公开(公告)号：WO1991013154A1

公开(公告)日：1991-09-05

申请号：PCT/NL1991000033

申请日：1991-02-28

Applicant: GIST-BROCADES N.V.

Inventor： GIST-BROCADES N.V. ,  VAN DIJL, Jan, Maarten ,  SMITH, Hilde, E. ,  BRON, Sierd ,  QUAX, Wilhelmus, Johannes

IPC: C12N15/57

CPC classification number: C12N9/2417 ,  C07K2319/02 ,  C07K2319/034 ,  C07K2319/036 ,  C07K2319/61 ,  C12N9/52 ,  C12N9/86 ,  C12N15/625 ,  C12N15/67 ,  C12N15/70 ,  C12N15/75

Abstract: The subject invention describes the cloning and overexpression of leader peptidase genes. A method for isolating a leader peptidase gene is disclosed. Overexpression of the signal peptidase in a suitable host species leads to an enhanced rate of protein processing.