公开(公告)号：WO1997045397A1

公开(公告)日：1997-12-04

申请号：PCT/US1997006602

申请日：1997-04-24

Applicant: HOECHST MARION ROUSSEL, INC.

Inventor： HOECHST MARION ROUSSEL, INC. ,  JONES, Winton, D. ,  CISKE, Fred, L. ,  DINERSTEIN, Robert, J. ,  DIEKEMA, Keith, A.

IPC: C07C217/24

CPC classification number: C07D295/088 ,  C07C217/24 ,  C07C235/44 ,  C07C2603/18

Abstract: The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase C activity in mammals, including humans. More specifically, the present compounds are useful for the treatment of neoplastic disease states, disorders associated with abnormal blood flow (including hypertension, ischemia, atherosclerosis, coagulation disorders), and inflammatory diseases (including immune disorders, asthma, lung fibrosis, and psoriasis).

Abstract translation: 本发明描述了抑制蛋白激酶C的某些烷氧基氨基取代的芴酮，以及包括这些化合物的药物组合物以及使用这些化合物控制哺乳动物（包括人）中的蛋白激酶C活性的方法。 更具体地说，本发明化合物可用于治疗肿瘤疾病状态，与异常血流（包括高血压，缺血，动脉粥样硬化，凝血障碍）和炎性疾病（包括免疫疾病，哮喘，肺纤维化和牛皮癣）相关的疾病， 。