封构件（10）。
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公开(公告)号：WO2013095268A1
公开(公告)日：2013-06-27
申请号：PCT/SE2012/051403
申请日：2012-12-17
CPC分类号： B01D63/08 , B01D63/081 , B01D63/082 , B01D2313/10 , B01D2313/105 , B01D2313/12 , B01D2313/125 , B01D2313/13 , B01D2313/21 , B01D2313/54 , B01D2317/04 , Y10T408/03
摘要： The invention discloses a distribution plate for supplying crossflow filtration cassettes, which comprises a surface, two opposite end walls, two opposite side walls, a feed channel in fluid communication with a feed inlet port and with a plurality of feed apertures; a retentate channel in fluid communication with a retentate outlet port, and with a plurality of retentate apertures; and a permeate channel in fluid communication with two permeate outlet ports and with a plurality of permeate apertures; wherein the feed channel, the retentate channel and the permeate channel extend in a direction essentially parallel with one or both side walls; wherein the feed apertures are grouped at a first area on the surface, the retentate apertures are grouped at a second area on the surface; wherein the permeate apertures are located at the first and/or the second area; and wherein a plurality of permeate connector channels extend inside the plate from at least one region of the permeate channel, adjacent thepermeate outlet ports and the permeate connector channels provide fluidic communication between the permeate apertures and the permeate channel.
摘要翻译： 本发明公开了一种用于供应交叉流过滤盒的分配板，其包括表面，两个相对的端壁，两个相对的侧壁，与进料入口端口和多个进料孔流体连通的进料通道; 与滞留物出口端口流体连通并具有多个滞留孔的滞留通道; 以及与两个渗透物出口端口和多个渗透孔口流体连通的渗透通道; 其中所述进料通道，所述滞留物通道和所述渗透通道在基本上平行于一个或两个侧壁的方向上延伸; 其中所述进料孔被分组在所述表面上的第一区域处，所述滞留孔被分组在所述表面上的第二区域; 其中所述渗透孔位于所述第一和/或所述第二区域处; 并且其中多个渗透物连接器通道从所述渗透通道的至少一个区域延伸到所述板内部，邻近所述出口端口，并且所述渗透物连接器通道提供所述渗透孔和所述渗透通道之间的流体连通。
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公开(公告)号：WO2011084101A1
公开(公告)日：2011-07-14
申请号：PCT/SE2011/050010
申请日：2011-01-10
发明人： GEBAUER, Klaus
CPC分类号： A61M39/162 , A61M39/16 , A61M39/165 , A61M39/18 , G01N30/96 , G01N2030/8881 , Y10T137/0402 , Y10T137/794
摘要： A separation or reaction unit (1; 1'; 81; 81'; 101) and a method for aseptically connecting such units. The separation or reaction unit (1; 1'; 81; 81'; 101) comprises at least one fluid inlet (3a, 3b, 5a, 5b; 3a', 3b', 5a', 5b'; 85a, 85b; 103a, 103b) and at least one fluid outlet (3a, 3b, 5a, 5b; 3a', 3b', 5a', 5b'; 85a, 85b; 103a, 103b). At least one of the inlet or outlet is sealed by at least one film (7, 9; 11; 87a, 87b; 107a, 107b) and the contact surface between the film and the separation or reaction unit is aseptic. The films are adapted to be mated with a corresponding film on another separation or reaction unit or on a fluid distribution unit (20; 57; 61) which the separation or reaction unit possibly should be connected with and said mated films are adapted to be pulled out together two and two after mating such that corresponding fluid inlets/outlets on the two connected units are mated aseptically.
摘要翻译： 分离或反应单元（1; 1'; 81; 81'; 101）和用于无菌连接这些单元的方法。 分离或反应单元（1; 1'; 81; 81'; 101）包括至少一个流体入口（3a，3b，5a，5b; 3a'，3b'，5a'，5b'; 85a，85b; 103a ，103b）和至少一个流体出口（3a，3b，5a，5b; 3a'，3b'，5a'，5b'; 85a，85b; 103a，103b）。 入口或出口中的至少一个由至少一个膜（7,9; 11; 87a，87b; 107a，107b）密封，膜和分离或反应单元之间的接触表面是无菌的。 这些膜适于与另一个分离或反应单元上的相应的膜或在分离或反应单元可能连接的流体分配单元（20; 57; 61）上配合，并且所述配合膜适于被拉动 在两个连接的单元之间相应的流体入口/出口被配合在一起，在配合之后一起排出两个和两个。
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公开(公告)号：WO2011078773A1
公开(公告)日：2011-06-30
申请号：PCT/SE2010/051425
申请日：2010-12-20
发明人： GEBAUER, Klaus , LINDSKOG, Eva , MAGNUSSON, Lars
CPC分类号： C12M23/14 , C12M27/16 , C12M41/12 , C12M41/18 , C12M41/26 , C12M41/34 , C12M41/36 , C12M41/48
摘要： A method for controlling at least one culture parameter in a bioreactor bag (1; 31a, 31b) provided in a bioreactor system, said method comprising the steps of: -providing bioreactor information to a control unit (5; 35) controlling the bioreactor system; -controlling the at least one culture parameter in dependence of the bioreactor information.
摘要翻译： 一种用于在生物反应器系统中提供的生物反应器袋（1; 31a，31b）中控制至少一种培养参数的方法，所述方法包括以下步骤： - 将生物反应器信息提供给控制单元（5; 35），以控制生物反应器系统 ; - 根据生物反应器信息控制至少一种培养参数。
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公开(公告)号：WO2010138061A1
公开(公告)日：2010-12-02
申请号：PCT/SE2010/050559
申请日：2010-05-24
发明人： GEBAUER, Klaus , KRANSE, Jan , LUNDKVIST, Mats
CPC分类号： G01N30/6017 , B33Y30/00 , B33Y80/00 , Y10T29/494 , Y10T137/87265
摘要： A fluid distributor unit comprising a channel system where one or more inlet channels (2) starting on an inlet side (3) of the distributor unit branch out successively into several channels (6) ending on the other side of the distributor unit, called the outlet side (4), characterised in that said distributor unit is provided in one single body (1) by free form fabrication.
摘要翻译： 流体分配器单元，其包括通道系统，其中从分配器单元的入口侧（3）开始的一个或多个入口通道（2）连续分支到在分配器单元的另一侧终止的多个通道（6），称为 出口侧（4），其特征在于，所述分配器单元通过自由形式制造设置在一个单体（1）中。
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公开(公告)号：WO2008009412A1
公开(公告)日：2008-01-24
申请号：PCT/EP2007/006320
申请日：2007-07-17
CPC分类号： G01N30/6004 , B01D15/14 , B01D15/22 , G01N30/6017 , G01N30/603
摘要： The present invention relates to axial flow chromatography columns and methods for separating one or more analytes in a liquid by the use of such columns. The column comprises a first port for mobile phase and a transverse fluid distribution channel for distributing fluid uniformly throughout the packed bed. The first port comprises an inlet and an outlet having a passageway therebetween, the outlet having an asymmetric configuration relative to the fluid distribution channel.
摘要翻译： 本发明涉及轴流式色谱柱和通过使用这种色谱柱分离液体中一种或多种分析物的方法。 该柱包括用于流动相的第一端口和横向流体分配通道，用于将流体均匀地分布在整个填充床中。 第一端口包括入口和出口，其间具有通道，出口具有相对于流体分配通道的非对称构型。
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