公开(公告)号：WO2016166550A1

公开(公告)日：2016-10-20

申请号：PCT/GB2016/051059

申请日：2016-04-15

申请人： ISIS INNOVATION LIMITED

发明人： TOWNLEY, Helen Elizabeth ,  BUSH, Rachel Anne

IPC分类号： A61L24/00 ,  A61L24/02 ,  A61L24/06 ,  A61K41/00

CPC分类号： A61K41/0038 ,  A61L24/001 ,  A61L24/02 ,  A61L2400/12 ,  A61L2430/36

摘要： The present invention relates to an embolization particle comprising a microparticle coated with a plurality of nanoparticles, which nanoparticles comprise a metal oxide doped with one or more rare earth elements, wherein the metal oxide is titanium dioxide, zinc oxide or cerium dioxide. An embolization particle of the invention for use in the treatment of cancer in combination with X-ray radiation or proton beam radiation, or use in embolization, is also described. The invention also relates to a process for producing an embolization particle comprising a microparticle coated with a plurality of nanoparticles, which nanoparticles comprise a metal oxide doped with one or more rare earth elements, wherein the metal oxide is titanium dioxide, zinc oxide or cerium dioxide, which process comprises: (i) providing a microparticle; (ii) contacting the microparticle with a plurality of the nanoparticles; and (iii) heating the microparticle and the nanoparticles to form the embolization particle.

摘要翻译： 本发明涉及包含涂覆有多个纳米颗粒的微粒的栓塞颗粒，该纳米颗粒包含掺杂有一种或多种稀土元素的金属氧化物，其中金属氧化物是二氧化钛，氧化锌或二氧化铈。 还描述了本发明的用于治疗癌症的结合X射线辐射或质子束辐射或用于栓塞的栓塞颗粒。 本发明还涉及一种用于生产包含涂覆有多个纳米颗粒的微粒的栓塞颗粒的方法，该纳米颗粒包含掺杂有一种或多种稀土元素的金属氧化物，其中金属氧化物是二氧化钛，氧化锌或二氧化铈 ，该方法包括：（i）提供微粒; （ii）使微粒与多个纳米粒子接触; 和（iii）加热微粒和纳米颗粒以形成栓塞颗粒。