专利检索 ap:("INSTITUTO DE MEDICINA MOLECULAR") AND inv:"ENGUITA, Francisco, Javier" 第 1 页

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发明申请
ANTI-MALARIAL COMPOUNDS 审中-公开

公开(公告)号：WO2022106892A1

公开(公告)日：2022-05-27

申请号：PCT/IB2021/000796

申请日：2021-11-17

申请人： INSTITUTO DE MEDICINA MOLECULAR

发明人： SETUA, Sonali , DIAS DA MOTA, Maria, Manuel , ENGUITA, Francisco, Javier , SUNDARAMURTHY, Varadharajan , RANGA-PRASAD, Harish

IPC分类号： A61K31/424 , A61K31/496 , A61P33/06

摘要： Disclosed herein are compositions and methods to prevent Plasmodium parasites from evading host cell autophagy responses, including by blocking binding of Plasmodium Upregulated in infective sporozoites 3 (UIS3) to host cell autophagy proteins, such as Microtubule-associated protein 1A/1 B-light chain 3 (LC3).