公开(公告)号：WO2019161017A1

公开(公告)日：2019-08-22

申请号：PCT/US2019/017948

申请日：2019-02-14

申请人： GILEAD SCIENCES, INC.

发明人： BRIZGYS, Gediminas ,  CANALES, Eda ,  CHOU, Chienhung ,  GRAUPE, Michael ,  SAITO, Roland D. ,  SCHROEDER, Scott D. ,  TSE, Winston C. ,  WU, Qiaoyin ,  ZHANG, Jennifer R. ,  LI, Jiayao

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  A61P31/18 ,  A61K31/4439

摘要： The invention provides compounds having Formula (I): (I) or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

公开(公告)号：WO2018144605A1

公开(公告)日：2018-08-09

申请号：PCT/US2018/016243

申请日：2018-01-31

申请人： GILEAD SCIENCES, INC.

发明人： AKTOUDIANAKIS, Evangelos ,  CANALES, Eda ,  CURRIE, Kevin S. ,  KATO, Darryl ,  LI, Jiayao ,  LINK, John O. ,  METOBO, Samuel E. ,  SAITO, Roland D. ,  SCHROEDER, Scott D. ,  SHAPIRO, Nathan ,  TSE, Winston C. ,  WU, Qiaoyin

IPC分类号： C07D471/14 ,  C07D491/22 ,  C07D498/14 ,  C07D519/00 ,  A61K31/5025 ,  A61K31/503 ,  A61P31/12

摘要： The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.

公开(公告)号：WO2011156610A2

公开(公告)日：2011-12-15

申请号：PCT/US2011/039813

申请日：2011-06-09

申请人： GILEAD SCIENCES, INC. ,  CAI, Zhenhong, R. ,  DU, Zhimin ,  JI, Mingzhe ,  JIN, Haolun ,  KIM, Choung, U. ,  MISH, Michael, R. ,  PHILLIPS, Barton, W. ,  PYUN, Hyung-jung ,  SHENG, Xiaoning, C. ,  WU, Qiaoyin ,  ZONTE, Catalin, Sebastian

发明人： CAI, Zhenhong, R. ,  DU, Zhimin ,  JI, Mingzhe ,  JIN, Haolun ,  KIM, Choung, U. ,  MISH, Michael, R. ,  PHILLIPS, Barton, W. ,  PYUN, Hyung-jung ,  SHENG, Xiaoning, C. ,  WU, Qiaoyin ,  ZONTE, Catalin, Sebastian

IPC分类号： C07D401/10

CPC分类号： C07D401/10 ,  A61K45/06 ,  C07D215/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D411/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07F9/65583

摘要： The present application includes novel inhibitors of HCV, compositions containing such compounds, therapeutic methods that include the administration of such compounds.

摘要翻译： 本申请包括HCV的新型抑制剂，含有这些化合物的组合物，包括施用这些化合物的治疗方法。

公开(公告)号：WO2009005676A3

公开(公告)日：2009-01-08

申请号：PCT/US2008/007927

申请日：2008-06-26

申请人： GILEAD SCIENCES, INC. ,  CHO, Aesop ,  CLARKE, Michael, O'Neil, Hanrahan ,  KIM, Choung, U. ,  LINK, John, O. ,  PYUN, Hyung-jung ,  SHENG, Xiaoning, C. ,  WU, Qiaoyin

发明人： CHO, Aesop ,  CLARKE, Michael, O'Neil, Hanrahan ,  KIM, Choung, U. ,  LINK, John, O. ,  PYUN, Hyung-jung ,  SHENG, Xiaoning, C. ,  WU, Qiaoyin

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D417/14 ,  C07D487/04 ,  A61K31/401 ,  A61K31/4025 ,  A61K31/407

摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：WO2022159387A1

公开(公告)日：2022-07-28

申请号：PCT/US2022/012773

申请日：2022-01-18

申请人： GILEAD SCIENCES, INC.

发明人： CHU, Hang ,  GONZALEZ BUENROSTRO, Ana Z. ,  GUO, Hongyan ,  HAN, Xiaochun ,  HURTLEY, Anna E. ,  JIANG, Lan ,  LI, Jiayao ,  LIN, David W. ,  MITCHELL, Michael L. ,  NADUTHAMBI, Devan ,  SCHWARZWALDER, Gregg M. ,  SZEWCZYK, Suzanne M. ,  VON BARGEN, Matthew J. ,  WU, Qiaoyin ,  YANG, Hong ,  ZHANG, Jennifer R.

IPC分类号： C07D471/18 ,  A61P31/18

摘要： The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

公开(公告)号：WO2022072520A1

公开(公告)日：2022-04-07

申请号：PCT/US2021/052683

申请日：2021-09-29

申请人： GILEAD SCIENCES, INC.

发明人： CHU, Hang ,  GUO, Hongyan ,  JIANG, Lan ,  LI, Jiayao ,  LIN, David W. ,  PYUN, Hyung-Jung ,  WU, Qiaoyin ,  YANG, Hong ,  ZAJDLIK, Adam D. ,  ZHANG, Jennifer R.

IPC分类号： C07D471/04 ,  A61P31/18 ,  A61K31/495

摘要： Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): (I) including stereoisomers and pharmaceutically acceptable salts thereof. Methods associated with the preparation and use of the disclosed compounds, as well as pharmaceutical compositions comprising such compounds are also disclosed.

公开(公告)号：WO2020197991A1

公开(公告)日：2020-10-01

申请号：PCT/US2020/023819

申请日：2020-03-20

申请人： GILEAD SCIENCES, INC.

发明人： CHU, Hang ,  GONZALEZ BUENROSTRO, Ana Z. ,  GUO, Hongyan ,  HAN, Xiaochun ,  JIANG, Lan ,  LI, Jiayao ,  MITCHELL, Michael L. ,  PYUN, Hyung-Jung ,  SCHROEDER, Scott D. ,  SCHWARZWALDER, Gregg M. ,  SHAPIRO, Nathan D. ,  SHIVAKUMAR, Devleena M. ,  WU, Qiaoyin ,  YANG, Hong ,  ZHANG, Jennifer R.

IPC分类号： A61P31/18 ,  C07D471/04 ,  C07D491/06 ,  A61K31/4375

摘要： Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , L, W 1 , W 2 , X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.