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1.发明申请METHODS FOR POTENTIATING AN IMMUNE RESPONSE USING DEPOT-FORMING AND NON-DEPOT-FORMING VACCINES 审中-公开使用成矿形成和非成矿疫苗潜伏免疫反应的方法
公开(公告)号：WO2016176761A1
公开(公告)日：2016-11-10
申请号：PCT/CA2016/050487
申请日：2016-04-27
发明人： MANSOUR, Marc , WEIR, Genevieve Mary , SAMMATUR, Leeladhar , RAJAGOPALAN, Rajkannan , STANFORD, Marianne , MACDONALD, Lisa Diana
CPC分类号： C07K14/025 , A61K9/00 , A61K9/0019 , A61K9/127 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K47/24 , A61K47/26 , A61K47/28 , A61K2039/55555 , A61K2039/55561 , A61K2039/572 , A61P35/00 , C12N2710/20023 , C12N2710/20034 , Y02A50/412
摘要： The present disclosure provides methods, vaccines and kits for potentiating an immune response to an antigen in a subject. The methods comprise administering to the subject at least one dose of a depot-forming vaccine comprising one or more antigens in a hydrophobic carrier; and subsequently administering to the subject at least one dose of a non-depot-forming vaccine comprising the one or more antigens.
摘要翻译： 本公开提供了用于增强受试者中抗原的免疫应答的方法，疫苗和试剂盒。 所述方法包括向所述受试者施用至少一个剂量的包含在疏水载体中的一种或多种抗原的贮库形成疫苗; 并且随后向所述受试者施用至少一个剂量的包含所述一种或多种抗原的非贮库形成疫苗。
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2.发明申请ADJUVANTING SYSTEMS AND WATER-FREE VACCINE COMPOSITIONS COMPRISING A POLYI:C POLYNUCLEOTIDE ADJUVANT AND A LIPID-BASED ADJUVANT 审中-公开包含PolyI：C多核苷酸佐剂和基于脂质的佐剂的佐剂体系和无水疫苗组合物
公开(公告)号：WO2017083963A1
公开(公告)日：2017-05-26
申请号：PCT/CA2016/051324
申请日：2016-11-15
CPC分类号： A61K39/39 , A61K39/07 , A61K39/12 , A61K2039/55516 , A61K2039/55561 , A61K2039/55572 , C12N2710/20034 , C12N2760/16134 , Y02A50/412
摘要： The present disclosure provides adjuvanting systems comprising: (a) a polyI:C polynucleotide adjuvant; (b) a lipid-based adjuvant;(c) an amphipathic compound; and (d) a hydrophobic carrier. Also provided are vaccine compositions that are water-free or substantially free of water, which comprise the same components together with one or more antigens. The disclosure also provides uses for such compositions in inducing an antibody (humoral) and/or cell-mediated immune response and methods for their use in the treatment of a disease, disorder or ailment ameliorated by an antibody and/or cell-mediated immune response.
摘要翻译： 本公开提供佐剂系统，其包含：（a）polyI：C多核苷酸佐剂; （b）基于脂质的佐剂;（c）两亲化合物; 和（d）疏水性载体。 还提供了无水或基本上不含水的疫苗组合物，其包含与一种或多种抗原一起的相同组分。 本公开内容还提供了这种组合物在诱导抗体（体液）和/或细胞介导的免疫应答中的用途以及它们用于治疗由抗体和/或细胞介导的免疫应答改善的疾病，病症或疾病的方法
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公开(公告)号：WO2005014816A1
公开(公告)日：2005-02-17
申请号：PCT/CA2004/001471
申请日：2004-08-06
IPC分类号： C12N15/12
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00
摘要： The present invention provides immunocontraceptive vaccines comprising a zona pellucida (ZP) polypeptide construct, and/or a variant thereof, from a carnivorous mammal such as cat, dog, ferret or mink. Such vaccines are useful in reducing fertility of cats and/or dogs.
