公开(公告)号：WO2015159097A3

公开(公告)日：2015-12-30

申请号：PCT/GB2015051163

申请日：2015-04-17

Applicant: IMP INNOVATIONS LTD

Inventor： KALISZCZAK MACIEJ ADAM ,  ABOAGYE ERIC OFORI

IPC: G01N33/50

CPC classification number: G01N33/5008 ,  G01N2800/52

Abstract: The invention provides a method for identifying a subject with a disease or condition characterised by the presence of unwanted cells as being likely to respond to treatment comprising administration of a KDAC6 inhibitor having the structure of Formula (I), wherein said method comprises determining whether the subject's unwanted cells have or are likely to have an increased dependency on autophagy for survival, and wherein Formula (I) comprises: (Formula (I)).

Abstract translation: 本发明提供用于鉴定具有疾病或病症特征的受试者的方法，其特征在于存在可能对治疗有反应的不希望的细胞，包括施用具有式（I）结构的KDAC6抑制剂，其中所述方法包括确定是否 受试者的不想要的细胞具有或可能对生存的自噬增加依赖性，并且其中式（I）包含：（式（I））。