公开(公告)号：WO2013049431A3

公开(公告)日：2013-06-27

申请号：PCT/US2012057683

申请日：2012-09-28

Applicant: GE HEALTHCARE LTD ,  MEDI PHYSICS INC

Inventor： JACKSON ALEXANDER

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J19/0093 ,  B01J2219/00792 ,  B01J2219/00799 ,  B01J2219/00813 ,  B01J2219/00844 ,  B01J2219/00867 ,  B01J2219/00876 ,  B01J2219/00894 ,  C07C247/08

Abstract: A stacked reactor vessel (10) provides two separate reaction vessel compartments (12, 14) for performing chemical reactions and is particularly suited to multi-step chemical reactions and for incorporation into a cassette (110) for automated operation.

Abstract translation: 堆叠的反应器容器（10）提供用于进行化学反应的两个单独的反应容器隔室（12,14），并且特别适用于多步化学反应并且用于结合到盒（110）中用于自动操作。

公开(公告)号：WO2013144301A3

公开(公告)日：2013-11-21

申请号：PCT/EP2013056720

申请日：2013-03-28

Applicant: GE HEALTHCARE LTD

Inventor： BHALLA RAJIV ,  JACKSON ALEXANDER ,  SMITH GARETH

IPC: A61K51/04 ,  A61K51/12 ,  C07B59/00

CPC classification number: A61K51/0497 ,  A61K51/1282 ,  C07B59/001

Abstract: The present invention relates to an improved [18F] labelled synthon composition, wherein the non-radioactive impurities in said composition have been found to be more straightforward to remove than with known compositions comprising said [18F] labelled synthon. The resultant purified [18F] label led synthon therefore can be used in the production of a positron emission tomography (PET) tracer having improved properties for in vivo imaging. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.

Abstract translation: 本发明涉及一种改进的[18 F]标记的合成子组合物，其中已发现所述组合物中的非放射性杂质比包含所述[18 F]标记的合成子的已知组合物更直接去除。 因此，所得纯化的[18F]标签引导合成子可用于生产具有改进的体内成像性质的正电子发射断层扫描（PET）示踪剂。 本发明还包括使用所述放射性药物组合物进行成像和/或诊断的方法。

公开(公告)号：WO2009083530A2

公开(公告)日：2009-07-09

申请号：PCT/EP2008068155

申请日：2008-12-22

Applicant: GE HEALTHCARE LTD ,  JACKSON ALEXANDER ,  BHALLA RAJIV

Inventor： JACKSON ALEXANDER ,  BHALLA RAJIV

IPC: C01B9/00 ,  C07D487/08

CPC classification number: C07D487/08 ,  B01J19/0093 ,  B01J2219/00781 ,  C01B9/08 ,  C07B59/002

Abstract: The invention relates to methods for processing [18F]-fluoride target water using a solid-support bound Cryptand of formula (I) and to apparatus for performing such methods. The resultant [18F]-fluoride is useful for preparation of radiopharmaceuticals by nucleophilic fluorination, specifically for use in Positron Emission Tomography (PET).

Abstract translation: 本发明涉及使用式（I）的固体 - 载体结合穴状配体处理[18 F] - 氟化物目标水的方法以及用于执行这种方法的装置。 所得[18 F] - 氟化物可用于亲核氟化制备放射性药物，特别用于正电子发射断层扫描（PET）。

公开(公告)号：WO2008155339A3

公开(公告)日：2009-02-26

申请号：PCT/EP2008057659

申请日：2008-06-18

Applicant: GE HEALTHCARE LTD ,  JACKSON ALEXANDER ,  BHALLA RAJIV

Inventor： JACKSON ALEXANDER ,  BHALLA RAJIV

IPC: C07D487/08 ,  C07B59/00

CPC classification number: C07B59/008 ,  C07D487/08 ,  C07D487/22

Abstract: The invention provides a method for radiofluorination of biological vectors such as peptides comprising reaction of a compound of formula (II): or a salt thereof with a source of [18F]-fluoride, to give a compound of formula (I): or a salt thereof. The method may be effected under mild reaction conditions and offers a more chemoselective labelling approach Novel reagents for use in the radiofluoridation method, and uses of the resultant 18F-labelled vectors are also provided

Abstract translation: 本发明提供了生物载体例如肽的放射性氟化方法，其包括式（II）化合物或其盐与[18 F] - 氟化物源的反应，得到式（I）化合物：或 的盐。 该方法可以在温和的反应条件下进行，并提供更多的化学选择性标记方法。还提供了用于放射性氟化方法的新型试剂，以及所得18F标记载体的用途

公开(公告)号：WO2006032911A3

公开(公告)日：2006-08-03

申请号：PCT/GB2005003679

申请日：2005-09-23

Applicant: GE HEALTHCARE LTD ,  SOLBAKKEN MAGNE ,  CUTHBERTSON ALAN ,  STOREY ANTHONY EAMON ,  JACKSON ALEXANDER ,  RICKETTS SALLY-ANN ,  IVESON PETER BRIAN

Inventor： SOLBAKKEN MAGNE ,  CUTHBERTSON ALAN ,  STOREY ANTHONY EAMON ,  JACKSON ALEXANDER ,  RICKETTS SALLY-ANN ,  IVESON PETER BRIAN

IPC: A61K51/04 ,  A61K49/08

CPC classification number: A61K49/10 ,  A61K49/085 ,  A61K51/0497

Abstract: The present invention discloses that imaging agents which comprise a specific type of matrix metalloproteinase inhibitors (MMPi's) of the hydroxamate class labelled with an imaging moiety, are useful diagnostic imaging agents for in vivo imaging and diagnosis of the mammalian body.

Abstract translation: 本发明公开了包含用成像部分标记的异羟肟酸酯类型的特定类型的基质金属蛋白酶抑制剂（MMPi）的成像剂是用于哺乳动物身体的体内成像和诊断的有用的诊断显像剂。