公开(公告)号：WO2011097233A1

公开(公告)日：2011-08-11

申请号：PCT/US2011/023352

申请日：2011-02-01

Applicant: INFINITY PHARMACEUTICALS, INC. ,  AUSTAD, Brian, C. ,  GRENIER, Louis ,  GROGAN, Michael, J. ,  LIU, Tao ,  LO, Ching Kam ,  MARTINOT, Theodore, A. ,  YU, Lin-Chen

Inventor： AUSTAD, Brian, C. ,  GRENIER, Louis ,  GROGAN, Michael, J. ,  LIU, Tao ,  LO, Ching Kam ,  MARTINOT, Theodore, A. ,  YU, Lin-Chen

IPC: C07F5/02 ,  A61K31/69

CPC classification number: C07F5/05 ,  C07B2200/13 ,  C07F5/025

Abstract: The present invention provides fatty acid amide hydrolase inhibitors, solid forms thereof, compositions thereof, and methods of making and using the same.

Abstract translation: 本发明提供脂肪酸酰胺水解酶抑制剂，其固体形式，其组合物及其制备和使用方法。

公开(公告)号：WO2009086451A1

公开(公告)日：2009-07-09

申请号：PCT/US2008/088302

申请日：2008-12-24

Applicant: INFINITY PHARMACEUTICALS, INC. ,  AUSTAD, Brian, C.

Inventor： AUSTAD, Brian, C.

IPC: A01N43/42

CPC classification number: C07J7/009 ,  C07B2200/09 ,  C07D471/10 ,  C07D491/22 ,  C07J1/0011 ,  C07J5/0053 ,  C07J9/00 ,  C07J21/00 ,  C07J43/006 ,  C07J63/00 ,  C07J65/00 ,  C07J69/00 ,  C07J71/0005

Abstract: The invention is directed to a method to reduce a C-C double bond of an enone of a steroidal compound to produce a mixture of β ketone product and α ketone product, comprising treating a solution or suspension of the steroidal compound in a solvent with hydrogen gas in the presence of a catalyst and a substituted pyridine.

Abstract translation: 本发明涉及减少甾族化合物的烯酮的CC双键以产生β-酮产物和酮产物的混合物的方法，包括用甾醇中的氢气将甾类化合物在溶剂中的溶液或悬浮液 存在催化剂和取代的吡啶。

公开(公告)号：WO2012037217A1

公开(公告)日：2012-03-22

申请号：PCT/US2011/051553

申请日：2011-09-14

Applicant: INFINITY PHARMACEUTICALS, INC. ,  GENOV, Daniel, G. ,  AUSTAD, Brian, C. ,  WHITE, Brian, H.

Inventor： GENOV, Daniel, G. ,  AUSTAD, Brian, C. ,  WHITE, Brian, H.

IPC: A61K31/44 ,  B01J23/40

CPC classification number: C07D491/107 ,  B01J31/181 ,  B01J31/2428 ,  B01J2231/643 ,  B01J2531/821 ,  C07D491/048 ,  C07F17/02

Abstract: Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of Veratrum alkaloids, such as cyclopamine. Also provided herein are novel ruthenium transfer-hydrogenation catalysts.

Abstract translation: 本文提供了一种用于转化氢化Ver藜类生物碱成员的酮类似物的方法，例如环巴胺。 本文还提供了新的钌转移氢化催化剂。

公开(公告)号：WO2008073424A3

公开(公告)日：2008-06-19

申请号：PCT/US2007/025317

申请日：2007-12-11

Applicant: INFINITY DISCOVERY, INC. ,  AUSTAD, Brian, C. ,  GRENIER, Louis ,  HOLSON, Edward, B. ,  LEE, John, J. ,  PAK, Roger, H. ,  PORTER, James, R. ,  WRIGHT, James, L.

Inventor： AUSTAD, Brian, C. ,  GRENIER, Louis ,  HOLSON, Edward, B. ,  LEE, John, J. ,  PAK, Roger, H. ,  PORTER, James, R. ,  WRIGHT, James, L.

IPC: G01N21/25 ,  G01N33/52

Abstract: Provided herein, inter alia , are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 ("Hsp90").