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公开(公告)号：WO2021050390A1
公开(公告)日：2021-03-18
申请号：PCT/US2020/049482
申请日：2020-09-04
Applicant: GENERAL ELECTRIC COMPANY
Inventor： SINGANAMALLI, Asha , SHOUDY, David Andrew , ASHE, Jeffrey Michael , PULEO, Christopher Michael
Abstract: Embodiments of the present disclosure relate to techniques for neuromodulation delivery. Based on image data acquired from the subject, control parameters controlling energy application of neuromodulating energy may be dynamically changed during the course of the delivery to maintain desired characteristics of the neuromodulating energy. For example, the beam of the neuromodulating energy may be dynamically adjusted to account for movement of an organ during breathing. In another embodiment, a desired region of interest is identified within the subject based on a trained neural network and the acquired image data.
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公开(公告)号：WO2019173525A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/021027
申请日：2019-03-06
Applicant: GENERAL ELECTRIC COMPANY
Inventor： PULEO, Christopher Michael , COTERO, Victoria Eugenia
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue to cause altered activity at a synapse between a neuron and a non-neuronal cell. In one embodiment, the energy is applied to cause persistent effects as a result of repeated application of energy within a predefined treatment window.
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公开(公告)号：WO2019173518A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/021018
申请日：2019-03-06
Applicant: GENERAL ELECTRIC COMPANY
Inventor： PULEO, Christopher Michael , COTERO, Victoria Eugenia
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue (e.g., an organ) that include applying energy (e.g., ultrasound energy) into the tissue to cause altered activity at a synapse between a neuron and a non-neuronal cell. In one embodiment, the energy is applied to cause competing or opposing effects for bi-directional control of physiological processes.
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4.发明申请METHOD AND DEVICE FOR COLLECTION AND AMPLIFICATION OF CIRCULATING NUCLEIC ACIDS 审中-公开用于收集和放大循环核酸的方法和装置
公开(公告)号：WO2015013486A1
公开(公告)日：2015-01-29
申请号：PCT/US2014/047953
申请日：2014-07-24
Applicant: GENERAL ELECTRIC COMPANY
Inventor： KVAM, Erik Leeming , NELSON, John Richard , GROSSMANN, Gregory Andrew , HELLER, Ryan Charles , FINEHOUT, Erin Jean , PULEO, Christopher Michael , WATERS, William Patrick
CPC classification number: C12N15/1017 , B01L7/52 , B01L2300/0681 , C12Q1/68 , C12Q1/6844 , C12Q1/6806 , C12Q2521/501 , C12Q2531/125
Abstract: Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-celluar fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a bilogical sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.
Abstract translation: 本文提供了从生物样品的非细胞级分收集和扩增循环核酸的方法。 从非细胞级分提取循环核酸，并进行环化以产生单链核酸环，随后通过使用随机引物的滚动循环扩增产生扩增文库。 还提供了用于从生物样品中收集非细胞部分的装置。 该装置包括与过滤膜直接接触的过滤膜和干燥固体基质。
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5.发明申请
公开(公告)号：WO2014035547A2
公开(公告)日：2014-03-06
申请号：PCT/US2013/048853
申请日：2013-07-01
Applicant: GENERAL ELECTRIC COMPANY
Inventor： NELSON, John Richard , ZHU, Li , FINEHOUT, Erin Jean , CHEN, Xiaohui , SHAIKH, Kashan Ali , PULEO, Christopher Michael , SPOONER, Patrick McCoy
IPC: C07H21/00
CPC classification number: C12N15/1017
Abstract: A method of isolating nucleic acids from a biological material, comprises applying the biological material on a substrate comprising one or more cell lysis reagents impregnated therein; applying a fluid to the biological material applied on the substrate; extracting the nucleic acids from the biological material applied on the substrate; and collecting the extracted nucleic acids in a substantially intact form, wherein the collected nucleic acid has a molecular weight greater than or equal to 20 kb.
Abstract translation: 从生物材料中分离核酸的方法包括将生物材料应用于包含其中浸渍的一种或多种细胞裂解试剂的底物; 将液体施加到施加在基底上的生物材料; 从施加在基底上的生物材料中提取核酸; 并以基本上完整的形式收集所提取的核酸，其中所收集的核酸具有大于或等于20kb的分子量。
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Patent Agency Ranking6.发明申请DEVICES AND SYSTEMS FOR ISOLATING BIOMOLECULES AND ASSOCIATED METHODS THEREOF 审中-公开用于分离生物分子的装置和系统及其相关方法
公开(公告)号：WO2014022459A1
公开(公告)日：2014-02-06
申请号：PCT/US2013/052825
申请日：2013-07-31
Applicant: GENERAL ELECTRIC COMPANY
Inventor： PULEO, Christopher Michael , LENIGK, Ralf , NELSON, John Richard , CHEN, Xiaohui , ZHU, Li , FINEHOUT, Erin Jean , SPOONER, Patrick McCoy
IPC: C12Q1/68
CPC classification number: C12N15/101 , B01L3/50273 , B01L3/502738 , B01L2200/0631 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2400/0418 , B01L2400/0487 , B01L2400/0683
Abstract: A device, a system, a cartridge and a method for isolating biomolecules from biological materials are provided. The device comprises a substrate; a reagent storage location; and a self-rupturing component comprising a fluid and a pressure source embedded therein, wherein the substrate, the reagent storage location and the self-rupturing component are operationally coupled to each other. A system is provided, wherein the system comprises an extraction matrix, an enclosed matrix housing comprising a biological sample inlet, one or more biomolecule extraction reagents to extract biomolecules and at least one pressure source embedded therein, a fluidic extraction circuit; and a controller for activating the embedded pressure source. A method of isolating nucleic acids from biological materials is also provided.
