公开(公告)号：WO2018015364A1

公开(公告)日：2018-01-25

申请号：PCT/EP2017/068085

申请日：2017-07-18

Applicant: JOINTHERAPEUTICS S.R.L.

Inventor： MORPURGO, Margherita ,  BIANCHINI, Giulio ,  CALLEGARO, Lanfranco

IPC: A61K9/08 ,  A61K47/36 ,  A61K31/196 ,  A61K31/58 ,  A61P19/02 ,  A61K47/69

Abstract: The present application describes compositions that can be used for the controlled release of pharmacological active ingredients from a viscoelastic aqueous polysaccharide matrix, and their potential use in the treatment of different stages of musculoskeletal diseases. The combination of drug release modulation and the viscoelastic nature of the composition makes possible the use thereof in the treatment of acute and chronic phases of musculoskeletal diseases characterized by an inflammatory state, and where a therapeutic effect and a viscosupplemental contribution are required.

Abstract translation: 本申请描述了可用于从粘弹性含水多糖基质中控制释放药理学活性成分的组合物，以及它们在治疗肌肉骨骼疾病的不同阶段中的潜在用途。 药物释放调节和组合物的粘弹性性质的组合使得其可用于治疗以炎症状态为特征的肌肉骨骼疾病的急性和慢性阶段，并且其中需要治疗效果和粘性补充作用。

公开(公告)号：WO2017211776A1

公开(公告)日：2017-12-14

申请号：PCT/EP2017/063639

申请日：2017-06-06

Applicant: JOINTHERAPEUTICS S.R.L.

Inventor： CALLEGARO, Lanfranco ,  BRUN, Paola ,  BIANCHINI, Giulio

IPC: A61K31/722 ,  A61K31/728 ,  A61P17/02 ,  A61P17/12 ,  A61P19/00 ,  A61P19/02 ,  A61P19/04

Abstract: The present application describes polysaccharide compositions that can be used as modulators of cell proliferation processes and their use in tissue repair with fibrotic process inhibition. These modulation properties can be usefully used in tissue repair for the prevention of fibrotic processes and/or tissue adhesions in traumatic, post-surgical and chronic fibrotic processes associated to autoimmune diseases.

Abstract translation: 本申请描述了可用作细胞增殖过程的调节剂的多糖组合物及其在纤维化过程抑制的组织修复中的用途。 这些调节特性可用于组织修复中，用于预防与自身免疫性疾病相关的创伤性，手术后和慢性纤维化过程中的纤维化过程和/或组织粘连。