公开(公告)号：WO2022192937A1

公开(公告)日：2022-09-22

申请号：PCT/AU2022/050213

申请日：2022-03-14

申请人： GRIFFITH UNIVERSITY ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： JENNINGS, Michael ,  JEN, Freda (En-Chi) ,  SEIB, Kate ,  SEMCHENKO, Evgeny ,  KIEFEL, Milton ,  APICELLA, Michael

IPC分类号： A61K39/095 ,  A61K31/739 ,  A61K31/702 ,  C07K16/12 ,  A61P31/04

摘要： This disclosure relates generally to Neisseria surface moieties. More particularly, the present disclosure relates to oligosaccharides corresponding to Neisseria lipooligosaccharides and to chimeric molecules comprising these moieties for eliciting an immune response to Neisseria organisms and/or for treating or inhibiting the development of Neisseria infections.

公开(公告)号：WO2021222988A1

公开(公告)日：2021-11-11

申请号：PCT/AU2021/050422

申请日：2021-05-07

申请人： GRIFFITH UNIVERSITY

发明人： JENNINGS, Michael Paul ,  DAY, Christopher James ,  KIEFEL, Milton ,  HASELHORST, Thomas

IPC分类号： A61K38/10 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/655 ,  C07D491/22 ,  C07K7/08 ,  A61P31/14

摘要： The present disclosure relates to peptides comprising an amino acid sequence set forth in SEQ ID NO: 1 or 2. Methods of using these peptides to treat or prevent an infection caused by an angiotensin-converting enzyme 2 (ACE2)-interacting coronavirus, elicit an immune response to an ACE2-interacting coronavirus, detect an infection by an ACE2-interacting coronavirus, or identify agents which inhibit the interaction of an ACE2-interacting coronavirus with the ACE2 receptor, are further disclosed. Furthermore, this disclosure pertains to methods of treating a coronavirus infection comprising the administration of an ACE2- interacting compound, and novel compounds for this purpose.