Abstract translation: 提供了一种用于从生物材料中分离生物分子的装置，系统，盒和方法。 该装置包括基板; 试剂储存位置; 以及包含嵌入其中的流体和压力源的自破裂部件，其中所述基板，所述试剂储存位置和所述自破裂部件在操作上彼此耦合。 提供了一种系统，其中所述系统包括提取矩阵，包括生物样品入口的封闭矩阵壳体，用于提取生物分子的一种或多种生物分子提取试剂和嵌入其中的至少一种压力源，流体萃取回路; 以及用于启动嵌入式压力源的控制器。 还提供了从生物材料中分离核酸的方法。
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公开(公告)号：WO2023009782A1
公开(公告)日：2023-02-02
申请号：PCT/US2022/038792
申请日：2022-07-29
Inventor： PULEO, Christopher Michael , KVAM, Erik Leeming , WONG, Pak Kin , TORAB, Peter , SURRETTE, Christine Lynne
Abstract: The subject matter of the present disclosure generally relates to techniques for isolating bacterial cells from a biological sample comprising red blood cells. Using an aggregating agent and an anticoagulant during sedimentation permits separation of bacterial pathogens in the sample from red blood cells. The separated sedimentation layer, which is enriched in any bacterial pathogens, can be centrifuged and resuspended to concentrate the bacteria for additional analysis, such as bacterial identification and/or antibiotic susceptibility tests.
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公开(公告)号：WO2022169712A1
公开(公告)日：2022-08-11
申请号：PCT/US2022/014585
申请日：2022-01-31
Applicant: GENERAL ELECTRIC COMPANY
Abstract: Combined neuromodulation techniques are disclosed to treat metabolic disorders. The combined neuromodulation techniques may include dual-site neuromodulation or single-site neuromodulation. In embodiments, the neuromodulation may be administered as a combined therapy with a pharmaceutical treatment. In one embodiment, the techniques may include applying ultrasound energy to a region of interest of a subject having a metabolic disorder to cause an autonomic signaling response in the subject.
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公开(公告)号：WO2021118783A1
公开(公告)日：2021-06-17
申请号：PCT/US2020/061327
申请日：2020-11-19
Applicant: GENERAL ELECTRIC COMPANY
Inventor： GRAF, John Frederick , PULEO, Christopher Michael , ASHE, Jeffrey Michael , COTERO, Victoria Eugenia , SHOUDY, David Andrew
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.
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公开(公告)号：WO2015013598A1
公开(公告)日：2015-01-29
申请号：PCT/US2014/048169
申请日：2014-07-25
Applicant: GENERAL ELECTRIC COMPANY
Inventor： PULEO, Christopher Michael , NELSON, John Richard , SPOONER, Patrick McCoy , LENIGK, Ralf , WOOD, Nichole Lea , ZHU, Li , GALLIGAN, Craig Patrick
IPC: G01N27/327 , G01N27/447 , H01G11/48
CPC classification number: B01D57/02 , G01N27/4473
Abstract: A device and a system for eluting biomolecules from biological sample by electroelution are provided. The device for electroelution of biomolecules from a biological sample is constituted with a housing configured to receive an electrolyte and the biological sample, at least two electrodes comprising conductive redox polymers operationally coupled to the housing, and a biomolecule impermeable layer disposed on at least one of the electrodes. The biomolecule impermeable layer disposed on at least one of the electrodes to prevent the biomolecules from reaching the electrode. A system is provided, wherein the system comprises a sample collection port, one or more reservoirs comprising a buffer, a solvent, a reagent or combinations thereof, an device for electroelution, and a controller.
Abstract translation: 提供了一种通过电洗脱从生物样品中洗脱生物分子的装置和系统。 用于从生物样品电洗脱生物分子的装置由构造成接收电解质和生物样品的壳体构成，至少两个电极包括可操作地耦合到壳体的导电氧化还原聚合物，以及生物分子不可渗透层，其设置在至少一个 电极。 生物分子不渗透层设置在至少一个电极上以防止生物分子到达电极。 提供了一种系统，其中系统包括样品采集端口，一个或多个包含缓冲液，溶剂，试剂或其组合的储存器，用于电洗脱的装置和控制器。
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