公开(公告)号：WO2009066969A1

公开(公告)日：2009-05-28

申请号：PCT/LV2008/000002

申请日：2008-05-15

Applicant: LATVIJAS UNIVERSITATE ,  SOMTA, SIA ,  Z-LIGHT, SIA ,  SPIGULIS, Janis

Inventor： SPIGULIS, Janis

IPC: G02B6/26 ,  G02B6/255

CPC classification number: G02B6/262 ,  G02B6/2552

Abstract: The invention relates to fibre optics, particularly to the optical signal transmission through the end of optical fibre orthogonally to its symmetry axis, and can be applied in illumination engineering, phototherapy, fibre-optical endoscopy, laser surgery, optical tomography, optical instrument engineering and in other fields. The proposed side emitting/detecting optical fibre with total internal reflection surface sloped to the fibre axis and output/input plane parallel to the fibre axis is characterized in that the reflecting surface and the output/input plane are optically monolithically integrated at the end of optical fibre core by filling the space between the output/input plane and cylindrical lateral surface of the core in front of the reflective surface with material of the fibre core or with similar optically transparent material, at that the distance of the output/input plane from the fibre axis is equal or exceeds external radius of the fibre. The proposed configuration provides several technical advantages, particularly, smaller size (which is more convenient in use and reduces the optical material consumption), shorter light pass from/to the fibre core (which assures more precise localisation of the emitted/detected radiation at the contact surface, as well as enhanced radiation collection efficiency), solid optical assembly (which excludes radiation refraction during its deflection, minimizes optical losses and assures more safe operation), as well as makes possible to obtain qualitative optical contact with a planar surface, oriented parallel to the fibre axis, without any additional components.

Abstract translation: 本发明涉及光纤，特别涉及通过光纤端面与其对称轴正交的光信号传输，并且可应用于照明工程，光疗法，光纤内窥镜检查，激光手术，光学层析成像，光学仪器工程和 在其他领域。 所提出的侧面发射/检测光纤具有向纤维轴倾斜的全内反射面和平行于光纤轴的输出/输入平面，其特征在于反射表面和输出/输入平面在光学端部光学地单片集成 通过用光纤芯材料或类似的光学透明材料填充反射表面前面的芯的输出/输入平面和圆柱形侧表面之间的空间，从而输出/输入平面与 纤维轴等于或超过纤维的外半径。 所提出的配置提供了几个技术优点，特别是较小的尺寸（其在使用中更方便并且减少光学材料消耗），从/到纤维芯的更短的光通过（这确保了发射/检测的辐射在 接触表面，以及增强的辐射收集效率），固体光学组件（其在偏转期间不包括辐射折射，使光损耗最小化并确保更安全的操作），并且使得可以获得与平面表面定向的光学接触 平行于纤维轴线，没有任何附加部件。

公开(公告)号：WO2017012675A1

公开(公告)日：2017-01-26

申请号：PCT/EP2015/066913

申请日：2015-07-23

Applicant: LATVIJAS UNIVERSITATE

Inventor： SPIGULIS, Janis ,  LACIS, Matiss ,  KUZMINA, Ilona ,  LIHACOVS, Aleksejs ,  RUPENHEITS, Zigmars ,  UPMALIS, Vladimirs

IPC: A61B5/00

CPC classification number: A61B5/0071 ,  A61B5/0075 ,  A61B5/14552 ,  A61B5/14556 ,  A61B5/441 ,  A61B5/443 ,  A61B5/6898

Abstract: The invention relates to imaging technologies, in particular to remote imaging of tissue chromophore and/or fluorophore distribution by means of a smartphone or a similar mobile device. Goal of the invention is to ensure easy use of smartphones (or similar mobile devices, originally comprising at least one camera, display, processing unit and battery) with appropriate software for remote mapping of tissue compounds. Invention proposes tissue chromophore and/or fluorophore mapping and/or indication of clinically critical values of their content on the display of smartphone by converting images of the same tissue area taken by smartphone camera under spectrally specific illumination and using the internal computing resources of smartphone for image processing. Five supporting device designs are proposed along with two methods used for image processing.

