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1.发明申请A SCORING METHOD FOR PREDICTING THE EFFICIENCY OF A TREATMENT WITH ANTI-PD-1 AND/OR ANTI-PD-L1 MONOCLONAL ANTIBODIES 审中-公开用于预测抗PD-1和/或抗-PD-L1单克隆抗体治疗效率的评分方法
公开(公告)号：WO2017050855A1
公开(公告)日：2017-03-30
申请号：PCT/EP2016/072477
申请日：2016-09-21
发明人： GIRAULT, Isabelle , VAGNER, Stephan , ROBERT, Caroline , LANOY, Emilie , TEXIER, Matthieu , ADAM, Julien , SHEN, Shensi
IPC分类号： G01N33/574 , G06F19/00
CPC分类号： G01N33/574 , G01N2800/52 , G06F19/00 , G06F19/10 , G16H30/40 , G16H50/20 , G16H50/30
摘要： The invention aims at a method implemented by computer means (CC) for assessing an efficiency of a cure of a cancer disease based on at least one antibody against protein PD-1 and/or its ligand PD-L1, wherein the method comprises the steps: - Obtaining data of at least one microscope (MIC) image (IM DAT) of cells of a tumor material (TAM) treated for performing a test to assess an interaction between protein PD-1 and its ligand PD-L1 in at least some of said cells, - Counting in said image a number of spots related to said interactions between PD-1 and PD-L1, and a number of nuclei in said image, and - Estimating a ratio between said number of spots and said number of nuclei with a view to assess an efficiency of a cure based on at least one antibody against protein PD-1 and/or its ligand PD-L1 on a cancer disease from which said tumor material results.
摘要翻译： 本发明旨在通过计算机装置（CC）实施的方法，其基于至少一种针对蛋白质PD-1和/或其配体PD-L1的抗体来评估治愈癌症疾病的效率，其中该方法包括步骤 ： - 获得用于进行测试的至少一种显微镜（MIC）图像（IM DAT）的肿瘤材料（TAM）的细胞的数据，以评估至少一些蛋白质PD-1与其配体PD-L1之间的相互作用 - 在所述图像中计数与PD-1和PD-L1之间的所述相互作用相关的许多斑点以及所述图像中的多个核，以及 - 估计所述点数和所述核数之间的比率 以评估基于至少一种针对蛋白质PD-1和/或其配体PD-L1的抗体对所述肿瘤材料产生的癌症疾病的治疗效果。
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