公开(公告)号：WO1991014716A1

公开(公告)日：1991-10-03

申请号：PCT/US1991001455

申请日：1991-03-04

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  TAZI, Mohammed ,  LOGIN, Robert, B. ,  PLOCHOCKA, Krystyna ,  HALDAR, Rama, K. ,  GANGADHARAN, Balgopal ,  PROSISE, William, E.

IPC: C08F08/12

CPC classification number: C08F220/06 ,  A61K6/0026 ,  C08L33/08 ,  C08L33/10 ,  C08L35/08 ,  C08L1/08 ,  C08L39/06 ,  C08L31/04 ,  C08L1/28 ,  C08L89/04 ,  C08L5/04

Abstract: Slurry copolymerization of maleic anhydride with (meth)acrylic acid and, optionally, with C1-C4 alkyl vinyl ether in a cosolvent system of cyclohexane and ethyl acetate yields a pumpable slurry, from which uniform, fine, white powders having a predetermined weight average molecular weight of about 10,000 to one million, preferably about 30,000 to 400,000 are obtained. The copolymers are useful in a denture adhesive composition which is a mixed partial salt of the copolymer.

Abstract translation: 马来酸酐与（甲基）丙烯酸和任选地与C 1 -C 4烷基乙烯基醚在环己烷和乙酸乙酯的共溶剂体系中的淤浆共聚产生可泵送的浆料，从其中可以得到具有预定重均分子量的均匀的细的白色粉末 重量约10,000至100万，优选约30,000至400,000。 共聚物可用于义齿粘合剂组合物，其是共聚物的混合的部分盐。

公开(公告)号：WO1993021931A1

公开(公告)日：1993-11-11

申请号：PCT/US1993003835

申请日：1993-04-23

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  SHIH, Jenn, S. ,  MERIANOS, John, J. ,  SMITH, Terry, E. ,  CHUANG, Jui-Chang ,  HALDAR, Rama, K.

IPC: A61K31/79

CPC classification number: A01N59/00 ,  A01N59/12 ,  C08F8/00 ,  A01N25/10 ,  A01N2300/00 ,  C08F26/10

Abstract: Strongly swellable, moderately crosslinked polyvinylpyrrolidone polymer in the form of fine white powders having a defined aqueous gel volume and Brookfield viscosity which is prepared by precipitation polymerization in the presence of a prescribed amount of a crosslinking agent, and an effective amount of a pharmaceutical medicament, or hydrogen peroxide or iodine in the form of a complex, is described herein.

Abstract translation: 强溶胀性中等交联聚乙烯吡咯烷酮聚合物，其为具有限定水凝胶体积和布氏粘度形式的细白色粉末，其通过在规定量的交联剂存在下的沉淀聚合制备，以及有效量的药物， 或复合物形式的过氧化氢或碘。

公开(公告)号：WO1993009763A1

公开(公告)日：1993-05-27

申请号：PCT/US1992009821

申请日：1992-11-10

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  CHAUDHURI, Ratan, K. ,  JAISWAL, Dinesh, K. ,  HALDAR, Rama, K. ,  LOGIN, Robert, B. ,  TAZI, Mohammed ,  CHUANG, Jui-Chang

IPC: A61K09/14

CPC classification number: A61K9/2027

Abstract: A pharmaceutical tablet is provided herein having an effective dissolution rate. The tablet contains a pharmaceutically-active ingredient and a substantially linear, i.e. non-crosslinked K-30 to K-120 PVP, preferably above 116, as a binding agent. The PVP used herein preferably is made by a polymerization process in which the vinyl pyrrolidone monomer is polymerized in the presence of an initiator which produces a linear PVP polymerization, and a residual initiator level of less than 500 ppm.

Abstract translation: 本文提供了具有有效溶解速率的药片。 片剂含有药物活性成分和基本上线性的，即非交联的K-30至K-120 PVP，优选高于116，作为结合剂。 本文使用的PVP优选通过聚合方法制备，其中乙烯基吡咯烷酮单体在产生线性PVP聚合的引发剂存在下聚合，残余引发剂水平低于500ppm。

公开(公告)号：WO1992005221A1

公开(公告)日：1992-04-02

申请号：PCT/US1991004953

申请日：1991-07-12

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  CHAUDHURI, Ratan, K. ,  HALDAR, Rama, K. ,  GANGADHARAN, Balgopal

IPC: C08L39/00

CPC classification number: A61L24/06 ,  C08L35/00 ,  A61K6/0026 ,  C08L35/08 ,  C08L1/286 ,  C08L39/06 ,  C08L71/02

Abstract: This invention relates to superior bioadhesive compositions having time extended adhesive properties comprising a non-toxic carrier and a polymer having between about 45 and about 70 weight % of units having the structure (A). between about 50 and about 30 weight % of units having the structure (B). and/or (C). and 2 to 7 weight % of an amine salt containing a lactam functionality derived from A and/or B, wherein R is hydrogen, alkoxy, phenyl, carboxyl or -N lactam having from 3 to 6 carbon atoms; R1 is C1 to C6 alkylene and R2 is C2 to C4 alkylene; said copolymer having a number average molecular weight of about 40,000 to about 500,000 and a relatively small particle size. The invention also relates to the method of synthesizing and using the above composition.

公开(公告)号：WO1992001724A1

公开(公告)日：1992-02-06

申请号：PCT/US1991004004

申请日：1991-06-07

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  TAZI, Mohammed ,  LOGIN, Robert, B. ,  KWAK, Yoon, T. ,  GANGADHARAN, Balgopal ,  HALDAR, Rama, K. ,  PLOCHOCKA, Krystyna ,  RIZZO, Thomas

IPC: C08F222/04

CPC classification number: A61K8/8164 ,  A61K6/0026 ,  A61Q5/06 ,  C08F222/06 ,  C08L35/08 ,  C08L1/02 ,  C08L1/286 ,  C08L33/10 ,  C08L39/06 ,  C08L31/04 ,  C08L89/04 ,  C08L5/04 ,  C08L71/02

Abstract: Terpolymers of maleic anhydride, a C1-C5 alkyl vinyl ether and isobutylene or a C12-C14 alpha-olefin, and crosslinked products thereof, are provided herein for use in thickener, denture adhesive, sunscreen, hair spray, and waterproofing compositions. The alpha-olefin comonomer is a hydrophobic, straight chain, unsaturated hydrocarbon such as dodecene or tetradecene, which is present in the terpolymer in predetermined amounts relative to the hydrophilic maleic anhydride component, to provide a terpolymer having a suitable HLB for these applications. The isobutylene comonomer provides hydrophilic terpolymer compositions which are particularly useful as denture adhesives.

Abstract translation: 本文提供马来酸酐，C1-C5烷基乙烯基醚和异丁烯或C 12 -C 14α-烯烃的三元共聚物及其交联产物，用于增稠剂，义齿粘合剂，防晒剂，喷发剂和防水组合物中。 α-烯烃共聚单体是一种疏水的直链不饱和烃，如十二碳烯或十四碳烯，其相对于亲水性马来酸酐组分以预定量存在于三元共聚物中，以提供具有适用于这些用途的合适HLB的三元共聚物。 异丁烯共聚单体提供亲水性三元共聚物组合物，其特别用作义齿粘合剂。