Abstract translation: 本发明涉及成像技术，特别涉及通过智能手机或类似的移动设备远程成像组织发色团和/或荧光团分布。 本发明的目标是确保容易地使用具有用于组织化合物的远程映射的适当软件的智能电话（或者类似的移动设备，最初包括至少一个摄像机，显示器，处理单元和电池）。 本发明通过在光谱特异性照明下转换由智能相机拍摄的相同组织区域的图像并使用智能手机的内部计算资源来提出组织发色团和/或荧光团映射和/或其在智能手机显示器上的内容临床临界值的指示， 图像处理。 提出了五种支持装置设计以及用于图像处理的两种方法。

公开(公告)号：WO2018177565A1

公开(公告)日：2018-10-04

申请号：PCT/EP2017/063565

申请日：2017-06-02

Applicant: LATVIJAS UNIVERSITATE

Inventor： RUBINS, Uldis ,  KVIESIS-KIPGE, Edgars ,  SPIGULIS, Janis

IPC: G01J3/10 ,  G02B27/48 ,  G02B21/08

CPC classification number: G02B27/48 ,  G01J3/10 ,  G02B21/084

Abstract: The invention relates to imaging of an object's surface that is illuminated by scattered laser light. The goal of the invention is to ensure speckle-free digital images at illumination that is homogenized by means of reflective diffuser of laser beams. To reach the goal, a device comprising digital image sensor (2) having objective lens, laser irradiation unit (3), reflector (4) having a light scattering coating, mechanically vibrating element (6) and generator (7) of the vibrations is proposed. The reflector having a light scattering coating is fixed to the mechanically vibrating element; the vibration frequency f is selected to satisfy the condition f t>5, where t is an exposure time of the digital imaging. The moving part of an acoustic loudspeaker may be used as the mechanically vibrating element. The reflector having a light scattering coating may be ring-shaped, so that the image sensor with objective lens is located inside the reflecting-scattering ring.

公开(公告)号：WO2017025775A1

公开(公告)日：2017-02-16

申请号：PCT/IB2015/056097

申请日：2015-08-11

Applicant: LATVIJAS UNIVERSITATE

Inventor： RUBINS, Uldis ,  ZAHARANS, Janis ,  SPIGULIS, Janis

IPC: A61B5/0205 ,  A61B5/00 ,  A61B5/024 ,  A61B5/1455

CPC classification number: A61B5/0059 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/14551

Abstract: The present invention proposes a device for detection of hemodynamic parameter maps in a human skin by means of remote photoplethysmography imaging with adaptive illumination. The device comprises a video registration unit adapted for registering set of video frames of region of interest of subject's skin, said region having a number of sub-regions; a data processing unit adapted for processing obtained video signals and extracting photoplethysmography signals and set of hemodynamic parameters from each of the sub- regions; a display unit adapted to display hemodynamic parameter maps; an illuminator adapted to provide uniform illumination of the region of interest; a driver for regulating a power of illuminator; wherein the device further comprises a feedback unit adapted to receive from the data processing unit, the PPG signals from each of the sub-regions and to provide control of the illuminator to maintain uniform illumination of the region of interest; triggering unit for synchronous triggering of illuminator and video registration unit.

Abstract translation: 本发明提出了一种用于通过具有自适应照明的远程光体积描记术成像来检测人体皮肤中的血液动力学参数图的装置。 所述设备包括：视频注册单元，适于登记被摄体皮肤感兴趣区域的一组视频帧，所述区域具有多个子区域; 数据处理单元，适于处理所获得的视频信号并从每个子区域提取光电容积描记信号和一组血液动力学参数; 适于显示血液动力学参数图的显示单元; 适于提供感兴趣区域的均匀照明的照明器; 用于调节照明器功率的驱动器; 其中所述设备还包括反馈单元，其适于从所述数据处理单元接收来自每个子区域的PPG信号，并且提供所述照明器的控制以维持所述感兴趣区域的均匀照明; 触发单元，用于同步触发照明器和视频注册单元。

