公开(公告)号：WO2012148538A3

公开(公告)日：2013-03-07

申请号：PCT/US2012026298

申请日：2012-02-23

申请人： HEALTH RESEARCH INC ,  SEON BEN K ,  TOI HIROFUMI

发明人： SEON BEN K ,  TOI HIROFUMI

IPC分类号： A61K39/395 ,  A61K47/48 ,  A61K48/00 ,  A61P35/00

CPC分类号： C07K14/70596 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/0375 ,  A61K2039/505 ,  C07K16/2896 ,  C07K16/30 ,  C12N5/0606 ,  C12N15/85

摘要： Provided are compositions and methods that relate to prophylaxis and therapy of angiogenesis associated disease and includes novel knockin mice which express novel human/mouse chimeric endoglin, vectors for use in making such mice, and murine embryonic stem cells comprising the novel human/mouse transgene. Also provided are anti-human endoglin monoclonal antibodies (mAbs) which can be used as antiangiogenic agents for prophylaxis or therapy of human tumor angiogenesis and human angiogenesis-associated diseases having excessive vascularization. The mAbs do not cross react with murine endoglin. Also provides are methods for using the anti -human endoglin mAbs for prophylaxis or therapy of human tumor angiogenesis and for angiogenesis-associated diseases having excessive vascularization.

摘要翻译： 提供了涉及血管生成相关疾病的预防和治疗的组合物和方法，并且包括表达新型人/小鼠嵌合内皮糖蛋白的新型敲入小鼠，用于制备这种小鼠的载体和包含新型人/小鼠转基因的鼠胚胎干细胞。 还提供了抗人内皮糖蛋白单克隆抗体（mAb），其可以用作抗血管生成剂用于预防或治疗人肿瘤血管发生和具有过度血管形成的人血管生成相关疾病。 mAb不与鼠内皮糖蛋白交叉反应。 还提供了使用抗人内皮糖蛋白mAb来预防或治疗人类肿瘤血管生成和血管生成相关疾病，具有过度血管形成的方法。