公开(公告)号：WO2017184192A1

公开(公告)日：2017-10-26

申请号：PCT/US2016/047372

申请日：2016-08-17

Applicant: GENERAL ELECTRIC COMPANY

Inventor： LANG, Philipp ,  SALVAMOSER, Ruben Julian ,  SAMPER, Victor Donald ,  RENSCH, Christian Friedrich Peter

IPC: G01F11/28 ,  B67D7/02 ,  G01F13/00

CPC classification number: B01J19/24 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00792 ,  B01J2219/00795 ,  B01J2219/00858 ,  B01J2219/00891 ,  B01J2219/009 ,  B01J2219/00963 ,  B67D7/0266 ,  G01F11/28 ,  G01F13/00

Abstract: Fluid transport approaches are described that operate without the need for precise displacement of an actuator and with little or no sensing in the flow path. In certain implementations, a gas phase in a fluid reservoir is compressed by a pressure source such that releasing the pressure, such as by opening a valve to an intermediary conduit, displaces fluid to the intermediary chamber. Closing that fluid path and opening a different fluid path to a chamber at ambient temperature causes the fluid to be displaced to the chamber.

Abstract translation: 描述了流体输送方法，其不需要致动器的精确位移以及流动路径中的很少感测或不需要感测。 在某些实施方式中，流体储存器中的气相被压力源压缩，使得释放压力（例如通过打开阀到中间导管）将流体排出到中间腔室。 在环境温度下关闭流体路径并打开到腔室的不同流体路径导致流体移动到腔室。

公开(公告)号：WO2018052768A1

公开(公告)日：2018-03-22

申请号：PCT/US2017/050166

申请日：2017-09-06

Applicant: GENERAL ELECTRIC COMPANY

Inventor： RENSCH, Christian Friedrich Peter ,  SAMPER, Victor Donald ,  SALVAMOSER, Ruben Julian

IPC: B01L3/00 ,  B01L9/00 ,  F16K99/00

Abstract: Described herein is a system for on-demand synthesis / analysis of compounds and/or diagnostic applications. In general, any application that requires a low-cost binary switch valve array for fast (

Abstract translation: 这里描述的是用于按需合成/分析化合物和/或诊断应用的系统。 通常，需要低成本二元开关阀阵列以空间紧凑的格式进行气体或液体的快速（<100ms）切换的任何应用与本文所述的系统兼容。

公开(公告)号：WO2014066748A1

公开(公告)日：2014-05-01

申请号：PCT/US2013/066792

申请日：2013-10-25

Applicant: GENERAL ELECTRIC COMPANY

Inventor： RENSCH, Christian Friedrich Peter ,  SAMPER, Victor Donald ,  BOELD, Christoph ,  SALVAMOSER, Ruben Julian

IPC: C12M1/00 ,  B01L3/00 ,  C12P19/34

CPC classification number: B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0631 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/12 ,  G01N27/44791 ,  G01N30/6095 ,  Y10T29/49826 ,  Y10T156/10

Abstract: Techniques and devices are provided related to insert assemblies that may be used in conjunction with microfluidic devices. In one embodiment, the insert assemblies include a functional material, such as a solid stationary phase, that may be coupled to a microfluidic pathway via the insert assembly. In this manner, solid stationary phase materials that may be challenging to directly apply to a microfluidic device may be separately enclosed inside the insert element prior to assembly into a microfluidic device, such as a microfluidic chip.

Abstract translation: 提供了与可与微流体装置结合使用的插入组件相关的技术和装置。 在一个实施例中，插入组件包括可经由插入组件耦合到微流体通路的功能材料，例如固体固定相。 以这种方式，在组装成微流体装置（例如微流体芯片）之前，可能难以直接应用于微流体装置的固体固相材料可以单独包封在插入元件内部。

公开(公告)号：WO2013003528A1

公开(公告)日：2013-01-03

申请号：PCT/US2012/044523

申请日：2012-06-28

Applicant: GENERAL ELECTRIC COMPANY ,  RENSCH, Christian Friedrich Peter ,  BALLER, Marko Klaus ,  BOELD, Christoph ,  SAMPER, Victor Donald ,  ULIN, Johan Urban Ingemar

Inventor： RENSCH, Christian Friedrich Peter ,  BALLER, Marko Klaus ,  BOELD, Christoph ,  SAMPER, Victor Donald ,  ULIN, Johan Urban Ingemar

IPC: C07B59/00 ,  B01J19/00

CPC classification number: C07B59/00 ,  B01J19/0093 ,  B01J2219/00889 ,  B01J2219/00959

Abstract: Disclosed are microfluidic devices and kits for containing radioisotopes. The devices and kits comprises at least one confining geometry having a cross-section dimension below the beta(+) or beta(-) range of a radioisotope, when containing the radioisotope configured in such a way that neighboring segments of the confining geometries are isolated from its nearest neighbor such that no measurable kinetic positron energy transfer occurs between the segments when containing the radioisotope. Methods of storage and synthesis of radiopharmaceuticals are also disclosed. In another aspect, the present invention relates to methods of storing radiotracers and synthesizing radiopharmaceuticals, using the aforementioned device. The radiotracers and radiopharmaceuticals comprises 18 F, 11 C, 14 C, 99m Tc, 123 I, 125 I, 131 I, 68 Ga, 67 Ga, 15 O, 13 N, 82R b, 62 Cu, 32 P, 89 Sr, 153 Sm, 186 Re, 201 Tl, 111 In, or combinations thereof.

Abstract translation: 公开了用于含有放射性同位素的微流体装置和试剂盒。 所述装置和试剂盒包含至少一个具有低于放射性同位素的β（+）或β（ - ）范围的横截面尺寸的限制几何形状，当包含以这样的方式构造的放射性同位素时，限制几何形状的相邻段被隔离 从其最近的邻居，使得当包含放射性同位素时，在段之间不发生可测量的动能正电子能量转移。 还公开了放射性药物的储存和合成方法。 另一方面，本发明涉及使用上述装置储存放射性示踪剂并合成放射性药物的方法。 放射性示踪剂和放射性药物包括18F，11C，14C，99mTc，123I，125I，131I，68Ga，67Ga，150C，13N，82Rb，62Cu，32P，89Sr，153Sm，186Re，201T1,1111In或其组合。