公开(公告)号：WO2022240682A1

公开(公告)日：2022-11-17

申请号：PCT/US2022/028096

申请日：2022-05-06

Applicant: GENERAL ELECTRIC COMPANY

Inventor： SHOUDY, David Andrew ,  GALLIGAN, Craig Patrick ,  GRIFFIN, Weston Blaine ,  ASHE, Jeffrey Michael ,  LEE, Warren ,  SABATINI, James Enrico

IPC: A61N7/00 ,  A61B8/00 ,  A61B2090/064 ,  A61B2090/378 ,  A61B8/08 ,  A61B8/4227 ,  A61B8/4254 ,  A61B8/4427 ,  A61B8/4477 ,  A61N2007/0026 ,  A61N2007/0052 ,  A61N2007/0078 ,  A61N7/02

Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam (206) to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure (100, 200) to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure (100, 200) is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure (100, 200) provides repeatable targeting of the target anatomic region, even when in non-clinical settings.

公开(公告)号：WO2015013598A1

公开(公告)日：2015-01-29

申请号：PCT/US2014/048169

申请日：2014-07-25

Applicant: GENERAL ELECTRIC COMPANY

Inventor： PULEO, Christopher Michael ,  NELSON, John Richard ,  SPOONER, Patrick McCoy ,  LENIGK, Ralf ,  WOOD, Nichole Lea ,  ZHU, Li ,  GALLIGAN, Craig Patrick

IPC: G01N27/327 ,  G01N27/447 ,  H01G11/48

CPC classification number: B01D57/02 ,  G01N27/4473

Abstract: A device and a system for eluting biomolecules from biological sample by electroelution are provided. The device for electroelution of biomolecules from a biological sample is constituted with a housing configured to receive an electrolyte and the biological sample, at least two electrodes comprising conductive redox polymers operationally coupled to the housing, and a biomolecule impermeable layer disposed on at least one of the electrodes. The biomolecule impermeable layer disposed on at least one of the electrodes to prevent the biomolecules from reaching the electrode. A system is provided, wherein the system comprises a sample collection port, one or more reservoirs comprising a buffer, a solvent, a reagent or combinations thereof, an device for electroelution, and a controller.

Abstract translation: 提供了一种通过电洗脱从生物样品中洗脱生物分子的装置和系统。 用于从生物样品电洗脱生物分子的装置由构造成接收电解质和生物样品的壳体构成，至少两个电极包括可操作地耦合到壳体的导电氧化还原聚合物，以及生物分子不可渗透层，其设置在至少一个 电极。 生物分子不渗透层设置在至少一个电极上以防止生物分子到达电极。 提供了一种系统，其中系统包括样品采集端口，一个或多个包含缓冲液，溶剂，试剂或其组合的储存器，用于电洗脱的装置和控制器。