公开(公告)号：WO2015071786A1

公开(公告)日：2015-05-21

申请号：PCT/IB2014/065036

申请日：2014-10-03

Applicant: LATVIJAS UNIVERSITATE

Inventor： SPIGULIS, Janis

IPC: G01J3/28

CPC classification number: G01J3/2823 ,  G01J3/36 ,  G01J2003/2826

Abstract: The invention relates to spectral imaging, in particular to imaging of spectral reflectance distribution at several fixed wavelengths using a single RGB image data set. In the proposed method for obtaining several spectral reflectance images, they are extracted from a digital RGB image data set at the wavelengths corresponding to those used at polychromatic illumination of the target, providing linearity of the photo-response, using the reference reflector and taking into account the overlapping of the RGB photo-detector spectral sensitivity bands, where the spectral reflectance is calculated for each image pixel or group of pixels using a calibrated grey reference reflector with reflection coefficients at all exploited wavelengths less than those of the white reference and by value is close to the largest reflection coefficient of the displayed object area. In case of different intensities of the illumination spectral lines, corrections for spectral reflectance values are proposed.

Abstract translation: 本发明涉及光谱成像，特别涉及使用单个RGB图像数据集在几个固定波长处的光谱反射率分布的成像。 在所提出的用于获得几个光谱反射率图像的方法中，它们从与目标的多色照明下使用的波长相对应的波长的数字RGB图像数据集中提取，使用参考反射器提供光响应的线性，并且 考虑到RGB光检测器光谱灵敏度带的重叠，其中使用校准的灰色参考反射器对每个图像像素或像素组计算光谱反射率，所述校准灰色参考反射器在所有被利用的波长处的反射系数小于白色参考的值， 接近显示对象区域的最大反射系数。 在照明光谱线的强度不同的情况下，提出了光谱反射率值的校正。

公开(公告)号：WO2013135311A1

公开(公告)日：2013-09-19

申请号：PCT/EP2012/063889

申请日：2012-07-16

Applicant: LATVIJAS UNIVERSITATE ,  SPIGULIS, Janis ,  ELSTE, Liene

Inventor： SPIGULIS, Janis ,  ELSTE, Liene

IPC: G01J3/28 ,  G01J3/51 ,  G01J3/02 ,  H04N9/04

CPC classification number: G01J3/2823 ,  G01J3/021 ,  G01J3/28 ,  G01J3/51

Abstract: The invention relates to spectral imaging, in particular - to imaging of spectral reflectance distribution at a number of fixed wavelengths bands by means of a single RGB image data set. In the proposed method for obtaining a number of spectral reflectance images, the object and attached to it white reflector is illuminated simultaneously at a number of, for instance two or three, spectral bands, ensuring linearity of the photo-response, and the R;-, Gj- and Bj-signal values are identified for every image pixel "i", including those registered at the white reflector zone. If the spectral sensitivity curves of the image sensor R-, G- and B-channels are known, the spectral sensitivities at the illumination wavelengths are fixed. Their ratios are further used to determine the spectral imaging at every pixel or pixel group of the image for every wavelength of the poly-chromatic illumination, using the proposed analytic expressions for calculations. A device for imaging of spectral reflectance at a number of wavelength bands to implement this method comprises a poly-chromatic light source (1), objective-equipped digital RGB sensor (4), white reflector (3) that covers relatively small part of the surface to be imaged (2), RGB data set storage device (5), convertor (6) that converts the RGB data into a set of spectral reflectance values, imager (7) that produces the reflectance images related to each particular spectral band, and the output device (8), e.g. PC-monitor.

Abstract translation: 本发明涉及光谱成像，特别是涉及通过单个RGB图像数据集在多个固定波长带上的光谱反射率分布的成像。 在所提出的用于获得多个光谱反射率图像的方法中，物体并附着在其上的白色反射体被同时照射在多个例如两个或三个光谱带上，确保光响应的线性，并且R; - 对于每个图像像素“i”，识别出Gj和Bj信号值，包括在白色反射器区域上记录的那些。 如果图像传感器R-，G-和B-通道的光谱灵敏度曲线是已知的，则照明波长处的光谱灵敏度是固定的。 它们的比例进一步用于使用所提出的用于计算的分析表达式来确定多色照明的每个波长的图像的每个像素或像素组处的光谱成像。 用于对多个波长带的光谱反射率进行成像以实现该方法的装置包括多色光源（1），配备目标的数字RGB传感器（4），白色反射器（3），其覆盖相对较小的部分 要成像的表面（2），RGB数据集存储装置（5），将RGB数据转换成一组光谱反射率值的转换器（6），产生与每个特定光谱带相关的反射率图像的成像器（7） 和输出装置（8），例如 PC显示器。