公开(公告)号：WO2022175255A2

公开(公告)日：2022-08-25

申请号：PCT/EP2022/053651

申请日：2022-02-15

申请人： JANSSEN PHARMACEUTICA NV

发明人： ATTAR, Ricardo Marcos ,  BRODEUR, Scott Ronald ,  GANESAN, Rajkumar ,  LUISTRO, Leopoldo ,  PHILIPPAR, Ulrike ,  PILLARISETTI, Kodandaram ,  JINGH, Sanjaya ,  YANG, Danlin Dan Qing

IPC分类号： A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  A61K2039/505 ,  A61K2039/545 ,  C07K14/7051 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： Provided herein are multispecific antibodies that bind to BCMA, GPRC5D and CD3 and multispecific antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided multispecific antibodies or multispecific antigen-binding fragments, cells expressing the provided multi specific antibodies or multispecific antigen-binding fragments, as well as associated vectors and detectably labeled multispecific antibodies or multispecific antigen-binding fragments. In addition, methods of producing and using the provided multispecific antibodies and multispecific antigen-binding fragments are described. Further provided herein are antibodies that bind to BCMA and antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided BCMA-specific antibodies or antigen- binding fragments, cells expressing the provided BCMA-specific antibodies or antigen- binding fragments, as well as associated vectors and detectably labeled BCMA-specific antibodies or antigen-binding fragments. In addition, methods of producing and using the provided BCMA-specific antibodies and antigen-binding fragments are described.