公开(公告)号：WO2022024024A2

公开(公告)日：2022-02-03

申请号：PCT/IB2021/056909

申请日：2021-07-29

申请人： JANSSEN BIOTECH, INC.

发明人： OBERMAJER, Natasa ,  ZWOLAK, Adam ,  LAQUERRE, Sylvie ,  BREHMER, Dirk ,  DE LANGE, Desiree ,  HÄSLER, Julien ,  VERSMISSEN, Shana ,  PETLEY, Theodore D. ,  VAN DE VEN, Kelly ,  YI, Fang ,  SINGH, Sanjaya

IPC分类号： A61K39/395 ,  C07K16/46 ,  C07K16/28 ,  A61P35/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/545 ,  A61K39/39558 ,  C07K16/2809 ,  C07K16/2833 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73

摘要： The invention provides antigen binding domains that bind human leukocyte antigen G (HLA-G) protein comprising the antigen binding domains that bind HLA-G, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：WO2021240388A1

公开(公告)日：2021-12-02

申请号：PCT/IB2021/054582

申请日：2021-05-26

申请人： JANSSEN BIOTECH, INC.

发明人： LUO, Jinquan ,  BRITTINGHAM, Raymond ,  YI, Fang ,  BRODEUR, Scott R. ,  GANESAN, Rajkumar ,  HOOVER, Jaclyn ,  JACOBS, Steven A. ,  KANE, Colleen M. ,  SINGH, Sanjaya ,  ZWOLAK, Adam ,  BHATT, Triveni K. ,  FELDKAMP, Michael Dennis ,  LAPORTE, Sherry Lynn

IPC分类号： A61P35/00 ,  C07K16/28 ,  C07K16/46 ,  A61K39/395

摘要： The disclosure provides antigen binding domains that bind cluster of differentiation 3 (CD3) protein, comprising the antigen binding domains that bind CD3ε, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：WO2021019386A1

公开(公告)日：2021-02-04

申请号：PCT/IB2020/056966

申请日：2020-07-23

申请人： JANSSEN BIOTECH, INC.

发明人： BRITTINGHAM, Raymond ,  GANESAN, Rajkumar ,  LA PORTE, Sherry ,  LEE, John ,  LUO, Jinquan ,  MCDEVITT, Theresa ,  SHEN, Fei ,  SINGH, Sanjaya ,  SONG, Degang ,  VENKATARAMANI, Sathyadevi ,  YI, Fang ,  ZHAO, Yonghong

IPC分类号： C07K16/30 ,  C07K16/40 ,  A61K39/00 ,  C07K14/725

摘要： The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

公开(公告)号：WO2022201053A1

公开(公告)日：2022-09-29

申请号：PCT/IB2022/052646

申请日：2022-03-23

申请人： JANSSEN BIOTECH, INC.

发明人： ZWOLAK, Adam ,  BRITTINGHAM, Raymond ,  BRODEUR, Scott R. ,  GANESAN, Rajkumar ,  LA PORTE, Sherry Lynn ,  LUO, Jinquan ,  YI, Fang ,  KANE, Colleen M. ,  BHATT, Triveni K.

IPC分类号： C07K16/28 ,  C07K16/30 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2878 ,  C07K16/2887 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/60 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94

摘要： The disclosure provides antigen binding domains that bind cluster of differentiation 3 (CD3) protein, comprising the antigen binding domains that bind CD3ε, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：WO2021019389A1

公开(公告)日：2021-02-04

申请号：PCT/IB2020/056972

申请日：2020-07-23

申请人： JANSSEN BIOTECH, INC.

发明人： GANESAN, Rajkumar ,  LEE, John ,  LUO, Jinquan ,  MCDEVITT, Theresa ,  SHEN, Fei ,  SONG, Degang ,  BRITTINGHAM, Raymond ,  VENKATARAMANI, Sathyadevi ,  SINGH, Sanjaya ,  ZHAO, Yonghong ,  YI, Fang ,  LA PORTE, Sherry Lynn

IPC分类号： C07K16/40 ,  C07K16/28 ,  A61K47/68 ,  A61K39/00 ,  C07K14/725 ,  C07K16/30

摘要： Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.