公开(公告)号：WO2022269013A1

公开(公告)日：2022-12-29

申请号：PCT/EP2022/067290

申请日：2022-06-23

申请人： JOHANN WOLFGANG GOETHE-UNIVERSITÄT FRANKFURT

发明人： KIPPENBERGER, Stefan ,  STEINHORST, Katja ,  CINATL, Jindrich ,  BOJKOVA, Denisa ,  KÖNIG, Veronika ,  KLEEMANN, Johannes

IPC分类号： C12N15/113 ,  A61K31/7125 ,  C12N15/115 ,  C12N15/1131 ,  C12N2310/18 ,  C12N2310/315 ,  C12N2310/531

摘要： The invention relates to an oligonucleotide molecule having from 10 to 50 nucleotides comprising at least one G-quartet forming motif comprising 10 to 20 nucleotide residues, wherein at least 60% of said G-quartet forming motive forming residues are guanosine or deoxyguanosine residues, and wherein the molecule inhibits tumor growth and/or viral or bacterial replication and/or exerts anti-inflammatory effects in mammalian cells.