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公开(公告)号：WO2013055058A3
公开(公告)日：2013-08-01
申请号：PCT/KR2012007993
申请日：2012-10-02
发明人： CHUNG SANG JEON , KANG SE BYUNG , KANG HYO JIN , KANG YOUNG JI , LEE YOUNG MI
IPC分类号： A61K38/00 , A61K9/16 , A61K39/395 , A61K47/48
CPC分类号： A61K49/1818 , A61K38/00 , C07K14/47 , C07K2319/00
摘要： The present invention relates to nanoparticles including 24 antibody-binding peptide-ferritin fusion protein monomers, the nanoparticles being characterized in that six partial structures having a 4-fold symmetry point are formed due to ferritin, and an antibody-binding peptide is fused to the ferritin in a range of ±10 a.a. of the 4-fold symmetry point such that 4 antibody-binding peptides are positioned in the vicinity of the 4-fold symmetry point; and also relates to uses of the nanoparticles. The present invention can be used for biochips, drug delivery systems, disorder diagnosis, and the development of treating agents by producing the fusion protein through the introduction of the sequence of the antibody-binding peptide into the ferritin, and using the fusion protein to allow the antibody to strongly bind to the ferritin without any damage to the antibody structure.
摘要翻译： 本发明涉及包含24种抗体结合肽 - 铁蛋白融合蛋白单体的纳米颗粒，该纳米粒子的特征在于由于铁蛋白形成了具有4倍对称点的6个部分结构，并且抗体结合肽与 铁蛋白在±10 aa范围内 的4倍对称点，使得4个抗体结合肽位于4倍对称点附近; 并且还涉及纳米颗粒的用途。 通过将抗体结合肽的序列引入铁蛋白中，本发明可以用于生物芯片，药物递送系统，病症诊断和治疗剂的开发，并且使用融合蛋白允许 所述抗体强烈结合铁蛋白而不会对抗体结构造成任何损伤。
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公开(公告)号：WO2013055058A2
公开(公告)日：2013-04-18
申请号：PCT/KR2012007993
申请日：2012-10-02
发明人： CHUNG SANG JEON , KANG SE BYUNG , KANG HYO JIN , KANG YOUNG JI , LEE YOUNG MI
IPC分类号： A61K38/00 , A61K9/16 , A61K39/395 , A61K47/48
CPC分类号： A61K49/1818 , A61K38/00 , C07K14/47 , C07K2319/00
摘要： The present invention relates to nanoparticles including 24 antibody-binding peptide-ferritin fusion protein monomers, the nanoparticles being characterized in that six partial structures having a 4-fold symmetry point are formed due to ferritin, and an antibody-binding peptide is fused to the ferritin in a range of ±10 a.a. of the 4-fold symmetry point such that 4 antibody-binding peptides are positioned in the vicinity of the 4-fold symmetry point; and also relates to uses of the nanoparticles. The present invention can be used for biochips, drug delivery systems, disorder diagnosis, and the development of treating agents by producing the fusion protein through the introduction of the sequence of the antibody-binding peptide into the ferritin, and using the fusion protein to allow the antibody to strongly bind to the ferritin without any damage to the antibody structure.
摘要翻译： 本发明涉及包含24个抗体结合性肽 - 铁蛋白融合蛋白单体的纳米颗粒，所述纳米颗粒的特征在于由于铁蛋白而形成了具有4重对称点的六个部分结构，并且抗体结合肽与 铁蛋白在±10 aa的范围内 的4倍对称点，使得4个抗体结合肽位于4倍对称点附近; 并且还涉及纳米颗粒的用途。 本发明可以通过将抗体结合性肽的序列导入铁蛋白制作融合蛋白，使用该融合蛋白使其可以用于生物芯片，给药系统，障碍诊断，治疗药物的开发等 抗体与铁蛋白强烈结合而对抗体结构没有任何损害。
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