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    DNA MOLECULES PRODUCING CUSTOM DESIGNED REPLICATING AND NON-REPLICATING NEGATIVE STRANDED RNA VIRUSES AND USES THERE OF
    2.
    发明申请
    DNA MOLECULES PRODUCING CUSTOM DESIGNED REPLICATING AND NON-REPLICATING NEGATIVE STRANDED RNA VIRUSES AND USES THERE OF 审中-公开
    生产定制设计的复制和不复制负链RNA病毒的DNA分子及其用途

    公开(公告)号：WO2016110869A2

    公开(公告)日：2016-07-14

    申请号：PCT/IN2016/000004

    申请日：2016-01-04

    Applicant: JOSHI, Vishwas Dattatraya

    Inventor： JOSHI, Vishwas Dattatraya ,  MURTHY, U.M. Sreenivasa ,  RANE, Shailendra Devicharan ,  NADE, Manasi Sanjay

    IPC: C12N15/45

    CPC classification number: C12N15/86 ,  C12N2760/18432 ,  C12N2760/18443 ,  C12N2770/24123 ,  C12N2770/24134 ,  C12N2840/20

    Abstract: This invention comprises: compositions comprising a derivative, plasmids, a reagent kit and methods of making these compositions a derivative, vaccine- and non-vacicine-compositions of above for causing death of cancer cells that form part of a tunoour and virus infected Denguue, Measles and other diseased cells; the derivative comprising replicating as well as non-replicating dervivaties of an attenuated negative stranded RNA virus belonging to family paramyxoviridae, including Measles Virus, comprising a single additional transcriptional unit carrying either only one or two or more non-viral genes, and the non-replicating derivatives being free from contaminating replicating Measles Virus (b) a Measles Virus packaging cell line for making above compositions, expressing the M, F and H proteins of MV stably. And (c) a reagent kit for producing the Measles Virus derivatives describved above.

    Abstract translation: 本发明包括：包含衍生物，质粒，试剂盒的组合物以及使这些组合物成为上述用于引起癌细胞死亡的上述衍生物，疫苗和非疫苗组合物的方法 感染登革热，麻疹和其他病变细胞的病毒和病毒; 所述衍生物包含属于副粘病毒科（包括麻疹病毒）的减毒负链RNA病毒的复制以及非复制性衍生病毒，其包含仅携带一种或两种或更多种非病毒基因的单一额外转录单元， （b）用于制备上述组合物的麻疹病毒包装细胞系，稳定地表达MV的M，F和H蛋白。 （c）用于产生上述麻疹病毒衍生物的试剂盒。

    A NOVEL PARAMYXOVIRUS AND USES THEREOF
    3.
    发明申请
    A NOVEL PARAMYXOVIRUS AND USES THEREOF 审中-公开
    一种新的寄生虫病毒及其用途

    公开(公告)号：WO2013107290A1

    公开(公告)日：2013-07-25

    申请号：PCT/CN2013/000060

    申请日：2013-01-21

    Applicant: THE GOVERNMENT OF THE HONG KONG SPECIAL ADMINISTRATIVE REGION OF THE PEOPLE'S REPUBLIC OF CHINA ,  VERSITECH LIMITED

    Inventor： YUEN, Kwok Yung ,  WOO, Chiu Yat, Patrick ,  LAU, Kar Pui, Susanna

    IPC: C12N15/45 ,  C07K14/12 ,  C12N15/86 ,  C12N5/16 ,  C07K16/10 ,  C12Q1/68 ,  A61K39/155 ,  A61P31/14

    CPC classification number: C07K14/115 ,  A61K39/12 ,  A61K2039/55566 ,  C07K14/005 ,  C07K16/1027 ,  C07K2317/76 ,  C12N7/00 ,  C12N2760/18421 ,  C12N2760/18422 ,  C12N2760/18434 ,  C12Q1/701 ,  G01N33/6893

    Abstract: An isolated paramyxovirus, a morbillivirus (FmoPV), isolated nucleic acids encoding the genome of FmoPV, isolated amino acid sequences of FmoPV protein, antibodies to FmoPV and its proteins, and uses thereof are provided. In certain embodiments, the modified FmoPV is a feline morbillivirus. A recombinant FmoPV comprising a modified FmoPV gene or gene segments and the use of such virus are provided. The recombinant FmoPV may be used in the prevention and/or treatment of diseases related to FmoPV or as a delivery vector. A diagnostic assay for the FmoPV is provided. In certain embodiments, the FmoPV causes kidney disease. In certain embodiments, the kidney disease is in felines. In certain embodiments, the kidney disease is tubulo interstitial nephritis ("TIN"). A quantitative assay for the detection of the FmoPV, natural or artificial variants, analogs, or derivatives thereof is provided. In certain embodiments, the quantitative assay is reverse transcription and polymerase chain reaction (RT-PCR). A vaccine and a kit containing the vaccine for the prevention and treatment of FmoPV infection are provided. A diagnosis kit that comprises nucleic acid molecules for the detection of the FmoPV is also provided.

