公开(公告)号：WO2023031661A1

公开(公告)日：2023-03-09

申请号：PCT/IB2021/059807

申请日：2021-10-27

Applicant: INDIAN INSTITUTE OF TECHNOLOGY KANPUR

Inventor： KUMAR, Ashok ,  ANDRABI, Syed Muntazir

IPC: A61K31/00 ,  A61L15/44

Abstract: The present invention relates to the field of polymeric matrix for haemostatic application. In particular, the Invention provides an efficient polymeric haemostatic device/ bandage with high swelling rate, enhanced mechanical property and high blood clotting ability.

公开(公告)号：WO2012176025A1

公开(公告)日：2012-12-27

申请号：PCT/IB2011/053523

申请日：2011-08-08

Applicant: INDIAN INSTITUTE OF TECHNOLOGY KANPUR ,  KUMAR, Ashok ,  REDDY, Rachamalla, Maheedhar

Inventor： KUMAR, Ashok ,  REDDY, Rachamalla, Maheedhar

IPC: C08F230/06 ,  C08L29/04 ,  C08F220/56 ,  A61K9/00 ,  C08F220/58 ,  C12N5/00 ,  A61K31/736 ,  C08G83/00 ,  C08L33/26 ,  C08F220/34 ,  C08L33/10

CPC classification number: A61K47/32 ,  A61K9/5026 ,  A61K9/5138 ,  A61K31/78 ,  C08F220/56 ,  C08L33/24 ,  C08F220/54 ,  C08F220/34 ,  C08L29/04

Abstract: Provided herein are phenylboronate containing co-polymers (PCC), compositions containing PCC and polyvinyl alcohol (PVA), such compositions further including proteins, methods of making these compositions by water in oil polymerization, and methods of using the protein containing compositions for releasing proteins. Such phenylboronate containing co-polymers are of Formula I: where m, n, p, x, R 1 -R 5 , L, X 1 and X 2 are defined in the application.

Abstract translation: 本文提供含苯基硼酸盐的共聚物（PCC），含有PCC和聚乙烯醇（PVA）的组合物，此类组合物还包括蛋白质，通过水中油聚合制备这些组合物的方法，以及使用含蛋白质组合物释放蛋白质的方法 。 这种苯基硼酸酯的共聚物具有式I：其中m，n，p，x，R 1 -R 5，L，X 1和X 2在本申请中定义。

公开(公告)号：WO2012176023A1

公开(公告)日：2012-12-27

申请号：PCT/IB2011/053521

申请日：2011-08-08

Applicant: INDIAN INSTITUTE OF TECHNOLOGY KANPUR ,  KUMAR, Ashok

Inventor： KUMAR, Ashok

IPC: A61L15/22

CPC classification number: C12N5/0602 ,  A61L27/26 ,  A61L27/38 ,  A61L27/52 ,  Y10T428/3154 ,  Y10T428/31909 ,  Y10T428/31913 ,  Y10T428/3192 ,  C08L29/04 ,  C08L101/02

Abstract: Disclosed herein are biodegradable hydrogel scaffolds for use in tissue engineering. The hydrogel scaffolds are composed of synthetic terpolymers complexed with polyvinyl alcohol (PVA), which facilitate cell-sheet and tissue growth. In the presence of a monosaccharide, the PVA-hydrogel is dissolved and cell-sheets are released for harvesting. Further disclosed herein are methods for producing PVA hydrogels which support tissue growth. Tissue engineering applications and methods are also disclosed.

Abstract translation: 本文公开了用于组织工程的可生物降解的水凝胶支架。 水凝胶支架由与聚乙烯醇（PVA）络合的合成三元共聚物组成，其促进细胞片和组织生长。 在单糖存在下，溶解PVA-水凝胶，释放细胞片进行收获。 本文进一步公开的是用于生产支持组织生长的PVA水凝胶的方法。 还公开了组织工程应用和方法。

公开(公告)号：WO2012176024A1

公开(公告)日：2012-12-27

申请号：PCT/IB2011/053522

申请日：2011-08-08

Applicant: INDIAN INSTITUTE OF TECHNOLOGY KANPUR ,  KUMAR, Ashok

Inventor： KUMAR, Ashok

IPC: C08L29/04 ,  C08F230/06 ,  C08F220/56 ,  A61K9/00 ,  C08F220/58 ,  C12N5/00 ,  A61K31/736 ,  C08G83/00 ,  C08L33/26 ,  C08F220/34 ,  C08L33/10

CPC classification number: C08F16/06 ,  C08F20/00 ,  C08F220/34 ,  C08J9/0061 ,  C08J9/28 ,  C08J2201/0484 ,  C08J2205/022 ,  C08J2205/026 ,  C08J2333/04 ,  C08J2333/24 ,  C08J2343/00 ,  C08J2405/00 ,  C08J2429/04 ,  C08L29/04 ,  C12N5/0068 ,  C12N5/0602 ,  C12N2533/30 ,  C08L33/26

Abstract: A cryogel contains a polyol and a co-polymer of Formula (I).

Abstract translation: 冷冻凝胶含有多元醇和式（I）的共聚物。