公开(公告)号：WO2019122882A1

公开(公告)日：2019-06-27

申请号：PCT/GB2018/053698

申请日：2018-12-19

申请人： KYMAB LIMITED

发明人： MCCOURT, Matthew John ,  SAINSON, Richard Charles Alfred ,  CAMPBELL, Jamie Iain ,  ARKINSTALL, Stephen John ,  TUNA, Mihriban ,  FIEHLER, Ryan ,  FAROUDI, Mustapha ,  BADR, Fadi ,  WOLLERTON VAN HORCK, Francisca ,  AKELE, Frederik

IPC分类号： C07K16/28 ,  A61P35/00

CPC分类号： C07K16/2827 ,  A61K2039/505 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/2818 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/526 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2319/00

摘要： Multispecific antibody in mAb2 format, comprising an ICOS-binding Fab region and a PD-L1-binding Fcab region. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours. Combination therapy including antibody to another immune checkpoint molecule such as PD-1 and CTLA-4, in addition to anti-ICOS and anti-PD-L1.