    Abstract translation: 提供了分离的副粘病毒，病毒病毒（FmoPV），编码FmoPV基因组的分离的核酸，FmoPV蛋白的分离的氨基酸序列，FmoPV及其蛋白质的抗体及其用途。 在某些实施方案中，修饰的FmoPV是猫状病毒病毒。 提供了包含修饰的FmoPV基因或基因片段的重组FmoPV以及这种病毒的用途。 重组FmoPV可用于预防和/或治疗与FmoPV相关的疾病或作为递送载体。 提供了FmoPV的诊断测定。 在某些实施方案中，FmoPV引起肾脏疾病。 在某些实施方案中，肾脏疾病在猫科动物中。 在某些实施方案中，肾脏疾病是肾小管间质性肾炎（“TIN”）。 提供了用于检测FmoPV，天然或人造变体，类似物或衍生物的定量测定。 在某些实施方案中，定量测定法是逆转录和聚合酶链反应（RT-PCR）。 提供了一种疫苗和含有预防和治疗FmoPV感染疫苗的试剂盒。 还提供了包含用于检测FmoPV的核酸分子的诊断试剂盒。

    RECOMBINANT VIRUSES WITH HETEROLOGOUS ENVELOPE PROTEINS
    10.
    发明申请
    RECOMBINANT VIRUSES WITH HETEROLOGOUS ENVELOPE PROTEINS 审中-公开
    重组病毒与外源性包膜蛋白

    公开(公告)号：WO2005080417A3

    公开(公告)日：2006-06-29

    申请号：PCT/US2004041067

    申请日：2004-12-10

    Applicant: UAB RESEARCH FOUNDATION ,  OOMENS ANTONIUS G P ,  WERTZ GAIL W ,  MEGAW ALEXANDER GEORGE

    Inventor： OOMENS ANTONIUS G P ,  WERTZ GAIL W ,  MEGAW ALEXANDER GEORGE

    IPC: A61K39/155 ,  C07K14/01 ,  C07K14/115 ,  C07K14/135 ,  C12N7/04 ,  C12N15/34 ,  C12N15/45 ,  C12N15/62 ,  C12N15/86 ,  G01N33/50

    CPC classification number: C12N15/86 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C07K2319/00 ,  C12N7/00 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18543 ,  C12N2760/18545 ,  C12N2760/18562 ,  C12N2810/60

    Abstract: The invention provides recombinant viruses comprising heterologous envelope proteins capable of mediating entry of the recombinant viruses into host cells. In one embodiment, a recombinant virus of the invention is a member of the Paramyxovirzdae family (e.g., a respiratory syncytial virus), and the heterologous envelope protein includes the ectodomain of a baculovirus envelope protein (e.g., the GP64 protein). In some cases, the heterologous envelope protein is provided in addition to homologous envelope proteins) which may or may not be functional. The heterologous protein can provide the recombinant virus with enhanced stability (e.g., at 4 °C, 22 °C, or 37 °C), and allows production of high-titer virus stocks. The heterologous protein can also impart temperature sensitivity to the replication of the recombinant virus. In addition, the recombinant virus can be designed to be infectious but incapable of spreading between host cells by providing the heterologous protein by complementation in trans. These features attenuate the disease-causing potential of the recombinant virus, therefore increasing its safety of use as vaccines.

    Abstract translation: 本发明提供了包含能够介导重组病毒进入宿主细胞的异源包膜蛋白的重组病毒。 在一个实施方案中，本发明的重组病毒是副粘病毒科（例如呼吸道合胞病毒）的成员，异源包膜蛋白包括杆状病毒包膜蛋白（例如GP64蛋白）的胞外域。 在一些情况下，异源包膜蛋白除了同源包膜蛋白外还提供），其可以是或不是功能性的。 异源蛋白质可以提供具有增强的稳定性（例如在4℃，22℃或37℃）的重组病毒，并且允许产生高滴度病毒种群。 异源蛋白质还可以赋予重组病毒复制的温度敏感性。 此外，重组病毒可被设计为感染性的，但不能通过在反式中互补提供异源蛋白质而在宿主细胞之间扩散。 这些特征减轻重组病毒的致病潜力，从而增加其作为疫苗使用的安全性。

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