公开(公告)号：WO2021148614A1

公开(公告)日：2021-07-29

申请号：PCT/EP2021/051472

申请日：2021-01-22

Applicant: GLYCOM A/S

Inventor： PEDERSEN, Margit ,  KAMPMANN, Katrine, Bych

IPC: C07K14/195 ,  C12P19/04

Abstract: The present invention relates to the field of recombinant production of biological molecules in host cells. More particularly it relates to a method for recombinant production of human milk oligosaccharides (HMO) using a genetically modified cell expressing a protein of the major facilitator superfamily (MFS).

公开(公告)号：WO2021148618A1

公开(公告)日：2021-07-29

申请号：PCT/EP2021/051476

申请日：2021-01-22

Applicant: GLYCOM A/S

Inventor： PEDERSEN, Margit ,  D'ARRIGO, Isotta ,  KAMPMANN, Katrine, Bych ,  PAPADAKIS, Manos

IPC: C12N15/70 ,  C12P19/00 ,  C07H3/06

Abstract: The present invention relates to the field of recombinant production of biological molecules in genetically modified cells. More particularly, it relates to a method for recombinant production of human milk oligosaccharides (HMO) using a genetically modified cell expressing a protein of the major facilitator superfamily (MFS), the protein expressed being Bad.

公开(公告)号：WO2021148615A1

公开(公告)日：2021-07-29

申请号：PCT/EP2021/051473

申请日：2021-01-22

Applicant: GLYCOM A/S

Inventor： PEDERSEN, Margit ,  PAPADAKIS, Manos ,  KAMPMANN, Katrine, Bych

IPC: C07K14/24 ,  C12P19/04

Abstract: The present inventive concept relates to a genetically modified cell enabled for the production of an oligosaccharide, preferably, an HMO, comprising a recombinant nucleic encoding a putative transporter protein of the MFS superfamily; and methods using said cell for the production of oligosaccharide(s), preferably an HMO.

公开(公告)号：WO2021148620A1

公开(公告)日：2021-07-29

申请号：PCT/EP2021/051479

申请日：2021-01-22

Applicant: GLYCOM A/S

Inventor： PEDERSEN, Margit ,  D'ARRIGO, Isotta ,  KAMPMANN, Katrine, Bych ,  PAPADAKIS, Manos

IPC: C12N15/70 ,  C12P19/00 ,  C07H3/06

Abstract: The present invention relates to the field of recombinant production of biological molecules in genetically modified cells. More particularly, it relates to a method for recombinant production of human milk oligosaccharides (HMO) using a genetically modified cell expressing a protein of the major facilitator superfamily (MFS), the protein expressed being Fred.

公开(公告)号：WO2021148611A1

公开(公告)日：2021-07-29

申请号：PCT/EP2021/051468

申请日：2021-01-22

Applicant: GLYCOM A/S

Inventor： PAPADAKIS, Manos ,  KAMPMANN, Katrine, Bych

IPC: C12N15/70 ,  C12P19/00 ,  C07H3/06

Abstract: The present inventive concept relates to a genetically modified cell enabled for the production of an oligosaccharide, preferably, an HMO, comprising a recombinant nucleic acid encoding a protein of the MFS superfamily; and methods using said cell for the production the oligosaccharide, preferably an HMO.