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公开(公告)号:WO2017011837A2
公开(公告)日:2017-01-19
申请号:PCT/US2016/042862
申请日:2016-07-18
申请人: INHIBRX LP , TIMMER, John C. , JONES, Kyle S. , RAZAI, Amir S. , HUSSAIN, Abrahim , WILLIS, Katelyn M. , DEVERAUX, Quinn , ECKELMAN, Brendan P.
发明人: TIMMER, John C. , JONES, Kyle S. , RAZAI, Amir S. , HUSSAIN, Abrahim , WILLIS, Katelyn M. , DEVERAUX, Quinn , ECKELMAN, Brendan P.
IPC分类号: C07K16/28
CPC分类号: C07K16/2878 , A61K2039/505 , C07K2317/22 , C07K2317/24 , C07K2317/33 , C07K2317/35 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/75
摘要: The disclosure relates generally to molecules that specifically engage death receptor 5 (DR5), a member of the TNF receptor superfamily (TNFRSF). More specifically the disclosure relates to multivalent and multispecific molecules that bind at least DR5.
摘要翻译: 本公开通常涉及特异性地与TNF受体超家族(TNFRSF)的成员的死亡受体5(DR5)结合的分子。 更具体地,本公开涉及至少结合DR5的多价和多特异性分子。
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公开(公告)号:WO2017015623A2
公开(公告)日:2017-01-26
申请号:PCT/US2016/043717
申请日:2016-07-22
申请人: INHIBRX LP
发明人: TIMMER, John C. , JONES, Kyle S. , RAZAI, Amir S. , HUSSAIN, Abrahim , WILLIS, Katelyn M. , DEVERAUX, Quinn , ECKELMAN, Brendan P.
IPC分类号: A61K39/395 , C07K16/22
CPC分类号: C07K16/2878 , A61K2039/505 , C07K2317/21 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: This disclosure generally provides molecules that specifically engage glucocorticoid-induced TNFR-related protein (GITR), a member of the TNF receptor superfamily (TNFRSF). More specifically, the disclosure relates to multivalent and/or multispecific molecules that bind at least GITR.
摘要翻译: 本公开通常提供特异性参与糖皮质激素诱导的TNFR相关蛋白(GITR),TNF受体超家族(TNFRSF)的成员的分子。 更具体地,本公开涉及至少结合GITR的多价和/或多特异性分子。
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公开(公告)号:WO2017123673A3
公开(公告)日:2017-07-20
申请号:PCT/US2017/013070
申请日:2017-01-11
申请人: INHIBRX LP
发明人: ECKELMAN, Brendan P. , TIMMER, John C. , HATA, Chelsie , JONES, Kyle S. , HUSSAIN, Abrahim , RAZAI, Amir S. , BECKLUND, Bryan , PANDIT, Rajay , KAPLAN, Mike , RASON, Lucas , DEVERAUX, Quinn
IPC分类号: A61K38/16 , A61K39/395 , A61K45/06
摘要: This invention relates generally to molecules that specifically engage OX40, a member of the TNF receptor superfamily (TNFRSF). More specifically this invention relates to multivalent and multispecific molecules that bind at least OX40.
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公开(公告)号:WO2017123673A2
公开(公告)日:2017-07-20
申请号:PCT/US2017/013070
申请日:2017-01-11
申请人: INHIBRX LP
发明人: ECKELMAN, Brendan P. , TIMMER, John C. , HATA, Chelsie , JONES, Kyle S. , HUSSAIN, Abrahim , RAZAI, Amir S. , BECKLUND, Bryan , PANDIT, Rajay , KAPLAN, Mike , RASON, Lucas , DEVERAUX, Quinn
IPC分类号: C07K16/28
CPC分类号: C07K16/2878 , C07K16/2827 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/569 , C07K2317/75 , C07K2317/76 , C07K2319/00
摘要: This invention relates generally to molecules that specifically engage OX40, a member of the TNF receptor superfamily (TNFRSF). More specifically this invention relates to multivalent and multispecific molecules that bind at least OX40.
摘要翻译: 本发明一般涉及特异性结合TNF受体超家族(TNFRSF)成员OX40的分子。 更具体地说,本发明涉及结合至少OX40的多价和多特异性分子。 p>
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公开(公告)号:WO2017123650A3
公开(公告)日:2017-07-20
申请号:PCT/US2017/013040
申请日:2017-01-11
申请人: INHIBRX LP
发明人: ECKELMAN, Brendan P. , TIMMER, John C. , HATA, Chelsie , JONES, Kyle S. , HUSSAIN, Abrahim , RAZAI, Amir S. , BECKLUND, Bryan , PANDIT, Rajay , KAPLAN, Mike , RASON, Lucas , DEVERAUX, Quinn
IPC分类号: C07K16/28 , C07K14/705 , A61K39/395
摘要: This invention relates generally to molecules that specifically engage 41BB, a member of the TNF receptor superfamily (TNFRSF). More specifically, this invention relates to multivalent and multispecific molecules that bind at least 41BB.
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公开(公告)号:WO2017123650A2
公开(公告)日:2017-07-20
申请号:PCT/US2017/013040
申请日:2017-01-11
申请人: INHIBRX LP
发明人: ECKELMAN, Brendan P. , TIMMER, John C. , HATA, Chelsie , JONES, Kyle S. , HUSSAIN, Abrahim , RAZAI, Amir S. , BECKLUND, Bryan , PANDIT, Rajay , KAPLAN, Mike , RASON, Lucas , DEVERAUX, Quinn
IPC分类号: C07K16/28
CPC分类号: C07K16/2878 , C07K16/2827 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/569 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要: This invention relates generally to molecules that specifically engage 41BB, a member of the TNF receptor superfamily (TNFRSF). More specifically, this invention relates to multivalent and multispecific molecules that bind at least 41BB.
摘要翻译: 本发明一般涉及特异性结合TNF受体超家族(TNFRSF)成员41BB的分子。 更具体地说,本发明涉及结合至少41BB的多价和多特异性分子。 p>
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