公开(公告)号：WO2020252151A1

公开(公告)日：2020-12-17

申请号：PCT/US2020/037214

申请日：2020-06-11

Applicant: GILEAD SCIENCES, INC.

Inventor： CANALES, Eda Y. ,  DESAI, Manoj C. ,  GORMAN, Eric ,  LI, Jiayao ,  SAITO, Roland D. ,  TAYLOR, James G. ,  WRIGHT, Nathan E.

IPC: A61P3/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D401/14

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) of generic Formula (I) and methods of use and manufacture thereof.

公开(公告)号：WO2015006733A1

公开(公告)日：2015-01-15

申请号：PCT/US2014/046415

申请日：2014-07-11

Applicant: GILEAD SCIENCES, INC. ,  JI, Mingzhe ,  MARTIN, Teresa Alejandra Trejo

Inventor： JI, Mingzhe ,  MARTIN, Teresa Alejandra Trejo ,  DESAI, Manoj C. ,  JIN, Haolun ,  PYUN, Hyung-Jung

IPC: C07D471/14 ,  A61K31/4995 ,  A61P31/18

CPC classification number: A61K31/4985 ,  C07D471/14 ,  C07D471/18

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R 1 , R 5 , W, X, Y 1 , Y 2 , and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。 该化合物具有下式（I）：（I），其包括立体异构体及其药学上可接受的盐，其中L，R 1，R 5，W，X，Y 1，Y 2和Z如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。