公开(公告)号：WO2018075389A1

公开(公告)日：2018-04-26

申请号：PCT/US2017/056754

申请日：2017-10-16

Applicant: INNOBLATIVE DESIGNS, INC.

Inventor： RIOUX, Robert, F. ,  HASSE, Michelle ,  WANKE, Tyler

IPC: A61B18/00 ,  A61B18/14 ,  A61B18/08 ,  A61B18/10 ,  A61B18/12

Abstract: The present invention is directed to a medical device for providing treatment to diseased tissue and cells. The medical device is configured to ablate a target tissue surface, optionally within a resection cavity, and further deliver a therapeutic that targets diseased (e.g., cancer) cells via a marker whose expression is upregulated by the ablation. The ablation directly kills diseased cells associated with the tissue surface. While some diseased cells evade direct ablation, those cells nevertheless upregulate certain cell surface markers in response to the ablation, even while other, healthy or normal cells do not upregulate expression of the marker in response to the ablation. Devices and methods disclosed herein are used to deliver a therapeutic that uses the upregulated cell surface marker to cause the death of those diseased cells.

Abstract translation: 本发明涉及用于向患病组织和细胞提供治疗的医疗装置。 医疗装置被配置成消融目标组织表面，任选地在切除腔内，并且进一步递送治疗剂，该治疗剂通过表达被消融上调的标记物靶向患病（例如癌症）细胞。 消融直接杀死与组织表面相关的病变细胞。 虽然一些患病细胞逃避直接消融，但是那些细胞响应于消融而上调某些细胞表面标记，即使当其他健康或正常细胞不响应消融时也上调了标记的表达。 本文公开的装置和方法用于递送使用上调的细胞表面标志物引起那些患病细胞死亡的治疗剂。

公开(公告)号：WO2017151431A1

公开(公告)日：2017-09-08

申请号：PCT/US2017/019398

申请日：2017-02-24

Applicant: INNOBLATIVE DESIGNS, INC.

Inventor： RIOUX, Robert, F. ,  WANKE, Tyler ,  BEAN, Ryan, M. ,  HASSE, Michelle

IPC: A61B18/14

CPC classification number: A61B18/1402 ,  A61B2018/00029 ,  A61B2018/00083 ,  A61B2018/0016 ,  A61B2018/00529 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00601 ,  A61B2018/00607 ,  A61B2018/0063 ,  A61B2018/00654 ,  A61B2018/0072 ,  A61B2018/00755 ,  A61B2018/00767 ,  A61B2018/00875 ,  A61B2018/00958 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/144 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2218/002

Abstract: The invention generally relates to a tissue ablation system including an ablation device to be delivered to a target site and achieve both resection and coagulation of tissue. The ablation device can be used during an electrosurgical resection procedure to both resect tissue and further selectively coagulate surrounding tissue in the resection site so as to prevent or stop fluid accumulation (e.g., blood from vessel(s)) as a result of the resection of tissue.

Abstract translation: 本发明总体上涉及包括消融装置的组织消融系统，所述消融装置被递送到目标部位并实现组织的切除和凝固。 消融装置可以在电外科手术切除过程期间用于切除组织并且进一步选择性地凝固切除部位中的周围组织以便防止或阻止液体积聚（例如，血管从血管（一个或多个））作为切除 组织。

公开(公告)号：WO2017136262A1

公开(公告)日：2017-08-10

申请号：PCT/US2017/015584

申请日：2017-01-30

Applicant: INNOBLATIVE DESIGNS, INC.

Inventor： RIOUX, Robert, F. ,  BAILEY, Alyssa ,  BEAN, Ryan, M. ,  WANKE, Tyler ,  HASSE, Michelle

IPC: A61B18/10 ,  A61B18/12 ,  A61B18/14 ,  A61B18/18

CPC classification number: A61B18/1477 ,  A61B18/1206 ,  A61B18/148 ,  A61B18/1492 ,  A61B90/04 ,  A61B2017/00053 ,  A61B2017/00057 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/00333 ,  A61B2018/00577 ,  A61B2018/00648 ,  A61B2018/00708 ,  A61B2018/0072 ,  A61B2018/00726 ,  A61B2018/00744 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/00988 ,  A61B2018/124 ,  A61B2018/1417 ,  A61B2018/144 ,  A61B2090/0436 ,  A61B2218/002

Abstract: The invention is a tissue ablation system including an ablation device having an electrode array configured for the ablation of tissue, wherein the electrode array includes a plurality of conductive wires electrically isolated and independent from one another and configured to receive electrical current from a source and emit radiofrequency (RF) energy in response. The ablation system further includes a controller configured to control an emission pattern from the electrode array, either by independently controlling activation of one or more conductive wires or by actively blocking emission of energy from a selected one or more conductive wires or by adjusting flow of a conductive fluid for carrying RF energy emitted in a virtual electrode arrangement. Accordingly, the system provides a user with custom ablation shaping including custom, user-defined ablation geometries or profiles for RF emission in a desired shape or pattern so as to deliver targeted treatment to marginal tissue.

Abstract translation: 本发明是一种组织消融系统，包括消融装置，该消融装置具有被配置用于消融组织的电极阵列，其中该电极阵列包括多个导电线，该多个导电线彼此电隔离并且彼此独立并且被配置为 接收来自电源的电流并发出射频（RF）能量作为响应。 消融系统还包括控制器，该控制器被配置为通过独立地控制一个或多个导电线的激活或通过主动地阻止来自所选择的一个或多个导电线的能量发射或通过调节来自电极阵列的发射模式 导电流体，用于承载在虚拟电极布置中发射的RF能量。 因此，该系统为用户提供定制的消融成形，包括定制的，用户定义的消融几何形状或用于以期望的形状或图案的RF发射的轮廓，以便向边缘组织递送靶向治疗。