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56 条记录 (耗时 0.029 秒)

    TRIAZOLOPYRIDAZINES AS PROTEIN KINASES INHIBITORS
    7.
    发明申请
    TRIAZOLOPYRIDAZINES AS PROTEIN KINASES INHIBITORS 审中-公开
    作为蛋白激酶抑制剂的三唑吡啶

    公开(公告)号：WO2004058769A3

    公开(公告)日：2004-09-30

    申请号：PCT/US0339990

    申请日：2003-12-17

    申请人： VERTEX PHARMA ,  GREEN JEREMY ,  GREY RONALD JR ,  PIERCE ALBERT C

    发明人： GREEN JEREMY ,  GREY RONALD JR ,  PIERCE ALBERT C

    IPC分类号： A61K31/495 ,  A61K31/503 ,  A61K31/5377 ,  A61K31/541 ,  C07D487/04

    CPC分类号： C07D487/04 ,  A61K31/495 ,  A61K31/503 ,  A61K31/5377 ,  A61K31/541

    摘要： The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of PIM-1, CDK-2, GSK-3, and SRC mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

    摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐。 这些化合物是蛋白激酶的抑制剂，特别是PIM-1，CDK-2，GSK-3和SRC哺乳动物蛋白激酶的抑制剂。 本发明还提供包含本发明化合物的药学上可接受的组合物和利用这些化合物和组合物治疗各种蛋白激酶介导的病症的方法。

    PHARMACEUTICAL COMPOSITIONS COMPRISING A DECONGENSTANT AND FURTHER ACTIVE INGREDIENTS FOR TREATING COUGH AND FLU
    8.
    发明申请
    PHARMACEUTICAL COMPOSITIONS COMPRISING A DECONGENSTANT AND FURTHER ACTIVE INGREDIENTS FOR TREATING COUGH AND FLU 审中-公开
    包含一种中间体和更多活性成分的药物组合物，用于治疗咳嗽和流感

    公开(公告)号：WO03089007B1

    公开(公告)日：2003-12-24

    申请号：PCT/IB0301197

    申请日：2003-04-02

    申请人： ADCOCK INGRAM INTELLECTUAL PRO ,  PARSONS BRADLEY RYAN ,  DU PLESSIS ERICA LYNNE

    发明人： PARSONS BRADLEY RYAN ,  DU PLESSIS ERICA LYNNE

    IPC分类号： A61K31/137 ,  A61K31/416 ,  A61K31/503 ,  A61K45/06 ,  A61P27/14 ,  A61P43/00

    CPC分类号： A61K31/416 ,  A61K31/137 ,  A61K31/503 ,  A61K45/06 ,  A61K2300/00

    摘要： A pharmaceutical composition comprises a combination of a decongestant such as phenylephrine, pseudoephedrine or phenylpropanolamine or a pharmaceutically acceptable salt or derivative thereof, and at least one other active ingredient selected from a non-steriodal anti-inflammatory, an anti-histamine, a local anaesthetic, an antiseptic anaesthetic and a cough suppressant, and a pharmaceutically acceptable carrier. The pharmaceutical composition, which is provided in the form of a lozenge, tablet, capsule, mouthwash, gargle or spray, in particular a lozenge, is suitable for the symptomatic relief of cough and flu, including but not limited to that associated with sore throats and congested nasal passages.

    摘要翻译： 药物组合物包含减充血剂如去氧肾上腺素，伪麻黄碱或苯丙醇胺或其药学上可接受的盐或衍生物与至少一种选自非甾体抗炎药，抗组胺药，局部麻醉剂 ，防腐麻醉剂和咳嗽抑制剂，以及药学上可接受的载体。 以锭剂，片剂，胶囊，漱口剂，漱口剂或喷雾剂，特别是锭剂形式提供的药物组合物适用于咳嗽和流感的症状缓解，包括但不限于与喉咙痛 和拥挤的鼻道。

    COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN
    9.
    发明申请
    COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN 审中-公开
    化合物和治疗疼痛的方法

    公开(公告)号：WO01047925A1

    公开(公告)日：2001-07-05

    申请号：PCT/SE2000/002609

    申请日：2000-12-19

    IPC分类号： A61K31/502 ,  A61K31/5025 ,  A61K31/503 ,  A61K31/5377 ,  A61K31/541 ,  A61P29/00 ,  C07D471/04 ,  C07D487/04

    CPC分类号： C07D471/04 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/503 ,  A61K31/5377 ,  A61K31/541 ,  C07D487/04

    摘要： Compounds according to structural diagram (I) are disclosed; wherein R , A and D are as defined in the specification. Also disclosed are methods for treating pain comprising administration of a pain-ameliorating effective amount of a compound in accord with structural diagram (I) and pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram (I).

    摘要翻译： 公开了根据结构图（I）的化合物; 其中R 1，A和D如说明书中所定义。 还公开了治疗疼痛的方法，其包括根据结构图（I）施用疼痛改善的有效量的化合物和根据结构图（I）包含疼痛改善的有效量的化合物的药物组合物。