公开(公告)号：WO2013144301A3

公开(公告)日：2013-11-21

申请号：PCT/EP2013056720

申请日：2013-03-28

Applicant: GE HEALTHCARE LTD

Inventor： BHALLA RAJIV ,  JACKSON ALEXANDER ,  SMITH GARETH

IPC: A61K51/04 ,  A61K51/12 ,  C07B59/00

CPC classification number: A61K51/0497 ,  A61K51/1282 ,  C07B59/001

Abstract: The present invention relates to an improved [18F] labelled synthon composition, wherein the non-radioactive impurities in said composition have been found to be more straightforward to remove than with known compositions comprising said [18F] labelled synthon. The resultant purified [18F] label led synthon therefore can be used in the production of a positron emission tomography (PET) tracer having improved properties for in vivo imaging. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.

Abstract translation: 本发明涉及一种改进的[18 F]标记的合成子组合物，其中已发现所述组合物中的非放射性杂质比包含所述[18 F]标记的合成子的已知组合物更直接去除。 因此，所得纯化的[18F]标签引导合成子可用于生产具有改进的体内成像性质的正电子发射断层扫描（PET）示踪剂。 本发明还包括使用所述放射性药物组合物进行成像和/或诊断的方法。