摘要翻译： 本发明提供了包含来自食肉哺乳动物如猫，狗，白鼬或貂的透明带（ZP）多肽构建体和/或其变体的免疫避孕疫苗。 这种疫苗可用于降低猫和/或狗的生育力。
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4.发明申请COMPOSITIONS COMPRISING LIPOSOMES, AN ANTIGEN, A POLYNUCLEOTIDE AND A CARRIER COMPRISING A CONTINUOUS PHASE OF A HYDROPHOBIC SUBSTANCE 审中-公开包含脂质体，抗原，多核苷酸和包含疏水性物质的连续相的载体的组合物
公开(公告)号：WO2009146523A1
公开(公告)日：2009-12-10
申请号：PCT/CA2009/000692
申请日：2009-05-22
申请人： IMMUNOVACCINE TECHNOLOGIES INC. , MANSOUR, Marc , SAMMATUR, Leeladhar , MACDONALD, Lisa Diana , KARKADA, Mohan , WEIR, Genevieve Mary , FUENTES-ORTEGA, Antar
发明人： MANSOUR, Marc , SAMMATUR, Leeladhar , MACDONALD, Lisa Diana , KARKADA, Mohan , WEIR, Genevieve Mary , FUENTES-ORTEGA, Antar
CPC分类号： A61K39/00 , A61K9/10 , A61K9/107 , A61K9/127 , A61K9/19 , A61K31/785 , A61K47/06 , A61K2039/55555 , A61K2039/55561 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/464 , Y02A50/466
摘要： The invention provides a composition comprising: an antigen; liposomes; a polyI:C polynucleotide; and a carrier comprising a continuous phase of a hydrophobic substance. Methods for making and using the compositions are also provided.
摘要翻译： 本发明提供一种组合物，其包含：抗原; 脂质体; polyI：C多核苷酸; 和包含疏水性物质的连续相的载体。 还提供了制备和使用组合物的方法。
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公开(公告)号：WO2003066680A2
公开(公告)日：2003-08-14
申请号：PCT/CA2003/000177
申请日：2003-02-10
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00
摘要： The present invention provides immunocontraceptive vaccines comprising a zona pellucida (ZP) polypeptide, and/or a variant thereof, from a carnivorous mammal such as cat, dog, ferret or mink. Such vaccines are useful in reducing fertility of cats and/or dogs.
摘要翻译： 本发明提供了一种免疫避孕疫苗，其包含来自食肉哺乳动物如猫，狗，白鼬或貂的透明带ZP多肽和/或其变体。 这种疫苗可用于降低猫和/或狗的生育力。
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6.发明申请METHODS OF USING LOW DOSE VOLUME B-CELL EPITOPE COMPOSITIONS FOR INDUCING AN ANTIBODY IMMUNE RESPONSE IN HUMAN SUBJECTS 审中-公开使用低剂量体积B细胞表位组合物在人类受试者中诱导抗体免疫应答的方法
公开(公告)号：WO2018058230A1
公开(公告)日：2018-04-05
申请号：PCT/CA2016/051127
申请日：2016-09-27
发明人： MANSOUR, Marc , ORS, Frederic , STANFORD, Marianne , SAMMATUR, Leeladhar , RAJAGOPALAN, Rajkannan , MACDONALD, Lisa Diana
摘要： The present disclosure provides methods, uses and compositions and kits for use in inducing an antibody immune response in a human subject. The methods and uses involve administering parenterally a low dose volume of a composition comprising an antigen comprising a B-cell epitope, an amphipathic compound, and a hydrophobic carrier, wherein the low dose volume of the composition is less than 100 µl and induces an antibody immune response to the B-cell epitope in the human subject.
摘要翻译： 本公开内容提供了用于在人受试者中诱导抗体免疫应答的方法，用途和组合物以及试剂盒。 所述方法和用途涉及胃肠外施用低剂量体积的包含含有B细胞表位，两亲化合物和疏水性载体的抗原的组合物，其中所述组合物的低剂量体积小于100微升并且诱导 对人受试者中B细胞表位的抗体免疫应答。
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7.发明申请COMPOSITIONS COMPRISING AN ANTIGEN, AN AMPHIPATHIC COMPOUND AND A HYDROPHOBIC CARRIER, AND USES THEREOF 审中-公开包含抗原，AMPHIPATHIC化合物和疏水性载体的组合物及其用途
公开(公告)号：WO2009043165A1
公开(公告)日：2009-04-09
申请号：PCT/CA2008/001747
申请日：2008-10-02
发明人： MANSOUR, Marc
CPC分类号： A61K9/0019 , A61K9/0031 , A61K9/0043 , A61K9/0056 , A61K39/0011 , A61K39/39 , A61K47/24 , A61K2039/55511 , A61K2039/55566
摘要： The present invention provides compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, wherein the antigen is suspended in said hydrophobic carrier in the substantial absence of water and methods of using these compositions for inducing an antibody or cell-mediated response in a subject.
