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    LIPID STABILIZED FORMULATIONS
    1.
    发明申请
    LIPID STABILIZED FORMULATIONS 审中-公开
    脂质稳定剂

    公开(公告)号：WO2006036624A2

    公开(公告)日：2006-04-06

    申请号：PCT/US2005033401

    申请日：2005-09-16

    Applicant: HARTZ MOUNTAIN CORP ,  COTTRELL IAN WILLIAM ,  AHN ALBERT ,  FISHER RICHARD

    Inventor： COTTRELL IAN WILLIAM ,  AHN ALBERT ,  FISHER RICHARD

    IPC: A61K31/517 ,  A61K9/00 ,  A61K31/7048

    CPC classification number: A61K45/06 ,  A61K9/0056 ,  A61K9/1617 ,  A61K31/517 ,  A61K31/7048 ,  A61K2300/00

    Abstract: The present invention provides a lipid based system for isolating components in a pharmaceutical formulation. Also provided are methods for preparing stable pharmaceutical formulations containing at least two active ingredients. Further provided are methods of treating helminthiasis in mammals, which comprises administering a pharmaceutical composition that is highly effective against helminths, particularly tapeworn, hookworm, roundworm and heartworm of domestic animals and farm animals.

    Abstract translation: 本发明提供了用于分离药物制剂中的组分的基于脂质的系统。 还提供了用于制备含有至少两种活性成分的稳定药物制剂的方法。 进一步提供了治疗哺乳动物蠕虫病的方法，其包括施用对家畜和农场动物的蠕虫，特别是带卷虫，钩虫，蛔虫和心丝虫非常有效的药物组合物。

    TOPICAL INSECTICIDE
    3.
    发明申请
    TOPICAL INSECTICIDE 审中-公开
    主题杀虫剂

    公开(公告)号：WO2004023873A3

    公开(公告)日：2007-04-26

    申请号：PCT/US0328945

    申请日：2003-09-11

    Applicant: HARTZ MOUNTAIN CORP ,  COTTRELL IAN WILLIAM ,  AHN ALBERT ,  LYTWYN MICHAEL WILLIAM

    Inventor： COTTRELL IAN WILLIAM ,  AHN ALBERT ,  LYTWYN MICHAEL WILLIAM

    IPC: A01N25/00 ,  A01N51/00

    CPC classification number: A01N51/00 ,  A01N25/02 ,  A01N2300/00

    Abstract: A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas, dissolved in a solvent such as ethanol and/or DPM.

    Abstract translation: 提供了一种局部用杀虫剂，其可以安全使用并避免常规外用杀虫剂的许多常见的有害副作用。 在本发明的一个优选实施方案中，杀虫剂制剂的活性成分是具有硝基亚甲基，硝基氨基或氰基氨基的胺衍生物，其可配制成具有低毒性和优异的杀虫活性。 一种特别合适的杀虫剂是1-{（四氢-3-呋喃基）甲基} -2-硝基-3-甲基胍（dinotefuran），一种杀死成年跳蚤的aldulticide，溶解在溶剂如乙醇和/或DPM中。

    HIGH CONCENTRATION DINOTEFURAN FORMULATIONS CONTAINING METHOPRENE
    4.
    发明申请
    HIGH CONCENTRATION DINOTEFURAN FORMULATIONS CONTAINING METHOPRENE 审中-公开
    含有甲基的高浓度DINOTEFURA配方

    公开(公告)号：WO2004095922A3

    公开(公告)日：2007-03-08

    申请号：PCT/US0335582

    申请日：2003-11-06

    Applicant: HARTZ MOUNTAIN CORP

    Inventor： COTTRELL IAN WILLIAM ,  LYTWYN MICHAEL WILLIAM ,  AHN ALBERT

    IPC: A01N25/00 ,  A01N43/08 ,  A01N47/40 ,  A01N51/00

    CPC classification number: A01N51/00 ,  A01N43/08 ,  A01N47/40 ,  A01N49/00 ,  A01N43/40 ,  A01N25/02 ,  A01N2300/00

    Abstract: A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas combined with methoprene.

    Abstract translation: 提供了一种局部用杀虫剂，其可以安全使用并避免常规外用杀虫剂的许多常见的有害副作用。 在本发明的一个优选实施方案中，杀虫剂制剂的活性成分是具有硝基亚甲基，硝基氨基或氰基氨基的胺衍生物，其可配制成具有低毒性和优异的杀虫活性。 一种特别合适的杀虫剂是1 {（四氢-3-呋喃基）甲基} -2-硝基-3-甲基胍（dinotefuran），一种杀死成年跳蚤与甲氧虫酯组合的杀菌剂。

    HIGH CONCENTRATION MULTIACTION TOPICAL INSECTICIDES CONTAINING PYRETHROIDS
    5.
    发明申请
    HIGH CONCENTRATION MULTIACTION TOPICAL INSECTICIDES CONTAINING PYRETHROIDS 审中-公开
    含有吡咯烷酮的高浓度多功能药用杀虫剂

