公开(公告)号：WO2016110869A4

公开(公告)日：2016-10-27

申请号：PCT/IN2016000004

申请日：2016-01-04

Applicant: JOSHI VISHWAS DATTATRAYA

Inventor： JOSHI VISHWAS DATTATRAYA ,  MURTHY U M SREENIVASA ,  RANE SHAILENDRA DEVICHARAN ,  NADE MANASI SANJAY

IPC: C12N15/45 ,  C12N7/01

CPC classification number: C12N15/86 ,  C12N2760/18432 ,  C12N2760/18443 ,  C12N2770/24123 ,  C12N2770/24134 ,  C12N2840/20

Abstract: This invention comprises: compositions comprising a derivative, plasmids, a reagent kit and methods of making these compositions a derivative, vaccine- and non-vacicine-compositions of above for causing death of cancer cells that form part of a tunoour and virus infected Denguue, Measles and other diseased cells; the derivative comprising replicating as well as non-replicating dervivaties of an attenuated negative stranded RNA virus belonging to family paramyxoviridae, including Measles Virus, comprising a single additional transcriptional unit carrying either only one or two or more non-viral genes, and the non-replicating derivatives being free from contaminating replicating Measles Virus (b) a Measles Virus packaging cell line for making above compositions, expressing the M, F and H proteins of MV stably. And (c) a reagent kit for producing the Measles Virus derivatives describved above.

Abstract translation: 本发明包括：包含衍生物，质粒，试剂盒的组合物和制备这些组合物的上述衍生物，疫苗和非疫苗组合物的方法，所述组合物用于引起形成呼吸道和病毒感染Denguue的一部分的癌细胞死亡， 麻疹和其他病变细胞; 所述衍生物包含属于副粘病毒科（包括麻疹病毒）的减毒负链RNA病毒的复制以及非复制性衍生病毒，其包含仅携带一种或两种或更多种非病毒基因的单一额外转录单元， （b）用于制备上述组合物的麻疹病毒包装细胞系，稳定地表达MV的M，F和H蛋白。 （c）用于产生上述麻疹病毒衍生物的试剂盒。

公开(公告)号：WO2016110869A3

公开(公告)日：2016-10-06

申请号：PCT/IN2016000004

申请日：2016-01-04

Applicant: JOSHI VISHWAS DATTATRAYA

Inventor： JOSHI VISHWAS DATTATRAYA ,  MURTHY U M SREENIVASA ,  RANE SHAILENDRA DEVICHARAN ,  NADE MANASI SANJAY

IPC: C12N15/45 ,  C12N7/01

CPC classification number: C12N15/86 ,  C12N2760/18432 ,  C12N2760/18443 ,  C12N2770/24123 ,  C12N2770/24134 ,  C12N2840/20

Abstract: This invention comprises: compositions comprising a derivative, plasmids, a reagent kit and methods of making these compositions a derivative, vaccine- and non-vacicine-compositions of above for causing death of cancer cells that form part of a tunoour and virus infected Denguue, Measles and other diseased cells; the derivative comprising replicating as well as non-replicating dervivaties of an attenuated negative stranded RNA virus belonging to family paramyxoviridae, including Measles Virus, comprising a single additional transcriptional unit carrying either only one or two or more non-viral genes, and the non-replicating derivatives being free from contaminating replicating Measles Virus (b) a Measles Virus packaging cell line for making above compositions, expressing the M, F and H proteins of MV stably. And (c) a reagent kit for producing the Measles Virus derivatives describved above.

Abstract translation: 本发明包括：包含衍生物，质粒，试剂盒的组合物和制备这些组合物的方法，所述组合物是导致癌细胞死亡的衍生物，疫苗和非疫苗组合物，所述癌细胞形成呼吸道和病毒感染的登革热的一部分， 麻疹等病变细胞; 所述衍生物包含属于副粘病毒科（包括麻疹病毒）的减毒负链RNA病毒的复制和非复制衍生物，其包含携带仅一个或两个或多个非病毒基因的单个另外的转录单位， 复制的衍生物没有污染复制的麻疹病毒（b）用于制备上述组合物的麻疹病毒包装细胞系，稳定地表达MV的M，F和H蛋白。 和（c）用于生产上述麻疹病毒衍生物的试剂盒。