摘要翻译： 本发明提供了包含抗原，两亲性化合物和疏水载体的组合物，其中基本上不含水将抗原悬浮在所述疏水性载体中，以及使用这些组合物在受试者中诱导抗体或细胞介导的应答的方法 。
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8.发明申请USE OF LIPOSOMES IN A CARRIER COMPRISING A CONTINUOUS HYDROPHOBIC PHASE AS A VEHICLE FOR CANCER TREATMENT 审中-公开在包含连续作为车辆治疗的车辆的连续水相中的载体中的脂质体的使用
公开(公告)号：WO2007041832A1
公开(公告)日：2007-04-19
申请号：PCT/CA2006/001640
申请日：2006-10-05
申请人： IMMUNOVACCINE TECHNOLOGIES INC. , DAFTARIAN, Pirouz, M. , MANSOUR, Marc , POHAJDAK, Bill , BROWN, Robert, G. , KAST, Wijbe, M.
CPC分类号： A61K9/127 , A01K2267/0331 , A61K9/0024 , A61K31/4745 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/385 , A61K47/646 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/585 , A61K2039/6031 , A61K2039/6037 , A61K2039/622 , A61K2039/627 , A61K2039/70 , C07K14/005 , C07K14/4748 , C07K2319/00 , C12N9/90 , C12N2710/20022 , C12N2710/20034 , C12Y503/03012
摘要： The invention compositions comprising a continuous hydrophobic phase and liposomes as a vehicle for delivery of an antigen capable of inducing a cytotoxic T lymphocyte (CTL) response and methods for their use in the treatment of cancer.
摘要翻译： 包含连续疏水相和脂质体作为递送能够诱导细胞毒性T淋巴细胞（CTL）应答的抗原的载体的本发明组合物及其用于治疗癌症的方法。
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公开(公告)号：WO2016109880A1
公开(公告)日：2016-07-14
申请号：PCT/CA2015/051309
申请日：2015-12-11
发明人： JIANG, Zi-hua , LEWICKY, Jordan David , WEIR, Genevieve Mary , RAJAGOPALAN, Rajkannan , SAMMATUR, Leeladhar , STANFORD, Marianne Michelle , MANSOUR, Marc
IPC分类号： C07H15/18 , A61K31/7028 , A61K39/39 , A61P25/30 , A61P31/00 , A61P35/00 , A61P37/02 , C07H13/06
CPC分类号： C07H11/04 , A61K31/7028 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K2039/55555 , A61K2039/55572 , A61K2039/585 , A61K2039/6031 , A61K2039/6037 , A61K2039/605 , C07H15/18 , C12N7/00 , C12N2710/20034 , C12N2710/20071 , Y02A50/412
摘要： The invention provides lipid A mimics in which one or both of the sugar residues of a natural lipid A disaccharide backbone has been replaced with an aromatic group. These lipid A mimics may further differ from a natural lipid A molecule with respect to other structural characteristics, such as, a different number of phosphate groups present, changes in the number, structure and location of lipid chains and/or changes in the spacing and linkage of the sugar residues (or their aromatic replacements). The lipid A mimics may be lipid A agonists and as such may be useful as immunostimulatory agents in inducing or patenting an antibody and/or cell-mediated immune response, or may be lipid A antagonists and as such may be useful in treating or preventing a lipopolysaccharide (LPS)/lipid A-mediated disease or disorder. Also provided are methods for preparing the lipid A mimics.
摘要翻译： 本发明提供脂质A模拟物，其中天然脂质A二糖主链的一个或两个糖残基已被芳族基团取代。 这些脂质A模拟物可以与天然脂质A分子相对于其它结构特征进一步不同，例如存在的不同数量的磷酸酯基团，脂质链的数量，结构和位置的变化和/或间隔的变化，和 糖残基（或其芳香族取代基）的连接。 脂质A模拟物可以是脂质A激动剂，因此可用作诱导或授权抗体和/或细胞介导的免疫应答的免疫刺激剂，或者可以是脂质A拮抗剂，因此可用于治疗或预防 脂多糖（LPS）/脂质A介导的疾病或病症。 还提供了制备脂质A模拟物的方法。
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10.发明申请
公开(公告)号：WO2014153636A1
公开(公告)日：2014-10-02
申请号：PCT/CA2013/050248
申请日：2013-03-27
IPC分类号： A61K39/39 , A61K31/675 , A61K39/00 , A61P35/00
CPC分类号： A61K39/39 , A61K9/127 , A61K31/675 , A61K39/0011 , A61K39/05 , A61K2039/545 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/6037 , A61K2039/70 , A61K2300/00
摘要： The present invention provides methods for improving the efficacy of a vaccine in the treatment of cancer. The methods of the invention comprise the administration of at least two doses of an agent that interferes with DNA replication prior to vaccination with a survivin vaccine. Also provided are compositions for use in the methods of the invention.
摘要翻译： 本发明提供了用于改善疫苗在治疗癌症中的功效的方法。 本发明的方法包括在用存活蛋白疫苗接种之前施用至少两剂剂量的干扰DNA复制的试剂。 还提供了用于本发明方法的组合物。
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