公开(公告)号：WO2020264081A1

公开(公告)日：2020-12-30

申请号：PCT/US2020/039501

申请日：2020-06-25

Applicant: GILEAD SCIENCES, INC.

Inventor： AKTOUDIANAKIS, Evangelos ,  AMBROSI, Andrea ,  ASSELIN, Sylvie M. ,  BACHRACH, Florence J. ,  BADALOV, Pavel R. ,  CHIN, Gregory F. ,  LATHROP, Stephen P. ,  LEW, Willard ,  MACKMAN, Richard L. ,  MERIT, Jeffrey E. ,  METOBO, Samuel E. ,  MISH, Michael R. ,  PRITCHETT, Beau P. ,  PYUN, Hyung-Jung ,  REGENS, Christopher S. ,  VIEIRA, Tiago ,  WANG, Xianghong ,  WEINSTEIN, Adam B. ,  WENDERSKI, Todd A. ,  ZHENG, Zehua

IPC: C07D471/04 ,  C07D413/04 ,  C07D213/81

Abstract: The present disclosure provides methods for preparing (7?)-2-((2-amino-7- fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-l-ol or a salt thereof and related key intermediates.

公开(公告)号：WO2016106384A1

公开(公告)日：2016-06-30

申请号：PCT/US2015/067511

申请日：2015-12-22

Applicant: GILEAD SCIENCES, INC.

Inventor： BROWN, Brandon Heath ,  CHAN, Brenda J. Burke ,  CHIU, Anna ,  GRIGGS, Nolan ,  HEUMANN, Lars V. ,  LATHROP, Stephen P. ,  REYNOLDS, Troy Evan ,  SARMA, Keshab ,  SILER, David Allen ,  THOMPSON, Andrew S. ,  WANG, Tao

IPC: C07D401/14 ,  C07D233/56

CPC classification number: C07D233/64 ,  C07B2200/13 ,  C07D233/56 ,  C07D401/14

Abstract: The present disclosure provides processes for the preparation of a compound of formula (A) which exhibits apoptosis signal-regulating kinase ("ASK1") inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.

Abstract translation: 本公开内容提供了制备具有凋亡信号调节激酶（“ASK1”）抑制活性的式（A）化合物的方法，因此可用于治疗诸如肾病，糖尿病肾病和肾纤维化的疾病。 本公开还提供了作为合成中间体的化合物。