公开(公告)号：WO2023060362A1

公开(公告)日：2023-04-20

申请号：PCT/CA2022/051520

申请日：2022-10-14

申请人： GENETOLEAD INC.

发明人： FARMER, Luc ,  LAPLANTE, Steven ,  AYOTTE, Yann ,  LARDA, Sacha Thierry ,  ALAPOUR, Saba ,  WOO, Simon ,  BENDAHAN, David ,  DENK, Maria ,  FARAHANI, Majid ,  IDDIR, Mustapha

IPC分类号： C07D209/18 ,  A61K31/404 ,  A61K31/405 ,  A61K31/454 ,  A61K31/496 ,  A61K31/506 ,  A61K31/4045 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/5386 ,  C07D209/14 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/06 ,  C07D491/107

摘要： There is provided a compound of formula (I), and its use for inhibiting RAS (wild type or mutant), for example HRAS, NRAS, and/or KRAS, and for the prevention or treatment of a disease or disorder associated with abnormal RAS activity, for example abnormal RAS activity caused by a mutation in RAS, including cancers with a mutated RAS. (I)