    公开(公告)号：WO2007011602A2

    公开(公告)日：2007-01-25

    申请号：PCT/US2006027023

    申请日：2006-07-11

    Applicant: HARTZ MOUNTAIN CORP ,  COTTRELL IAN WILLIAM ,  AHN ALBERT ,  FISHER RICHARD ,  MONRO CHRISTINE ,  JOSEPH PIERRE

    Inventor： COTTRELL IAN WILLIAM ,  AHN ALBERT ,  FISHER RICHARD ,  MONRO CHRISTINE ,  JOSEPH PIERRE

    IPC: A01N43/40 ,  A01N25/34 ,  A01N37/18 ,  A01N37/34 ,  A01N43/08 ,  A01N53/00

    CPC classification number: A01N47/40 ,  A01N25/34 ,  A01N53/00 ,  Y10S514/875 ,  Y10S514/97 ,  A01N43/40 ,  A01N49/00 ,  A01N51/00 ,  A01N57/12 ,  A01N2300/00 ,  A01N25/02

    Abstract: A topical insecticide preparation is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The topical insecticide contains a combination of a first pyrethroid insecticide effective for killing fleas, a second pyrethroid insecticide effective for killing ticks, and an insect growth regulator (IGR). The topical insecticide preparation can be packaged together or packaged so that the first and second pyrethroid insecticides are stored separately prior to administration of the insecticide preparation to the animal. The combination of the first and second pyrethroid insecticides with an insect growth regulator results in an insecticide preparation formulated to have enhanced insecticidal activity against fleas and ticks compared to the effectiveness of the first and second insecticides used alone. Further, the combination of the first and second pyrethroid insecticides with an insect growth regulator produces an insecticide preparation having enhanced insecticidal activity against fleas and ticks while advantageously minimizing the total amount of insecticide needed for its effectiveness.

    Abstract translation: 提供一种局部用的杀虫剂制剂，其可以安全使用并避免常规外用杀虫剂的许多常见的有害副作用。 局部杀虫剂包含有效杀死蚤的第一拟除虫菊酯杀虫剂，有效杀死蜱的第二拟除虫菊酯杀虫剂和昆虫生长调节剂（IGR）的组合。 局部杀虫剂可以包装在一起或包装，使得第一和第二拟除虫菊酯杀虫剂在向杀虫剂给药之前分开储存。 第一和第二拟除虫菊酯杀虫剂与昆虫生长调节剂的组合产生了与单独使用的第一种和第二种杀虫剂的有效性相比，配制的杀虫剂制剂对跳蚤和蜱具有增强的杀虫活性。 此外，第一和第二拟除虫菊酯杀虫剂与昆虫生长调节剂的组合产生了对跳蚤和蜱具有增强的杀虫活性的杀虫剂制剂，同时有利地最小化其有效性所需的杀虫剂总量。

    MULTI-ACTION ANTHELMINTIC FORMULATIONS
    7.
    发明申请
    MULTI-ACTION ANTHELMINTIC FORMULATIONS 审中-公开
    多动作安定剂制剂

    公开(公告)号：WO2005094210A3

    公开(公告)日：2006-03-30

    申请号：PCT/US2004025001

    申请日：2004-08-03

    Applicant: HARTZ MOUNTAIN CORP ,  CHANELLE PHARMACEUTICALS MFG L

    Inventor： AHN ALBERT ,  COTTRELL IAN

    IPC: A61K31/513 ,  A61K31/7048 ,  A61K31/407 ,  A61P33/10

    CPC classification number: A61K31/513 ,  A61K31/407 ,  A61K2300/00

    Abstract: The present invention provides a method for preparing a pharmaceutical formulation containing ivermectin and a method and composition that can contain ivermectin plus tetrahydropyrimidines. An examples of a tetrahydropyrimidine includes pyrantel. A pharmaceutical formulation is provided for use in the treatment of helminthiasis of mammals, and particularly tapeworm, hookworm, roundworm and heartworm of domestic animals and farm animals. The present invention also provides a method of treating helminthiasis in mammals, which method comprises administering to the mammal in need thereof an anthelmintically effective amount of a pharmaceutical formulation of the invention.

    Abstract translation: 本发明提供了制备含有伊维菌素的药物制剂的方法和可含有伊维菌素加四氢嘧啶的方法和组合物。 四氢嘧啶的实例包括吡喃酮。 提供药物制剂用于治疗哺乳动物，特别是家畜和农场动物的绦虫，钩虫，蛔虫和心虫的蠕虫病。 本发明还提供了一种治疗哺乳动物蠕虫病的方法，该方法包括向有需要的哺乳动物施用驱虫有效量的本发明的药物制剂。

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