公开(公告)号：WO2018208927A1

公开(公告)日：2018-11-15

申请号：PCT/US2018/031817

申请日：2018-05-09

Applicant: HEARTFLOW, INC.

Inventor： GRADY, Leo ,  PETERSEN, Peter, Kersten ,  SCHAAP, Michiel ,  LESAGE, David

IPC: G06T7/149

Abstract: Systems and methods are disclosed for anatomic structure segmentation in image analysis, using a computer system. One method includes: receiving an annotation and a plurality of keypoints for an anatomic structure in one or more images; computing distances from the plurality of keypoints to a boundary of the anatomic structure; training a model, using data in the one or more images and the computed distances, for predicting a boundary in the anatomic structure in an image of a patient's anatomy; receiving the image of the patient's anatomy including the anatomic structure; estimating a segmentation boundary in the anatomic structure in the image of the patient's anatomy; and predicting, using the trained model, a boundary location in the anatomic structure in the image of the patient's anatomy by generating a regression of distances from keypoints in the anatomic structure in the image of the patient's anatomy to the estimated boundary.

公开(公告)号：WO2020236639A1

公开(公告)日：2020-11-26

申请号：PCT/US2020/033239

申请日：2020-05-15

Applicant: HEARTFLOW, INC.

Inventor： SANKARAN, Sethuraman ,  LESAGE, David ,  TAYLOR, Charles ,  XIAO, Nan ,  KIM, Hyun, Jin ,  SPAIN, David ,  SCHAAP, Michiel

IPC: G16H50/50

Abstract: Systems and methods are disclosed for blood flow simulation. For example, a method may include performing a plurality of blood flow simulations using a first model of vascular blood flow, each of the plurality of blood flow simulations simulating blood flow in a vasculature of a patient or a geometry based on the vasculature of the patient; based on results of the plurality of blood flow simulations, generating a response surface mapping one or more first parameters of the first model to one or more second parameters of a reduced order model of vascular blood; determining values for the one or more parameters of the reduced order model mapped, by the response surface, from parameter values representing a modified state of the vasculature; and performing simulation using the reduced order model parameterized by the determined values, to determine a blood flow characteristic of the modified state of the vasculature.