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    DILUENT PREPARATION MODULES AND UNITS
    4.
    发明申请
    DILUENT PREPARATION MODULES AND UNITS 审中-公开

    公开(公告)号：WO2019104198A2

    公开(公告)日：2019-05-31

    申请号：PCT/US2018/062286

    申请日：2018-11-21

    Applicant: BECKMAN COULTER, INC.

    Inventor： VEINER, Craig Randall

    IPC: G01N1/38

    CPC classification number: G01N35/1016 ,  G01N1/38 ,  G01N33/5008 ,  G01N33/5302 ,  G01N35/00693 ,  G01N35/1002 ,  G01N2001/383 ,  G01N2035/1058

    Abstract: Certain types of automated medical analysis equipment are used to analyze blood or other fluids. The equipment may thus use various diluents or reagents that allow the blood or other fluids to be run through the analysis equipment for analysis and data collection. Disclosed is a diluent preparation module that combines purified water and reagent concentrate for use by this equipment. Also disclosed is a diluent preparation unit that combines more than one diluent preparation modules for redundancy and back-up purposes. Also disclosed are systems for supplying the Diluent prepared by the diluent preparation module or diluent preparation unit to one or more analytic instruments.

    LIGHT-GATED SIGNALING MODULATION
    7.
    发明申请
    LIGHT-GATED SIGNALING MODULATION 审中-公开
    光门控信号调制

    公开(公告)号：WO2017144620A1

    公开(公告)日：2017-08-31

    申请号：PCT/EP2017/054246

    申请日：2017-02-23

    Applicant: MAX PLANCK FLORIDA INSTITUTE FOR NEUROSCIENCE ,  MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

    Inventor： KWON, Hyungbae ,  LEE, Dongmin

    IPC: C12N15/62 ,  G01N33/68

    CPC classification number: G01N33/5008 ,  C07K14/035 ,  C07K14/245 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/41 ,  C07K2319/43 ,  C07K2319/50 ,  C12N9/1241 ,  C12N9/22

    Abstract: The present invention relates to a nucleic acid molecule encoding a fusion protein, wherein the nucleic acid molecule comprises: (a) a first nucleic acid sequence encoding a transmembrane domain linked to a first biosensor, wherein said first biosensor is a first molecule capable of interacting with a second molecule to form part of a first inducible interaction module, and wherein said first biosensor is linked to the transmembrane domain such that the first biosensor is located intracellularly upon expression of the fusion protein in a cell; (b) a second nucleic acid sequence encoding an effector-activating module, wherein the effector-activating module comprises: (i) a nucleic acid sequence encoding a first part of a protease, wherein said first part of the protease is capable of interacting with a second part of said protease to form an active form of said protease; or (ii) a nucleic acid sequence encoding a second biosensor, wherein said second biosensor is a first molecule capable of interacting with a second molecule to form part of a second inducible interaction module; (c) a third nucleic acid sequence encoding a third biosensor comprising a protease cleavage site, wherein the protease cleavage site is sterically occluded in the absence of a stimulus for said third biosensor and wherein the protease cleavage site becomes accessible in the presence of said stimulus; and (d) a fourth nucleic acid sequence encoding an effector molecule. The present invention further relates to a vector comprising the nucleic acid molecule of the invention, to sets of nucleic acid molecules, to the sets of nucleic acid molecules of the invention comprised in one or more vectors, to a cell expressing a set of nucleic acid molecules according to the invention as well as to a cell comprising the one or more vectors of the invention. Furthermore, the present invention relates to a method for inducing intracellular signaling, as well as to a method for monitoring intracellular signaling.

    Abstract translation: 本发明涉及编码融合蛋白的核酸分子，其中所述核酸分子包含：（a）编码与第一生物传感器连接的跨膜结构域的第一核酸序列，其中所述第一核酸序列 生物传感器是能够与第二分子相互作用以形成第一可诱导相互作用模块的一部分的第一分子，并且其中所述第一生物传感器与跨膜结构域连接，使得第一生物传感器在融合蛋白在细胞中表达时位于细胞内 ; （b）编码效应子活化模块的第二核酸序列，其中所述效应子活化模块包含：（i）编码蛋白酶的第一部分的核酸序列，其中所述蛋白酶的第一部分能够与 所述蛋白酶的第二部分以形成所述蛋白酶的活性形式; 或（ii）编码第二生物传感器的核酸序列，其中所述第二生物传感器是能够与第二分子相互作用以形成第二可诱导相互作用模块的一部分的第一分子; （c）编码包含蛋白酶切割位点的第三生物传感器的第三核酸序列，其中所述蛋白酶切割位点在对所述第三生物传感器不存在刺激的情况下被空间阻断，并且其中所述蛋白酶切割位点在所述刺激物 ; 和（d）编码效应分子的第四核酸序列。 本发明进一步涉及包含本发明核酸分子，核酸分子集合，包含在一个或多个载体中的本发明核酸分子集合，表达一组核酸分子的细胞的载体 根据本发明的分子以及包含本发明的一种或多种载体的细胞。 此外，本发明涉及用于诱导细胞内信号传导的方法，以及用于监测细胞内信号传导的方法。

    "> METHODS FOR IDENTIFYING INHIBITORS OF
    9.
    发明申请
    METHODS FOR IDENTIFYING INHIBITORS OF "STIMULATOR OF INTERFERON GENE"-DEPENDENT INTERFERON PRODUCTION 审中-公开
    鉴定“干扰素基因刺激因子”抑制剂 - 干扰素产生的方法

    公开(公告)号：WO2017106740A1

    公开(公告)日：2017-06-22

    申请号：PCT/US2016/067315

    申请日：2016-12-16

    Applicant: ADURO BIOTECH, INC.

    Inventor： KATIBAH, George, Edwin ,  KANNE, David ,  SUNG, Leonard ,  LEONG, Justin ,  MCWHIRTER, Sarah, M. ,  DUBENSKY, Thomas, W., Jr.

    IPC: A61K31/7084 ,  A61K39/39 ,  A61K45/06

    CPC classification number: A61K31/7084 ,  A61K39/39 ,  A61K45/06 ,  G01N33/5008

    Abstract: The present invention relates to the use cyclic-di-nucleotide and related scaffold molecules that measurably inhibit STING signaling, and methods for their use in identifying more potent inhibitors of STING signaling. In particular, the methods provided can be used to identify potent inhibitors of STING signaling, which are useful in the treatment of autoimmune and inflammatory diseases. Also provided are compounds having STING inhibitory activity useful in the treatment of autoimmune and inflammatory diseases.

    Abstract translation: 本发明涉及使用可测量地抑制STING信号传导的环二 - 核苷酸和相关支架分子，以及它们用于鉴定更有效的STING信号传导抑制剂的方法。 具体而言，所提供的方法可用于鉴定有效的STING信号传导抑制剂，其可用于治疗自身免疫疾病和炎症性疾病。 还提供了用于治疗自身免疫疾病和炎症疾病的具有STING抑制活性的化合物。

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