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    SAMPLE STREAM CENTRATION
    1.
    发明申请
    SAMPLE STREAM CENTRATION 审中-公开

    公开(公告)号：WO2022232101A1

    公开(公告)日：2022-11-03

    申请号：PCT/US2022/026283

    申请日：2022-04-26

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： FINAN, Eric ,  WARD, Michael

    IPC: G01N15/14

    Abstract: Provided are, inter alia, flow centration components (100) that can be used in flow cytometers and other applications. A flow centrator can define central axis (116), a proximal end (106), and a distal end (108), and having a central bore (112) extending within the flow centration component in the direction of the central axis; the flow centration component defining a splined outer surface that defines a plurality of circumferentially arranged bypass flute channels (126), the plurality of bypass flute channels extending in the direction of the central axis, and each of the bypass flute channels having a depth and a length. Also provided are related methods that utilize the disclosed components.

    SYSTEMS, METHODS, AND APPARATUSES FOR OPTICAL SYSTEMS IN FLOW CYTOMETERS
    4.
    发明申请
    SYSTEMS, METHODS, AND APPARATUSES FOR OPTICAL SYSTEMS IN FLOW CYTOMETERS 审中-公开
    流式细胞仪中光学系统的系统，方法和装置

    公开(公告)号：WO2015130423A1

    公开(公告)日：2015-09-03

    申请号：PCT/US2015/013279

    申请日：2015-01-28

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： KADUCHAK, Gregory ,  SMITH, Wesley ,  WARD, Michael

    IPC: G01N15/14 ,  G01N21/17

    CPC classification number: G01N15/1459 ,  G01N15/1404 ,  G01N15/1434 ,  G01N15/1456 ,  G01N2015/1438

    Abstract: The present set of embodiments relate to a system, method, and apparatus for an optical configuration in a flow cytometer that allows for independent adjustment of focusing for each light source. Such systems, methods, and apparatuses require a final focusing element to be moved near the beginning of the optical train and for each optical element coming after the final focusing element to be configured to accommodate converging light beams while minimizing the introduction of aberrations into those beams.

    Abstract translation: 本组实施例涉及用于流式细胞仪中的光学配置的系统，方法和装置，其允许独立调整每个光源的聚焦。 这样的系统，方法和装置需要最终的聚焦元件在光学列车的开始附近移动，并且对于在最终聚焦元件之后的每个光学元件被配置成适应会聚的光束，同时最小化将像差引入到那些光束中 。

    SYSTEMS AND METHODS FOR DIAGNOSING A FLUIDICS SYSTEM AND DETERMINING DATA PROCESSING SETTINGS FOR A FLOW CYTOMETER
    7.
    发明申请
    SYSTEMS AND METHODS FOR DIAGNOSING A FLUIDICS SYSTEM AND DETERMINING DATA PROCESSING SETTINGS FOR A FLOW CYTOMETER 审中-公开
    用于诊断流体系统的系统和方法以及确定流量计的数据处理设置

    公开(公告)号：WO2015134139A1

    公开(公告)日：2015-09-11

    申请号：PCT/US2015/014210

    申请日：2015-02-03

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： KADUCHAK, Gregory ,  AKERLUND, Jace ,  MALKIN, Jason ,  WARD, Michael

    IPC: G01N15/14

    CPC classification number: G01N15/1012 ,  G01N15/1404 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1459 ,  G01N2015/1018 ,  G01N2015/1068 ,  G01N2015/1075 ,  G01N2015/1438

    Abstract: The present set of embodiments relates to systems and methods for diagnosing a fluidics system and determining data processing settings for a flow cytometer. Systems and methods for diagnosing a fluidics system require accurate measurement and interpretation of fluctuations within the fluid delivery system. Systems and methods for determining data processing settings require an accurate measurement of peak times among various channels and being able to adjust time delay settings wherein peak time is the measurement of time elapsed from the beginning of the data collection time window to the highest peak in the window.

    Abstract translation: 本组实施例涉及用于诊断流体系统并确定流式细胞仪的数据处理设置的系统和方法。 用于诊断流体系统的系统和方法需要准确测量和解释流体输送系统内的波动。 用于确定数据处理设置的系统和方法需要精确测量各种通道中的峰值时间，并且能够调整时间延迟设置，其中峰值时间是从数据采集时间窗口开始到数据采集时间窗口的最高峰值的时间的测量 窗口。

    METHODS, SYSTEMS AND DEVICES FOR CONCENTRATION OF PARTICLES
    8.
    发明申请
    METHODS, SYSTEMS AND DEVICES FOR CONCENTRATION OF PARTICLES 审中-公开
    用于粒子浓度的方法，系统和装置

    公开(公告)号：WO2018005984A1

    公开(公告)日：2018-01-04

    申请号：PCT/US2017/040322

    申请日：2017-06-30

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： WARD, Michael ,  SELBERG, Saul ,  MALKIN, Jason ,  LEFTON, Ken

    IPC: G01N15/14 ,  G01N15/10

    Abstract: The present disclosure provides devices, systems and methods for concentrating particles after application of a field and flipping the direction of the particles. The field applied to the particles can be an acoustic field. The particles can be flipped from a first flow stream at a higher speed into a second flow stream at a lower speed to aid in concentrating the particles, including concentration within an analysis region.

    Abstract translation: 本公开提供了用于在施加场并翻转粒子的方向之后浓缩粒子的装置，系统和方法。 应用于粒子的场可以是声场。 颗粒可以以较高的速度从第一流动物流翻转到较低速度的第二流动物流中以有助于浓缩颗粒，包括浓度在分析区域内。

    ACOUSTIC CYTOMETRY METHODS AND PROTOCOLS
    9.
    发明申请
    ACOUSTIC CYTOMETRY METHODS AND PROTOCOLS 审中-公开
    声学细胞测量方法和方法

    公开(公告)号：WO2013003498A2

    公开(公告)日：2013-01-03

    申请号：PCT/US2012/044463

    申请日：2012-06-27

    Applicant: LIFE TECHNOLOGIES CORPORATION ,  KADUCHAK, Gregory ,  WARD, Michael ,  BRADFORD, Jolene ,  DUBBELS, Bradley ,  SEREDICK, Barbara ,  KERNDT, Rickie ,  HAATAJA, Kristi ,  ANDERSON, April ,  MELQUIST, Penny ,  LANGSDORF, Christopher ,  HICKS, Justin ,  KIHN, Kathleen

    Inventor： KADUCHAK, Gregory ,  WARD, Michael ,  BRADFORD, Jolene ,  DUBBELS, Bradley ,  SEREDICK, Barbara ,  KERNDT, Rickie ,  HAATAJA, Kristi ,  ANDERSON, April ,  MELQUIST, Penny ,  LANGSDORF, Christopher ,  HICKS, Justin ,  KIHN, Kathleen

    IPC: G01N33/569 ,  G01N15/00

    CPC classification number: G01N33/56966 ,  G01N15/1404 ,  G01N21/6408 ,  G01N21/6486 ,  G01N2015/142

    Abstract: Various embodiments disclosed herein comprise acoustic cytometry based methods, kits, computer software methods and systems to analyze a variety of bioparticles. In one embodiment, a method for analyzing bioparticles comprises: acoustically focusing one or more bioparticles through an interrogation zone; optically exciting the one or more bioparticles in the interrogation zone with an excitation source; detecting an optical signal from the bioparticles; and analyzing the optical signal to characterize at least one quality or quantity parameter of the bioparticles. Properties of biomolecules that may be analyzed include but are not limited to cell proliferation analysis, live/dead cell discrimination, cell cycle analysis, basic phenotyping, immunophenotyping, rare-event detection, apoptosis, phagocytosis, pinocytosis, detection of phosphoproteins, detection of one or more cellular markers, detection of one or more intracellular marker, detection of cancer cells, detection of pathological markers on a cell, microbial cell analysis and/or picophytoplankton analysis.

    Abstract translation: 本文公开的各种实施方案包括基于声学细胞计数的方法，试剂盒，计算机软件方法和系统以分析各种生物颗粒。 在一个实施例中，用于分析生物颗粒的方法包括：通过询问区声学地聚焦一个或多个生物颗粒; 用激发源在询问区中光学激发所述一个或多个生物颗粒; 检测来自生物颗粒的光学信号; 以及分析光信号以表征生物颗粒的至少一个质量或数量参数。 可以分析的生物分子的性质包括但不限于细胞增殖分析，活/死细胞鉴别，细胞周期分析，基本表型分型，免疫表型分析，稀有事件检测，细胞凋亡，吞噬作用，胞饮作用，磷酸化蛋白检测， 或更多的细胞标记物，检测一种或多种细胞内标记物，检测癌细胞，检测细胞上的病理标记物，微生物细胞分析和/或微微型浮游生物分析。

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